Published in Nat Rev Immunol on February 01, 2004
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res (2009) 3.29
The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol (2012) 3.20
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15
Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res (2011) 2.94
Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol (2005) 2.94
Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol (2009) 2.68
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol (2010) 2.66
Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med (2004) 2.47
T cell subset-specific susceptibility to aging. Clin Immunol (2008) 2.42
Heterologous immunity between viruses. Immunol Rev (2010) 2.20
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med (2012) 2.19
Immunological complications of obesity. Nat Immunol (2012) 2.09
Aging and T-cell diversity. Exp Gerontol (2007) 2.06
Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med (2013) 1.86
Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med (2005) 1.85
Ghrelin promotes thymopoiesis during aging. J Clin Invest (2007) 1.83
Evidence of premature immune aging in patients thymectomized during early childhood. J Clin Invest (2009) 1.81
IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nat Commun (2013) 1.71
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 1.64
Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A (2014) 1.63
Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells. Blood (2009) 1.62
Diversity-generating retroelements. Curr Opin Microbiol (2007) 1.58
T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol (2009) 1.55
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci Transl Med (2012) 1.53
Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J Immunol (2009) 1.53
Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proc Natl Acad Sci U S A (2011) 1.51
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response. J Exp Med (2009) 1.47
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proc Natl Acad Sci U S A (2016) 1.41
Concern Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy. Front Immunol (2013) 1.41
Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clin Exp Immunol (2015) 1.40
Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol (2014) 1.31
Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCR. Curr Protoc Immunol (2011) 1.30
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol (2009) 1.28
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A (2008) 1.24
Does intra-individual major histocompatibility complex diversity keep a golden mean? Philos Trans R Soc Lond B Biol Sci (2009) 1.20
Sequence analysis of T-cell repertoires in health and disease. Genome Med (2013) 1.17
The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep (2012) 1.14
Age-related changes in CD8 T cell homeostasis and immunity to infection. Semin Immunol (2012) 1.14
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility. Sci Transl Med (2015) 1.12
Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire. J Immunol (2011) 1.09
Determinants of public T cell responses. Cell Res (2012) 1.09
Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life. J Immunol (2012) 1.08
The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor. Front Immunol (2013) 1.07
Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells. Haematologica (2011) 1.04
The narrowing of the CD8 T cell repertoire in old age. Curr Opin Immunol (2011) 1.04
Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens. Cancer Immunol Immunother (2006) 1.04
Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response. J Allergy Clin Immunol (2015) 1.03
T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology (2012) 1.03
Tolerance, suppression and the fetal allograft. J Mol Med (Berl) (2004) 1.02
Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses. Am J Transplant (2008) 1.00
The role of nutrition in enhancing immunity in aging. Aging Dis (2011) 0.99
Concurrent vaccination with two distinct vaccine platforms targeting the same antigen generates phenotypically and functionally distinct T-cell populations. Cancer Immunol Immunother (2009) 0.98
Heat shock proteins, autoimmunity, and cancer treatment. Autoimmune Dis (2012) 0.98
Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation. J Immunol (2011) 0.98
Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells. Immunol Cell Biol (2016) 0.97
Analysis of T cell receptor Vbeta diversity in peripheral CD4 and CD8 T lymphocytes in patients with autoimmune thyroid diseases. Clin Exp Immunol (2008) 0.96
Peptide-MHC class II complex stability governs CD4 T cell clonal selection. J Immunol (2009) 0.96
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol (2013) 0.95
Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues. Proc Natl Acad Sci U S A (2008) 0.94
Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome. Front Immunol (2014) 0.92
Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo. Blood (2010) 0.92
Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity (2014) 0.92
Thymic involution, a co-morbidity factor in amyotrophic lateral sclerosis. J Cell Mol Med (2010) 0.91
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Crit Rev Immunol (2013) 0.91
Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach. Philos Trans R Soc Lond B Biol Sci (2015) 0.91
Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation (2009) 0.91
Genomic analysis reveals extensive gene duplication within the bovine TRB locus. BMC Genomics (2009) 0.90
A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement. J Immunol (2009) 0.90
Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res (2008) 0.89
Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog (2013) 0.89
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance. Front Immunol (2012) 0.89
Quorum sensing allows T cells to discriminate between self and nonself. Proc Natl Acad Sci U S A (2013) 0.89
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88
Quantification of total T-cell receptor diversity by flow cytometry and spectratyping. BMC Immunol (2013) 0.88
Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies. J Immunol (2008) 0.87
Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes. Immunol Cell Biol (2009) 0.87
Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution. Aging Cell (2010) 0.87
Control of T cell antigen reactivity via programmed TCR downregulation. Nat Immunol (2016) 0.87
T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease. Biol Blood Marrow Transplant (2006) 0.86
Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection. Nat Commun (2012) 0.86
The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4(+)CD25(+) regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment. Cell Mol Immunol (2016) 0.86
Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Am J Transplant (2013) 0.85
Clonal restriction and predominance of regulatory T cells in coronary thrombi of patients with acute coronary syndromes. Eur Heart J (2014) 0.85
[Human leukocyte antigen (HLA) system in ophthalmology]. Ophthalmologe (2013) 0.85
Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins. Mol Cell Proteomics (2013) 0.84
Current status and recent advances of next generation sequencing techniques in immunological repertoire. Genes Immun (2016) 0.84
The contribution of the thymus to the recovery of peripheral naive T-cell numbers during antiretroviral treatment for HIV infection. J Acquir Immune Defic Syndr (2008) 0.84
Clinical transplantation tolerance. Semin Immunopathol (2011) 0.83
A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging. Immunology (2014) 0.83
Immune Tolerance for Autoimmune Disease and Cell Transplantation. Annu Rev Biomed Eng (2016) 0.83
The race for the prize: T-cell trafficking strategies for optimal surveillance. Blood (2012) 0.82
Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool. PLoS One (2013) 0.82
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation. Oncoimmunology (2013) 0.82
Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor. Cancer Immunol Res (2016) 0.81
Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion. J Immunol (2015) 0.81
Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J Immunol (2015) 0.81
Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains. Protein Cell (2014) 0.81
Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors. Sci Rep (2015) 0.81
Duration of antiviral immunity after smallpox vaccination. Nat Med (2003) 7.39
Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med (2007) 6.13
Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med (2005) 2.57
Immunity and immunological memory following smallpox vaccination. Immunol Rev (2006) 2.57
Mechanisms that determine plasma cell lifespan and the duration of humoral immunity. Immunol Rev (2010) 1.99
Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J Virol (2002) 1.92
Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates. Proc Natl Acad Sci U S A (2013) 1.81
Protective immunity following vaccination: how is it defined? Hum Vaccin (2008) 1.70
How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis (2004) 1.60
Contributions of humoral and cellular immunity to vaccine-induced protection in humans. Virology (2011) 1.53
Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci U S A (2007) 1.53
Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition. Cell Host Microbe (2009) 1.47
Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol (2005) 1.43
Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon. J Virol (2002) 1.42
Quantitation of rare memory B cell populations by two independent and complementary approaches. J Immunol Methods (2006) 1.41
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A (2012) 1.38
Cytokine-mediated programmed proliferation of virus-specific CD8(+) memory T cells. Immunity (2012) 1.31
Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18. J Immunol (2004) 1.30
Development of a new hydrogen peroxide–based vaccine platform. Nat Med (2012) 1.24
A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS Negl Trop Dis (2011) 1.23
Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J Immunol (2004) 1.20
Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood (2003) 1.20
The rapidity with which virus-specific CD8+ T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. J Immunol (2004) 1.12
Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27. Arch Immunol Ther Exp (Warsz) (2006) 1.11
Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I molecules. J Immunol (2007) 1.09
Simian varicella virus pathogenesis. Curr Top Microbiol Immunol (2010) 1.08
The role of mhc polymorphism in anti-microbial resistance. Microbes Infect (2004) 1.07
Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood (2004) 1.04
Simian varicella virus gene expression during acute and latent infection of rhesus macaques. J Neurovirol (2011) 1.03
Simian herpesviruses and their risk to humans. Vaccine (2010) 1.02
Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus. J Virol (2012) 1.02
Wanted, dead or alive: new viral vaccines. Antiviral Res (2009) 1.02
Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. J Allergy Clin Immunol (2011) 1.01
Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques. J Virol (2013) 0.99
A hydrogen peroxide-inactivated virus vaccine elicits humoral and cellular immunity and protects against lethal West Nile virus infection in aged mice. J Virol (2012) 0.98
CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection. PLoS Pathog (2011) 0.98
Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol (2011) 0.98
Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication. J Immunol (2008) 0.97
Immune senescence in aged nonhuman primates. Exp Gerontol (2010) 0.96
Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta). Pathobiol Aging Age Relat Dis (2012) 0.95
Chronic ethanol consumption modulates growth factor release, mucosal cytokine production, and microRNA expression in nonhuman primates. Alcohol Clin Exp Res (2013) 0.95
A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. Alcohol Clin Exp Res (2011) 0.95
Public fear of vaccination: separating fact from fiction. Viral Immunol (2005) 0.95
Current trends in West Nile virus vaccine development. Expert Rev Vaccines (2014) 0.93
Quantifying viable virus-specific T cells without a priori knowledge of fine epitope specificity. Nat Med (2006) 0.92
Pivotal advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection. J Leukoc Biol (2007) 0.92
Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase. J Virol (2005) 0.91
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells. PLoS Pathog (2006) 0.91
GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination. PLoS One (2011) 0.90
Antiviral immunity following smallpox virus infection: a case-control study. J Virol (2010) 0.90
A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory. J Immunol (2013) 0.89
Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation. Proc Natl Acad Sci U S A (2008) 0.89
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques. Mol Metab (2013) 0.88
Cytomegalovirus CC chemokine promotes immune cell migration. J Virol (2012) 0.87
Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques. J Virol (2010) 0.87
Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques. Age (Dordr) (2010) 0.87
Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection. J Virol (2011) 0.87
The regulation and maturation of antiviral immune responses. Adv Virus Res (2004) 0.86
Retrospective analysis of monkeypox infection. Emerg Infect Dis (2008) 0.86
Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection. J Virol (2011) 0.85
The capacity of UL49.5 proteins to inhibit TAP is widely distributed among members of the genus Varicellovirus. J Virol (2010) 0.85
Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection. J Virol (2011) 0.84
Longevity of T-cell memory following acute viral infection. Adv Exp Med Biol (2010) 0.84
Monkeypox without exanthem. N Engl J Med (2007) 0.84
Serologic evidence for novel poxvirus in endangered red Colobus monkeys, Western Uganda. Emerg Infect Dis (2008) 0.84
Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment. Vaccine (2007) 0.83
Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution. J Exp Med (2004) 0.83
Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine. J Virol (2012) 0.83
Attenuation of the adaptive immune response in rhesus macaques infected with simian varicella virus lacking open reading frame 61. J Virol (2012) 0.82
T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response. JCI Insight (2017) 0.82
CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation. Virology (2009) 0.81
Cutaneous responses to vaccinia in individuals with previous smallpox vaccination. J Am Acad Dermatol (2007) 0.81
Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells. Virology (2009) 0.81
Overview of aging research using nonhuman primate models. Age (Dordr) (2012) 0.81
Impact of infection or vaccination on pre-existing serological memory. Hum Immunol (2012) 0.80
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells. PLoS One (2012) 0.80
Spatial Memory Performance Associated with Measures of Immune Function in Elderly Female Rhesus Macaques. Eur Geriatr Med (2011) 0.80
Autophagic Killing Effects against Mycobacterium tuberculosis by Alveolar Macrophages from Young and Aged Rhesus Macaques. PLoS One (2013) 0.79
Optimization of peptide-based ELISA for serological diagnostics: a retrospective study of human monkeypox infection. Vector Borne Zoonotic Dis (2012) 0.78
Measures of anxiety, amygdala volumes, and hippocampal scopolamine phMRI response in elderly female rhesus macaques. Neuropharmacology (2011) 0.78
Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivo. Virol J (2013) 0.78
Age and immune status of rhesus macaques impact simian varicella virus gene expression in sensory ganglia. J Virol (2013) 0.78
Genome-wide analysis of T cell responses during acute and latent simian varicella virus infections in rhesus macaques. J Virol (2013) 0.77
A flow cytometry-based assay for quantifying non-plaque forming strains of yellow fever virus. PLoS One (2012) 0.77
The immunostimulatory power of acute viral infection. Immunity (2008) 0.76
Antibody-mediated protection against respiratory viral infection. Semin Respir Crit Care Med (2005) 0.76
Improving immunity in the elderly: current and future lessons from nonhuman primate models. Age (Dordr) (2011) 0.76
Antiviral immune response after live yellow fever vaccination of a kidney transplant recipient treated with IVIG. Transplantation (2013) 0.75
Editorial: Profiling senescent influenza-specific T cells in the elderly. J Leukoc Biol (2013) 0.75
CTLA4, T cell function, and long term immunity: an interview with Dr. Mark K. Slifka. Interview by Helene F. Rosenberg. J Leukoc Biol (2007) 0.75
Keystone conference on viral immunity: from basic mechanisms to vaccines (X7) and advances in influenza research: from birds to bench to bedside (X8) Steamboat Springs, Colorado March 28-April 2, 2006. Viral Immunol (2006) 0.75