Published in Toxicol Appl Pharmacol on May 01, 2004
Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior. Arch Biochem Biophys (2009) 1.41
Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry (2007) 1.20
Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings. Acta Naturae (2009) 0.84
Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase. Front Chem (2014) 0.79
Recombinant human butyrylcholinesterase as a new-age bioscavenger drug: development of the expression system. Acta Naturae (2013) 0.78
Purification and studies on characteristics of cholinesterases from Daphnia magna. J Zhejiang Univ Sci B (2013) 0.78
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol (2005) 4.79
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. J Biol Chem (2003) 2.88
Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (2004) 2.54
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet (2003) 2.36
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature (2003) 2.22
Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol Pharmacol (2002) 2.21
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem Pharmacol (2005) 2.05
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J Pharmacol Exp Ther (2002) 1.91
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J (2012) 1.71
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome (2007) 1.68
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell (2010) 1.57
Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Dev Dyn (2006) 1.54
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51
Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity. J Pharmacol Exp Ther (2002) 1.48
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes. Transgenic Res (2009) 1.43
Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior. Arch Biochem Biophys (2009) 1.41
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem (2009) 1.37
Advances in transgenic rat production. Transgenic Res (2006) 1.36
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci (2004) 1.35
Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization. Eur J Biochem (2002) 1.35
A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J Biol Chem (2006) 1.29
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal Biochem (2006) 1.29
Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging. Biochemistry (2005) 1.29
Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol (2006) 1.27
Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet (2004) 1.26
LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY. J Med Chem Biol Radiol Def (2005) 1.24
Binding and hydrolysis of soman by human serum albumin. Chem Res Toxicol (2007) 1.18
Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem (2008) 1.17
Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology (2008) 1.17
Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J (2008) 1.16
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci U S A (2009) 1.16
Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse. Brain Res Dev Brain Res (2002) 1.15
SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell (2011) 1.13
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest (2011) 1.10
The butyrylcholinesterase knockout mouse is obese on a high-fat diet. Chem Biol Interact (2008) 1.09
Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition. J Clin Invest (2011) 1.07
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol (2008) 1.06
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol (2009) 1.06
Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. J Neurochem (2006) 1.06
Development of diagnostics in the search for an explanation of aerotoxic syndrome. Anal Biochem (2010) 1.04
Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem (2008) 1.04
Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol Cell Biol (2003) 1.03
Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci (2007) 1.03
Exposure to tri-o-cresyl phosphate detected in jet airplane passengers. Toxicol Appl Pharmacol (2011) 1.03
Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis (2007) 1.03
Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents. Chem Biol Interact (2008) 1.02
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters. Chem Biol Interact (2008) 1.02
Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410). Anal Biochem (2005) 1.01
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation. J Am Chem Soc (2008) 1.01
A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Res (2007) 1.00
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension. Proc Natl Acad Sci U S A (2012) 1.00
Biomarkers of organophosphorus (OP) exposures in humans. Neurotoxicology (2011) 0.99
Rederivation of transgenic and gene-targeted mice by embryo transfer. Transgenic Res (2004) 0.98
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Mol Pharmacol (2003) 0.97
Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose. J Appl Toxicol (2010) 0.95
A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India. Clin Chim Acta (2006) 0.94
Mass spectrometry identifies multiple organophosphorylated sites on tubulin. Toxicol Appl Pharmacol (2009) 0.94
Production of the butyrylcholinesterase knockout mouse. J Mol Neurosci (2006) 0.93
Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chem Res Toxicol (2011) 0.93
Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. FEBS J (2012) 0.92
Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.92
The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency. J Pharmacol Exp Ther (2007) 0.92
Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact (2009) 0.92
Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos. Toxicol Sci (2010) 0.92
Structural approach to the aging of phosphylated cholinesterases. Chem Biol Interact (2010) 0.92
Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol (2009) 0.92
Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis. Chem Res Toxicol (2011) 0.91
Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity. Toxicol Appl Pharmacol (2009) 0.91
Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. Toxicol Sci (2008) 0.91
Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci (2010) 0.91
Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system. Chem Biol Interact (2010) 0.91
Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol (2005) 0.90
Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain. Neurotoxicology (2009) 0.89
Beta-mannosidosis mice: a model for the human lysosomal storage disease. Hum Mol Genet (2005) 0.89
Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice. Muscle Nerve (2004) 0.89
Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545. Biochem Pharmacol (2009) 0.89
X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger. Biochem J (2011) 0.89