PubRank

C J Rhodes

Author PubWeight™ 86.23‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006 10.64
2 Measles outbreaks in a population with declining vaccine uptake. Science 2003 4.47
3 Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001 3.70
4 Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation 2000 2.18
5 Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature 1988 2.07
6 The Lévy flight paradigm: random search patterns and mechanisms. Ecology 2009 2.05
7 Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol 2011 1.96
8 Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes 2001 1.77
9 Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 1999 1.72
10 Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 1998 1.64
11 Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 2004 1.59
12 Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Endocrinology 2001 1.55
13 Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. Proc Natl Acad Sci U S A 1996 1.52
14 Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 2005 1.44
15 Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway. J Cell Biol 1987 1.43
16 Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 1998 1.39
17 The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 1993 1.36
18 Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J 1989 1.32
19 Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 2001 1.28
20 Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia 2010 1.25
21 Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J Biol Chem 2001 1.24
22 PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science 1996 1.22
23 Radiological Investigation of the Small Intestine by Small Bowel Enema Technique. Gut 1960 1.21
24 Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am J Physiol Endocrinol Metab 2000 1.16
25 Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem 2000 1.16
26 The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead? Diabetes Obes Metab 2007 1.15
27 Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes 2000 1.13
28 Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest 1995 1.11
29 Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia 2006 1.09
30 Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes 2001 1.08
31 The effect of superspreading on epidemic outbreak size distributions. J Theor Biol 2008 1.07
32 Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proc Natl Acad Sci U S A 1999 1.07
33 Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J 1998 1.06
34 Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J 1999 1.02
35 PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 1993 1.01
36 Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem 1987 1.00
37 Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin. J Biol Chem 1989 0.96
38 Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet. J Biol Chem 1994 0.96
39 A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes 1998 0.96
40 Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). J Mol Endocrinol 2003 0.95
41 A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem J 1996 0.95
42 Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes 1996 0.93
43 Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes 2000 0.91
44 High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia 1986 0.91
45 Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.). Free Radic Res 1997 0.91
46 Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules. Biochem Biophys Res Commun 1992 0.88
47 Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochem J 1996 0.88
48 Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A 1996 0.85
49 A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis. Diabetes 2001 0.84
50 A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 1998 0.82
51 Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet? Diabetologia 2005 0.82
52 Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets. FEBS Lett 1987 0.82
53 Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus. Diabetologia 1984 0.82
54 Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism. Diabetes 2001 0.82
55 An evaluation of the use of Sep-Pak C18 cartridges for the extraction of vitamin D3 and some of its metabolites from plasma and urine. J Steroid Biochem 1983 0.81
56 Biosynthesis and storage of insulin. Biochem Soc Trans 1990 0.81
57 Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells. FEBS Lett 1998 0.81
58 Degradation of islet amyloid polypeptide by neprilysin. Diabetologia 2012 0.81
59 A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor. Biochem J 1994 0.80
60 Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. Biochem J 1989 0.80
61 Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol 2005 0.80
62 Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans. Biochem J 1985 0.78
63 Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function. Clin Sci (Lond) 1985 0.78
64 2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets. FEBS Lett 1985 0.77
65 Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets. Diabetologia 1984 0.75
66 How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats. Diabetologia 1998 0.75
67 Medico-legal issues in occupational lung disease litigation. Semin Roentgenol 1992 0.75
68 [Biogenesis of the insulin secretion granule]. Journ Annu Diabetol Hotel Dieu 1989 0.75
69 The enzymology of proinsulin conversion. Cell Biophys 1993 0.75