Published in J Cell Biol on April 19, 2004
Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol (2005) 5.82
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A (2008) 3.29
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
Replication licensing and cancer--a fatal entanglement? Nat Rev Cancer (2008) 2.86
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Mol Biol Cell (2007) 1.65
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell Div (2006) 1.38
Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Nat Struct Mol Biol (2009) 1.36
Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem (2007) 1.36
Cdk2 is required for p53-independent G2/M checkpoint control. PLoS Genet (2010) 1.21
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. PLoS Genet (2010) 1.20
Cdc45 limits replicon usage from a low density of preRCs in mammalian cells. PLoS One (2011) 1.19
The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep (2006) 1.16
Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res (2005) 1.16
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion. EMBO J (2009) 1.15
Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells. PLoS One (2007) 1.13
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication. BMC Mol Biol (2004) 1.06
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Nucleic Acids Res (2013) 1.03
Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts. Nucleic Acids Res (2005) 1.03
Differential binding of replication proteins across the human c-myc replicator. Mol Cell Biol (2006) 1.02
The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair (Amst) (2014) 1.01
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle. Exp Cell Res (2005) 0.95
DNA is a co-factor for its own replication in Xenopus egg extracts. Nucleic Acids Res (2010) 0.95
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase. PLoS One (2009) 0.92
Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods (2012) 0.92
TIF1 Represses rDNA replication initiation, but promotes normal S phase progression and chromosome transmission in Tetrahymena. Mol Biol Cell (2005) 0.91
Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Mol Cell Proteomics (2015) 0.90
Replication licensing and the DNA damage checkpoint. Front Biosci (Landmark Ed) (2009) 0.90
Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest. J Biol Chem (2009) 0.87
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Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival. Mol Biol Cell (2009) 0.84
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation. Cell Cycle (2013) 0.83
The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. PLoS One (2008) 0.82
Optimal placement of origins for DNA replication. Phys Rev Lett (2012) 0.81
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. Biochim Biophys Acta (2011) 0.81
Decreased MCM2-6 in Drosophila S2 cells does not generate significant DNA damage or cause a marked increase in sensitivity to replication interference. PLoS One (2011) 0.81
Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling. Cell Rep (2017) 0.81
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. Nucleic Acids Res (2010) 0.79
Emerging players in the initiation of eukaryotic DNA replication. Cell Div (2012) 0.78
Significant role of Psf3 expression in non-small-cell lung cancer. Cancer Sci (2015) 0.77
Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus (2011) 0.77
Behavior of replication origins in Eukaryota - spatio-temporal dynamics of licensing and firing. Cell Cycle (2015) 0.76
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines. Cell Chem Biol (2017) 0.75
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol (2000) 9.21
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem (1997) 6.99
Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell (1998) 6.69
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science (2000) 6.48
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature (1998) 6.47
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A (1997) 5.51
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol (2001) 5.37
The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell (1996) 4.80
Regulation of DNA-replication origins during cell-cycle progression. Nature (1998) 4.52
The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol (2003) 4.27
Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (1995) 4.00
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev (2000) 3.96
Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell (1996) 3.45
The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J (1997) 3.35
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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J Cell Biol (1998) 3.13
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MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem (2002) 3.00
Replication licensing--defining the proliferative state? Trends Cell Biol (2002) 2.91
Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. J Cell Biol (1997) 2.58
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev (2000) 2.58
Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem. Bioessays (2003) 2.54
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol (1998) 2.54
Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J Cell Biol (1998) 2.51
Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. J Cell Sci (1999) 2.51
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem (2001) 2.36
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev (1997) 2.34
Control of DNA replication licensing in a cell cycle. Genes Cells (2002) 2.34
Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr Opin Genet Dev (2001) 2.28
The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. EMBO J (1997) 2.27
Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev (1997) 2.16
Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. Genes Dev (2000) 2.10
Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol Biol Cell (1999) 2.07
Replication origins in Xenopus egg extract Are 5-15 kilobases apart and are activated in clusters that fire at different times. J Cell Biol (2001) 2.07
The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr Biol (2000) 1.98
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Characterization of the Xenopus replication licensing system. Methods Enzymol (1997) 1.88
Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J Biol Chem (2000) 1.84
Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J Cell Biol (2001) 1.66
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev (2000) 1.66
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol (2002) 1.63
Control of chromosomal DNA replication in the early Xenopus embryo. EMBO J (2001) 1.57
Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process. J Cell Sci (2000) 1.53
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat Cell Biol (2004) 1.45
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. Curr Biol (1999) 1.41
Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci U S A (1997) 1.34
Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle. Genes Dev (2000) 1.32
Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. Mol Cell Biol (2004) 1.31
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J (2003) 1.28
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Cdc18 transcription and proteolysis couple S phase to passage through mitosis. EMBO J (1998) 1.27
Triggering ubiquitination of a CDK inhibitor at origins of DNA replication. Nat Cell Biol (2001) 1.17
Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication. Nucleic Acids Res (2000) 1.15
Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin. EMBO J (2002) 1.14
Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases. Nature (2001) 1.04
Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nat Cell Biol (2002) 1.00
Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication. Genes Dev (2002) 0.99
Xenopus Cdc6 performs separate functions in initiating DNA replication. Mol Biol Cell (2002) 0.96
The origin of CDK regulation. Nat Cell Biol (2001) 0.88
Evidence that DNA replication is not regulated by ubiquitin-dependent proteolysis in Xenopus egg extract. Exp Cell Res (2003) 0.83
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell (2006) 3.56
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
Regulating the licensing of DNA replication origins in metazoa. Curr Opin Cell Biol (2006) 2.08
Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene (2002) 1.91
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol Cell (2006) 1.73
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. J Cell Sci (2004) 1.72
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol (2002) 1.63
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol (2010) 1.63
ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing. Curr Biol (2007) 1.61
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci (2002) 1.51
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat Cell Biol (2004) 1.45
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell (2011) 1.24
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription. Nucleic Acids Res (2005) 1.22
Bod1, a novel kinetochore protein required for chromosome biorientation. J Cell Biol (2007) 1.22
DNA replication licensing in somatic and germ cells. J Cell Sci (2004) 1.21
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol (2010) 1.20
Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res (2005) 1.16
Clusters, factories and domains: The complex structure of S-phase comes into focus. Cell Cycle (2010) 1.15
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell (2013) 1.14
PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev Cell (2013) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication. BMC Mol Biol (2004) 1.06
Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. Curr Biol (2008) 1.04
Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res (2008) 1.03
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J Cell Sci (2012) 1.02
The elusive determinants of replication origins. EMBO Rep (2007) 1.01
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes Dev (2013) 1.00
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res (2013) 0.99
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst) (2008) 0.95
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods (2012) 0.92
The licensing checkpoint opens up. Cell Cycle (2009) 0.86
Stochastic association of neighboring replicons creates replication factories in budding yeast. J Cell Biol (2013) 0.85
Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach. Proteome Sci (2004) 0.85
Histone acetylation by HBO1 tightens replication licensing. Mol Cell (2010) 0.85
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation. Cell Cycle (2013) 0.83
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. Biochim Biophys Acta (2011) 0.81
Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing. Cell Cycle (2004) 0.81
The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. J Biol Chem (2013) 0.81
Optimal placement of origins for DNA replication. Phys Rev Lett (2012) 0.81
The role of the replication licensing system in cell proliferation and cancer. Prog Cell Cycle Res (2003) 0.81
A role for dormant origins in tumor suppression. Mol Cell (2011) 0.79
Cell Cycle Synchronization in Xenopus Egg Extracts. Methods Mol Biol (2016) 0.77
Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus (2011) 0.77
Degradation ensures integrity. Nature (2003) 0.76
Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun (2015) 0.75