Published in Curr Opin Struct Biol on February 01, 2004
Base-excision repair of oxidative DNA damage. Nature (2007) 5.44
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc Natl Acad Sci U S A (2010) 1.61
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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature (2010) 1.36
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An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene. Proc Natl Acad Sci U S A (2004) 1.18
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae. Genetics (2013) 1.17
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Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats. Nucleic Acids Res (2007) 1.06
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc Natl Acad Sci U S A (2012) 1.05
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A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD. J Mol Biol (2008) 0.99
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Formation and repair of tobacco carcinogen-derived bulky DNA adducts. J Nucleic Acids (2010) 0.98
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Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucleic Acids Res (2008) 0.95
DNA glycosylases search for and remove oxidized DNA bases. Environ Mol Mutagen (2013) 0.94
Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA. J Mol Biol (2012) 0.93
Duplex interrogation by a direct DNA repair protein in search of base damage. Nat Struct Mol Biol (2012) 0.91
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Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg. Biochemistry (2007) 0.90
Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer. Antioxid Redox Signal (2012) 0.89
An HPLC-tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products. Methods (2013) 0.89
Base flipping in tn10 transposition: an active flip and capture mechanism. PLoS One (2009) 0.88
Analysis of an anomalous mutant of MutM DNA glycosylase leads to new insights into the catalytic mechanism. J Am Chem Soc (2009) 0.88
Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases. DNA Repair (Amst) (2013) 0.86
Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity. PLoS One (2010) 0.86
A rapid reaction analysis of uracil DNA glycosylase indicates an active mechanism of base flipping. Nucleic Acids Res (2007) 0.86
Insights into the glycosylase search for damage from single-molecule fluorescence microscopy. DNA Repair (Amst) (2014) 0.85
Base excision repair capacity in informing healthspan. Carcinogenesis (2014) 0.84
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. PLoS One (2011) 0.84
Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. DNA Repair (Amst) (2012) 0.84
Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1. J Am Chem Soc (2008) 0.83
Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases. Nucleic Acids Res (2004) 0.83
Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. Proc Natl Acad Sci U S A (2010) 0.83
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice. Chem Res Toxicol (2012) 0.83
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry (2015) 0.83
DNA damage and repair in plants under ultraviolet and ionizing radiations. ScientificWorldJournal (2015) 0.82
DNA methylation and demethylation in Arabidopsis. Arabidopsis Book (2008) 0.82
Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines. J Nucleic Acids (2010) 0.82
Energetic coupling between clustered lesions modulated by intervening triplet repeat bulge loops: allosteric implications for DNA repair and triplet repeat expansion. Biopolymers (2010) 0.81
Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages. J Biol Chem (2014) 0.80
Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway. PLoS One (2012) 0.78
Hidden Conformation Events in DNA Base Extrusions: A Generalized Ensemble Path Optimization and Equilibrium Simulation Study. J Chem Theory Comput (2013) 0.78
Location of DNA damage by charge exchanging repair enzymes: effects of cooperativity on location time. Theor Biol Med Model (2005) 0.77
Templated chemistry for monitoring damage and repair directly in duplex DNA. Chem Commun (Camb) (2012) 0.77
In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity. Nucleic Acids Res (2014) 0.76
Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair. Proc Natl Acad Sci U S A (2016) 0.75
Apurinic/apyrimidinic endonucleases of Mycobacterium tuberculosis protect against DNA damage but are dispensable for the growth of the pathogen in guinea pigs. PLoS One (2014) 0.75
Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase. PLoS One (2016) 0.75
Novel mutations of OGG1 base excision repair pathway gene in laryngeal cancer patients. Fam Cancer (2012) 0.75
Phaeocystis globosa Virus DNA Polymerase X: a "Swiss Army knife", Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair. Sci Rep (2017) 0.75
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
A stapled BID BH3 helix directly binds and activates BAX. Mol Cell (2006) 3.86
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67
Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med (2013) 3.65
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature (2004) 3.30
Structure of a DNA glycosylase searching for lesions. Science (2006) 2.72
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc (2007) 2.71
Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? J Trauma (2008) 2.52
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol (2009) 2.12
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nat Immunol (2007) 2.08
Effect of blood products transfusion on the development of postinjury multiple organ failure. Arch Surg (2010) 2.04
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc Natl Acad Sci U S A (2012) 1.98
Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J Leukoc Biol (2005) 1.94
Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann Thorac Surg (2008) 1.91
DNA lesion recognition by the bacterial repair enzyme MutM. J Biol Chem (2003) 1.79
Structure of a trapped endonuclease III-DNA covalent intermediate. EMBO J (2003) 1.72
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM. Nat Struct Biol (2002) 1.67
Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature (2009) 1.67
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Nat Struct Mol Biol (2006) 1.66
Base excision repair. Adv Protein Chem (2004) 1.65
HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock (2009) 1.64
Validation of postinjury multiple organ failure scores. Shock (2009) 1.64
Direct visualization of a DNA glycosylase searching for damage. Chem Biol (2002) 1.53
Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med (2012) 1.51
Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography. Ann Surg (2010) 1.51
Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg (2013) 1.49
Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell (2003) 1.49
The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med (2009) 1.48
Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol (2004) 1.48
Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase. J Surg Res (2011) 1.44
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis. Nat Protoc (2011) 1.44
Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha. J Biol Chem (2006) 1.43
Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg (2014) 1.43
A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias. J Biol Chem (2005) 1.41
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase. Biochemistry (2003) 1.40
Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure. Surgery (2006) 1.39
Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol (2003) 1.34
Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem (2005) 1.32
Structure of the stapled p53 peptide bound to Mdm2. J Am Chem Soc (2011) 1.30
Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock (2002) 1.29
Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2008) 1.24
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. J Biol Chem (2005) 1.24
Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J Biol Chem (2006) 1.24
A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex. Proc Natl Acad Sci U S A (2006) 1.23
Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. Mol Cell (2007) 1.21
Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph. Surgery (2009) 1.20
Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol (2006) 1.18
Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration. Mol Microbiol (2010) 1.18
High-resolution footprinting of sequence-specific protein-DNA contacts. Nat Biotechnol (2002) 1.17
A structural model for the damage-sensing complex in bacterial nucleotide excision repair. J Biol Chem (2009) 1.16
Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Am J Physiol Cell Physiol (2002) 1.16
Transcatheter closure of atrial septal defects in adults > or =40 years of age: immediate and follow-up results. J Interv Cardiol (2007) 1.14
ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol (2002) 1.13
Temporal trends of postinjury multiple-organ failure: still resource intensive, morbid, and lethal. J Trauma Acute Care Surg (2014) 1.11
All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples. J Am Chem Soc (2009) 1.10
Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract. J Bacteriol (2011) 1.10
Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4. J Appl Physiol (1985) (2008) 1.09
ClpP of Streptococcus mutans differentially regulates expression of genomic islands, mutacin production, and antibiotic tolerance. J Bacteriol (2009) 1.09
Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc (2008) 1.09
Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase. Proc Natl Acad Sci U S A (2009) 1.08
Monocyte chemotactic protein-1 directly induces human vascular smooth muscle proliferation. Am J Physiol Heart Circ Physiol (2002) 1.08
Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays. Ann Surg (2016) 1.07
Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock (2013) 1.07
Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. Structure (2008) 1.07
Retracted TLR4-dependent NF-kappaB activation and mitogen- and stress-activated protein kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans-isomerase (HP0175)-mediated induction of IL-6 release from macrophages. J Immunol (2006) 1.07
Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking. Chem Biol (2002) 1.07
Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg (2008) 1.06
Bioactivity of postshock mesenteric lymph depends on the depth and duration of hemorrhagic shock. Shock (2006) 1.06
Acute kidney injury and posttrauma multiple organ failure: the canary in the coal mine. J Trauma Acute Care Surg (2012) 1.05
HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive Care Med (2007) 1.04
A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell (2005) 1.03
Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice. Transl Stroke Res (2013) 1.03
Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. J Biol Chem (2009) 1.03
Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species. J Trauma (2004) 1.03
Systemic inflammatory changes and increased oxidative stress in rural Indian women cooking with biomass fuels. Toxicol Appl Pharmacol (2012) 1.03
The human cytomegalovirus UL44 C clamp wraps around DNA. Structure (2008) 1.02
Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg (2013) 1.02
Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation. J Leukoc Biol (2002) 1.01
Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes. Surgery (2011) 1.00
Proteomic analysis of human mesenteric lymph. Shock (2011) 0.98
Insights from studies of blood substitutes in trauma. Shock (2005) 0.98
Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg (2015) 0.98
The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem (2008) 0.97
Plasma first in the field for postinjury hemorrhagic shock. Shock (2014) 0.97
Proteomic analyses of human plasma: Venus versus Mars. Transfusion (2011) 0.95
Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1. J Biol Chem (2012) 0.95
Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides. Bioorg Med Chem Lett (2009) 0.94
Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs. Biochem J (2010) 0.93
Structure of Escherichia coli AlkA in complex with undamaged DNA. J Biol Chem (2010) 0.93