Published in Am J Physiol Lung Cell Mol Physiol on April 30, 2004
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature (2008) 4.85
Acute lower respiratory tract infection. N Engl J Med (2008) 3.70
The airway epithelium in asthma. Nat Med (2012) 2.86
Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04
Orchestrating house dust mite-associated allergy in the lung. Trends Immunol (2011) 1.86
Innate immunity in the lungs. Proc Am Thorac Soc (2005) 1.66
Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect Immun (2005) 1.51
Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant? Infect Immun (2007) 1.50
Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism. J Immunol (2007) 1.40
Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39
New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol (2009) 1.23
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide. Respir Res (2005) 1.21
Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med (2009) 1.17
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11
Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4. J Immunol (2010) 1.10
TLR2-mediated activation of neutrophils in response to German cockroach frass. J Immunol (2008) 1.08
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2009) 1.06
Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2. J Biol Chem (2008) 1.05
Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir Res (2009) 1.02
Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun (2012) 1.02
Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2. Ann Surg (2007) 1.01
Guilt by intimate association: what makes an allergen an allergen? J Allergy Clin Immunol (2010) 1.00
TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens. Front Immunol (2014) 0.97
Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2. J Immunol (2009) 0.96
Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway. PLoS One (2010) 0.96
RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol (2009) 0.94
Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness. Immunol Cell Biol (2008) 0.93
Allergen-specific pattern recognition receptor pathways. Curr Opin Immunol (2010) 0.92
Innate immune responses in house dust mite allergy. ISRN Allergy (2013) 0.92
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. Respir Res (2011) 0.88
Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor. Mediators Inflamm (2010) 0.88
Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J (2010) 0.87
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection. J Virol (2013) 0.86
Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins. Immunol Res (2014) 0.86
Effects of lipopolysaccharide and Mannheimia haemolytica leukotoxin on bovine lung microvascular endothelial cells and alveolar epithelial cells. Clin Vaccine Immunol (2007) 0.85
Do lipids influence the allergic sensitization process? J Allergy Clin Immunol (2014) 0.83
SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci U S A (2012) 0.83
Der p2 Internalization by Epithelium Synergistically Augments Toll-like Receptor-Mediated Proinflammatory Signaling. Allergy Asthma Immunol Res (2015) 0.82
Control of local immunity by airway epithelial cells. Mucosal Immunol (2015) 0.81
cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2014) 0.80
Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation. J Immunol (2015) 0.80
Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4. Innate Immun (2013) 0.78
House Dust Mite Allergens and the Induction of Monocyte Interleukin 1β Production That Triggers an IκBζ-Dependent Granulocyte Macrophage Colony-Stimulating Factor Release from Human Lung Epithelial Cells. Am J Respir Cell Mol Biol (2015) 0.77
Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues. Adv Carbohydr Chem Biochem (2014) 0.77
Primary Paediatric Bronchial Airway Epithelial Cell in Vitro Responses to Environmental Exposures. Int J Environ Res Public Health (2016) 0.76
Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. FASEB J (2016) 0.75
Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response. Clin Transl Allergy (2015) 0.75
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature (2008) 4.85
Motile cilia of human airway epithelia are chemosensory. Science (2009) 4.40
Microbial factor-mediated development in a host-bacterial mutualism. Science (2004) 3.63
Current prospects for RNA interference-based therapies. Nat Rev Genet (2011) 3.63
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature (2011) 2.94
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare. Annu Rev Microbiol (2006) 2.68
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest (2008) 2.21
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem (2001) 2.20
Neutrophil elastase targets virulence factors of enterobacteria. Nature (2002) 2.17
Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J Allergy Clin Immunol (2005) 1.99
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. Clin Microbiol Rev (2004) 1.93
Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol (2007) 1.93
Novel modification of lipid A of Francisella tularensis. Infect Immun (2004) 1.91
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91
Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90
Bacterial bioluminescence regulates expression of a host cryptochrome gene in the squid-Vibrio symbiosis. MBio (2013) 1.90
Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents (2003) 1.84
The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis. Mol Microbiol (2003) 1.84
[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80
The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature (2013) 1.78
Molecular basis of reduced potency of underacylated endotoxins. J Immunol (2005) 1.77
Roles of Vibrio fischeri and nonsymbiotic bacteria in the dynamics of mucus secretion during symbiont colonization of the Euprymna scolopes light organ. Appl Environ Microbiol (2002) 1.67
Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect Immun (2005) 1.65
Intestinal helminths protect in a murine model of asthma. J Immunol (2006) 1.64
Analysis of nontypeable haemophilus influenzae phase-variable genes during experimental human nasopharyngeal colonization. J Infect Dis (2013) 1.64
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation. J Biol Chem (2002) 1.60
Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57
Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. Am J Respir Crit Care Med (2006) 1.56
Health effects of airborne exposures from concentrated animal feeding operations. Environ Health Perspect (2006) 1.52
Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different lifestyles. J Infect Dis (2004) 1.51
Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia. Proc Natl Acad Sci U S A (2008) 1.49
Safety and immunological outcomes following human inoculation with nontypeable Haemophilus influenzae. J Infect Dis (2013) 1.48
Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog (2009) 1.48
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45
Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol (2003) 1.45
Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol (2013) 1.45
PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
Characterization of the OxyR regulon of Neisseria gonorrhoeae. Mol Microbiol (2006) 1.40
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J Biol Chem (2009) 1.38
Placebo response in asthma: a robust and objective phenomenon. J Allergy Clin Immunol (2007) 1.38
Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain. J Biol Chem (2006) 1.36
Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment. Microbiol Mol Biol Rev (2006) 1.36
Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin. J Biol Chem (2007) 1.36
piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A (2013) 1.35
Intracellular survival of Neisseria gonorrhoeae in male urethral epithelial cells: importance of a hexaacyl lipid A. Infect Immun (2002) 1.34
Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol (2010) 1.33
Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis. Infect Immun (2008) 1.31
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30
Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes. Infect Immun (2005) 1.29
CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25
Novel sialic acid transporter of Haemophilus influenzae. Infect Immun (2005) 1.25
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24
Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun (2010) 1.23
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Infection of human urethral epithelium with Neisseria gonorrhoeae elicits an upregulation of host anti-apoptotic factors and protects cells from staurosporine-induced apoptosis. Cell Microbiol (2003) 1.21
Gonococcal cervicitis: a role for biofilm in pathogenesis. J Infect Dis (2008) 1.20
Integration site choice of a feline immunodeficiency virus vector. J Virol (2006) 1.20
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20
Immortalization of human urethral epithelial cells: a model for the study of the pathogenesis of and the inflammatory cytokine response to Neisseria gonorrhoeae infection. Infect Immun (2002) 1.19
Acylation of the lipooligosaccharide of Haemophilus influenzae and colonization: an htrB mutation diminishes the colonization of human airway epithelial cells. Infect Immun (2002) 1.19
Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J Virol (2002) 1.18
A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells. Cell Microbiol (2002) 1.18
Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol (2005) 1.18
The Neisseria gonorrhoeae biofilm matrix contains DNA, and an endogenous nuclease controls its incorporation. Infect Immun (2011) 1.17
Basis for the failure of Francisella tularensis lipopolysaccharide to prime human polymorphonuclear leukocytes. Infect Immun (2006) 1.17
Expression and activity of beta-defensins and LL-37 in the developing human lung. J Immunol (2005) 1.17
The lipo-oligosaccharides of Haemophilus influenzae: an interesting array of characters. J Endotoxin Res (2003) 1.17
In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol (2002) 1.16
OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae. Infect Immun (2003) 1.16
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15
CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. J Allergy Clin Immunol (2002) 1.15
Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev (2009) 1.14
Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood (2005) 1.14
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
NmlR of Neisseria gonorrhoeae: a novel redox responsive transcription factor from the MerR family. Mol Microbiol (2005) 1.13
PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13
Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med (2004) 1.12
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12
Role of lgtC in resistance of nontypeable Haemophilus influenzae strain R2866 to human serum. Infect Immun (2006) 1.12