Published in PLoS Biol on May 11, 2004
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35
The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol (2009) 3.50
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell (2007) 2.30
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol (2008) 2.21
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
Involvement of novel autophosphorylation sites in ATM activation. EMBO J (2006) 1.94
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Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med (2009) 1.54
Disruption of mechanisms that prevent rereplication triggers a DNA damage response. Mol Cell Biol (2005) 1.51
Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics (2005) 1.48
Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell (2005) 1.39
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32
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An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol (2009) 1.05
A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint. Proc Natl Acad Sci U S A (2009) 1.04
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem (2009) 0.99
MCL-1 localizes to sites of DNA damage and regulates DNA damage response. Cell Cycle (2010) 0.98
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem (2013) 0.96
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cell Mol Life Sci (2014) 0.95
Dynamic structures of Bacillus subtilis RecN-DNA complexes. Nucleic Acids Res (2007) 0.94
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) (2009) 0.90
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open (2012) 0.88
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses. J Biol Chem (2012) 0.86
DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii. Mol Microbiol (2012) 0.85
Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae. PLoS One (2013) 0.81
The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell (2013) 0.79
Ploidy dictates repair pathway choice under DNA replication stress. Genetics (2011) 0.79
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NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
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ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem (2001) 8.78
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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
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Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55
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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell (2001) 3.81
DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol (2001) 3.78
Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol Cell (2001) 3.66
ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66
Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell (2001) 2.65
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem (2001) 2.65
Trading places on DNA--a three-point switch underlies primer handoff from primase to the replicative DNA polymerase. Cell (1999) 2.51
Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem (2001) 2.43
DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res (2003) 2.23
Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem (2002) 2.13
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res (2001) 2.05
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The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. Proc Natl Acad Sci U S A (2001) 1.61
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ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol (2004) 4.39
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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell (2003) 2.96
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol (2010) 2.92
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Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol (2006) 2.09
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Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell (2009) 1.92
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ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle (2005) 1.27
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Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. EMBO J (2005) 1.22
Early neural cell death: dying to become neurons. Dev Biol (2004) 1.20
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Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep (2013) 1.16
Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. EMBO J (2008) 1.14
Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. Cell Cycle (2003) 1.09
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The DNA damage response during an unperturbed S-phase. DNA Repair (Amst) (2007) 1.05
Studies of the properties of human origin recognition complex and its Walker A motif mutants. Proc Natl Acad Sci U S A (2004) 1.04
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. J Biol Chem (2008) 1.03
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
Replication-independent repair of DNA interstrand crosslinks. Mol Cell (2012) 0.95
Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development. Photochem Photobiol (2002) 0.93
The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol (2004) 0.92
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem (2005) 0.92
Xenopus cell-free extracts to study DNA damage checkpoints. Methods Mol Biol (2004) 0.92
Xenopus cell-free extracts to study the DNA damage response. Methods Mol Biol (2004) 0.90
The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol (2010) 0.90
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) (2009) 0.90
DNA repair: tails of histones lost. Nature (2006) 0.89
A role for programmed cell death during early neurogenesis in xenopus. Dev Biol (2003) 0.88
MCM proteins and checkpoint kinases get together at the fork. Proc Natl Acad Sci U S A (2004) 0.88
The differences between ICL repair during and outside of S phase. Trends Biochem Sci (2013) 0.88
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Study of cell cycle checkpoints using Xenopus cell-free extracts. Methods Mol Biol (2011) 0.81
Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53. J Invest Dermatol (2002) 0.80
The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell (2013) 0.79
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Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas. Biochem Biophys Res Commun (2002) 0.78
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