Published in Science on May 14, 2004
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98
Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity (2007) 5.36
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med (2005) 3.42
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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature (2011) 2.93
Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol (2005) 2.89
TLR signaling is required for Salmonella typhimurium virulence. Cell (2011) 2.88
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci (2009) 2.69
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest (2006) 2.59
Modulation of adaptive immunity with Toll-like receptors. Semin Immunol (2009) 2.56
Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol (2008) 2.53
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med (2005) 2.50
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30
The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med (2009) 2.21
A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol (2008) 2.20
Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses. J Immunol (2010) 2.09
Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol (2011) 1.98
Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect Immun (2007) 1.98
Regulation of innate immune responses by autophagy-related proteins. J Cell Biol (2010) 1.94
Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles. Immunology (2006) 1.92
Systems biology of innate immunity. Immunol Rev (2009) 1.87
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection. PLoS One (2007) 1.82
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.82
A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester. J Immunol Methods (2009) 1.78
Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice. Infect Immun (2004) 1.72
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine (2009) 1.72
Mycobacterium tuberculosis and the intimate discourse of a chronic infection. Immunol Rev (2011) 1.72
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways. J Immunol (2008) 1.64
Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity (2012) 1.59
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med (2008) 1.56
The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol (2010) 1.55
Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52
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An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells. Nat Nanotechnol (2015) 1.50
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem (2008) 1.49
Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci (2007) 1.49
TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe (2007) 1.47
Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs. PLoS One (2008) 1.44
The macrophage marches on its phagosome: dynamic assays of phagosome function. Nat Rev Immunol (2009) 1.43
C-type lectins and phagocytosis. Immunobiology (2009) 1.41
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun (2008) 1.40
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol (2013) 1.39
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus. J Immunol (2010) 1.38
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog (2009) 1.37
Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ (2007) 1.35
Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog (2008) 1.34
MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One (2008) 1.33
The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells. Cell Microbiol (2008) 1.30
Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice. J Cell Biol (2004) 1.29
Innovative strategies for co-delivering antigens and CpG oligonucleotides. Adv Drug Deliv Rev (2009) 1.28
Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS One (2010) 1.28
Toll-like receptors in the skin. Semin Immunopathol (2007) 1.27
Toll-like receptors in Alzheimer's disease. Curr Top Microbiol Immunol (2009) 1.27
Toll-like receptors: key players in antiviral immunity. Curr Opin Virol (2011) 1.24
Immunoregulation of dendritic cells. Clin Med Res (2005) 1.23
Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol (2005) 1.23
Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis. J Immunol (2009) 1.22
Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function. Cell Microbiol (2013) 1.21
TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood (2011) 1.21
The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila. Proc Natl Acad Sci U S A (2006) 1.20
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. FASEB J (2010) 1.19
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
MHC molecules and microbial antigen processing in phagosomes. Curr Opin Immunol (2009) 1.16
Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol (2008) 1.16
Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol (2008) 1.16
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci U S A (2011) 1.15
Phagosome maturation during the removal of apoptotic cells: receptors lead the way. Trends Cell Biol (2008) 1.15
Autophagy proteins in macroendocytic engulfment. Trends Cell Biol (2012) 1.15
Toll-like receptor 4 activation in cancer progression and therapy. Clin Dev Immunol (2011) 1.14
Pathogen recognition receptors, cancer and inflammation in the gut. Curr Opin Pharmacol (2009) 1.14
Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block. Infect Immun (2008) 1.14
Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes. Infect Immun (2005) 1.13
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Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol (2009) 1.12
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Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens. J Clin Invest (2011) 1.11
Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling. Antioxid Redox Signal (2012) 1.11
Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep (2010) 1.11
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proc Natl Acad Sci U S A (2006) 1.10
Synthetic Nanoparticles for Vaccines and Immunotherapy. Chem Rev (2015) 1.10
Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival. Infect Immun (2006) 1.09
Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages. Infect Immun (2010) 1.09
Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells. PLoS One (2009) 1.09
The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J (2010) 1.09
Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun (2009) 1.08
Immune recognition of Streptococcus pyogenes by dendritic cells. Infect Immun (2008) 1.07
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. J Immunol (2010) 1.07
Activation and regulation of toll-like receptors (TLRs) by helminth parasites. Immunol Res (2009) 1.07
Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cells. Infect Immun (2008) 1.07
Retracted B7-DC cross-linking restores antigen uptake and augments antigen-presenting cell function by matured dendritic cells. Proc Natl Acad Sci U S A (2005) 1.07
An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. Proc Natl Acad Sci U S A (2008) 1.07
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. J Biol Chem (2012) 1.07
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
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Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34
Type I interferons in host defense. Immunity (2006) 7.32
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
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Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54
Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98
Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11
Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90
Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88
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Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11
Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09
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Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47
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Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38
Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36
Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35
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Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33
Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
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Learning tolerance while fighting ignorance. Cell (2009) 1.20
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Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97
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Antifungal defense turns 17. Nat Immunol (2007) 0.93
Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90
Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89
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A new shield for a cytokine storm. Cell (2011) 0.88
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Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76
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