Published in J Biol Chem on May 18, 2004
Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31
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Protein kinase C-theta is required for development of experimental cerebral malaria. Am J Pathol (2010) 0.89
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The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A (2002) 2.93
Requirement for CDK4 kinase function in breast cancer. Cancer Cell (2006) 2.92
Protein kinase C(theta) in T cell activation. Annu Rev Immunol (2002) 2.68
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The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol (2004) 2.19
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Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood (2008) 1.95
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature (2008) 1.85
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes (2006) 1.84
Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81
Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. JAMA (2003) 1.81
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79
Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A (2010) 1.75
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity (2006) 1.75
Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem (2002) 1.72
Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem (2001) 1.71
Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide. J Biol Chem (2006) 1.70
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell (2006) 1.69
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Fibrocyte activation in rheumatoid arthritis. Rheumatology (Oxford) (2009) 1.68
Chemokines: attractive mediators of the immune response. Semin Immunol (2003) 1.66
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Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66
Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis. Arthritis Rheum (2012) 1.65
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Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A (2006) 1.54
Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma (2009) 1.53
Jak family of kinases in cancer. Cancer Metastasis Rev (2003) 1.52
Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev (2002) 1.49
Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood (2006) 1.48
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2002) 1.47
Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J Immunol (2002) 1.41
Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. J Biol Chem (2006) 1.41
Protective role for interferon-beta in coxsackievirus B3 infection. Circulation (2004) 1.40
Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res (2005) 1.40
Therapeutic implications for interferon-alpha in arthritis: a pilot study. J Rheumatol (2003) 1.39
Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood (2003) 1.37
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36
Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells. Endocrinology (2003) 1.35
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. Mol Cell Biol (2004) 1.35
Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol (2002) 1.35
Statins in tumor suppression. Cancer Lett (2008) 1.34
Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J Immunol (2004) 1.32
Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene (2002) 1.32
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res (2006) 1.31
Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. FASEB J (2004) 1.30
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol (2011) 1.30
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J (2004) 1.30
Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clin Cancer Res (2011) 1.29
The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. J Biol Chem (2004) 1.29
Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PLoS One (2010) 1.29
Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J (2002) 1.28
Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther (2008) 1.28
Sex differences in the vaccine-specific and non-targeted effects of vaccines. Vaccine (2011) 1.27
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood (2013) 1.26
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SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity (2003) 1.26
SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling. J Clin Invest (2007) 1.26
The yin and yang of viruses and interferons. Trends Immunol (2012) 1.25
Activation of protein kinase C delta by IFN-gamma. J Immunol (2003) 1.25
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25
Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation. Am J Pathol (2002) 1.24
The p38 mitogen-activated protein kinase pathway in interferon signal transduction. J Interferon Cytokine Res (2005) 1.23
Role of p38alpha Map kinase in Type I interferon signaling. J Biol Chem (2003) 1.23
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J Immunol (2008) 1.22