Published in Genes Dev on May 15, 2004
Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. Nat Cell Biol (2006) 1.63
Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest (2006) 1.63
Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell (2017) 1.45
Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One (2016) 1.41
Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling. PLoS One (2007) 1.26
Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development (2011) 1.14
Teasing out T-box targets in early mesoderm. Curr Opin Genet Dev (2008) 1.13
Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. J Invest Dermatol (2012) 1.13
Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol (2012) 1.10
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PLoS One (2010) 1.08
T-box factors determine cardiac design. Cell Mol Life Sci (2007) 1.04
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One (2011) 1.03
Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development (2011) 1.03
Tgfbr2 regulates the maintenance of boundaries in the axial skeleton. Dev Biol (2006) 1.01
Tcf21 regulates the specification and maturation of proepicardial cells. Development (2013) 0.98
The T-box gene family: emerging roles in development, stem cells and cancer. Development (2014) 0.96
Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice. PLoS One (2012) 0.95
Expression of somite segmentation genes in amphioxus: a clock without a wavefront? Dev Genes Evol (2008) 0.93
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells. PLoS One (2013) 0.93
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev Biol (2009) 0.92
Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators. Mol Cell Biol (2008) 0.92
Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One (2013) 0.92
Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet (2013) 0.91
Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development (2013) 0.89
Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiation. Differentiation (2010) 0.88
Tbx18 regulates development of the epicardium and coronary vessels. Dev Biol (2013) 0.87
The mouse notches up another success: understanding the causes of human vertebral malformation. Mamm Genome (2011) 0.86
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet (2013) 0.86
Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Biol Open (2012) 0.85
Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol (2014) 0.85
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol (2015) 0.84
Smooth muscle differentiation and patterning in the urinary bladder. Differentiation (2010) 0.84
Myocardin marks the earliest cardiac gene expression and plays an important role in heart development. Anat Rec (Hoboken) (2008) 0.83
Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex. BMC Dev Biol (2007) 0.83
Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet (2015) 0.83
Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat. PLoS One (2014) 0.82
From dynamic expression patterns to boundary formation in the presomitic mesoderm. PLoS Comput Biol (2012) 0.81
Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A (2013) 0.79
Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. BMC Dev Biol (2007) 0.78
A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues. Dev Biol (2014) 0.77
Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development (2016) 0.76
Supt20 is required for development of the axial skeleton. Dev Biol (2016) 0.75
Diversification of Cell Lineages in Ureter Development. J Am Soc Nephrol (2016) 0.75
Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development. PLoS One (2016) 0.75
A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev (1989) 5.91
Notch1 is required for the coordinate segmentation of somites. Development (1995) 4.33
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev (1993) 3.93
Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis (2000) 3.71
Maintenance of somite borders in mice requires the Delta homologue DII1. Nature (1997) 3.44
Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development (1992) 2.43
Notch2: a second mammalian Notch gene. Development (1992) 2.28
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development (1994) 2.27
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development (1995) 2.20
Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron (1997) 2.15
Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell (1988) 2.05
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development (1997) 2.03
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev (1997) 1.97
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
Cloning and expression analysis of the mouse T-box gene Tbx18. Mech Dev (2001) 1.93
The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet (2001) 1.88
Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev Biol (1995) 1.87
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol (1999) 1.73
Vertebrate somitogenesis. Annu Rev Cell Dev Biol (2001) 1.67
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development (2002) 1.66
Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mech Dev (1995) 1.48
The migration of neural crest cells and the growth of motor axons through the rostral half of the chick somite. J Embryol Exp Morphol (1985) 1.45
Segmentation in the vertebrate nervous system. Nature (1984) 1.43
Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system. Dev Dyn (1997) 1.41
Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol (1998) 1.41
sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn (1998) 1.37
Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9. Development (2000) 1.37
Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev Biol (1995) 1.36
Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development (2003) 1.32
A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development (1992) 1.31
Mechanisms of vertebrate segmentation. Development (1988) 1.31
A Notch feeling of somite segmentation and beyond. Dev Biol (2004) 1.28
Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet (2000) 1.25
Interactions between somite cells: the formation and maintenance of segment boundaries in the chick embryo. Development (1987) 1.24
Distinct regulatory elements direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice. Mech Dev (2000) 1.23
The development of the vertebral column. Adv Anat Embryol Cell Biol (1985) 1.23
The development of the avian vertebral column. Anat Embryol (Berl) (2000) 1.19
The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development (2000) 1.17
Adhesive subdivisions intrinsic to the epithelial somites. Dev Biol (1999) 1.01
The developmental fate of the rostral/caudal half of a somite for vertebra and rib formation: experimental confirmation of the resegmentation theory using chick-quail chimeras. Mech Dev (2000) 1.01
New experimental evidence for somite resegmentation. Anat Embryol (Berl) (2000) 0.97
Determination of epithelial half-somites in skeletal morphogenesis. Development (1992) 0.92
Segmental identity can change independently in the hindbrain and rhombencephalic neural crest. Dev Dyn (1997) 0.89
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet (2006) 5.29
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nat Genet (2002) 4.64
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet (2003) 4.14
Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1. J Biol Chem (2003) 3.68
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Nat Genet (2005) 3.55
Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum Mol Genet (2004) 2.63
Tbx18 and the fate of epicardial progenitors. Nature (2009) 2.42
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med (2003) 2.30
Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem (2003) 2.28
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest (2011) 2.21
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest (2007) 2.17
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell (2008) 2.12
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet (2010) 2.12
Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. Am J Hum Genet (2009) 2.10
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood (2009) 2.07
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell (2006) 2.06
Okihiro syndrome is caused by SALL4 mutations. Hum Mol Genet (2002) 2.06
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity (2008) 2.05
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol (2002) 2.03
The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res (2009) 2.02
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol (2006) 1.91
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3. Circ Res (2008) 1.90
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res (2005) 1.86
Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development (2005) 1.85
Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature (2002) 1.84
Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation. Hepatology (2009) 1.80
Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol (2009) 1.79
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 1.76
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A (2006) 1.76
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74
Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns (2002) 1.72
Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res (2006) 1.70
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell (2013) 1.68
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome. Am J Hum Genet (2008) 1.68
Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell (2011) 1.67
Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res (2005) 1.65
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism (2012) 1.63
Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest (2006) 1.63
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development (2005) 1.61
Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci (2006) 1.61
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell (2007) 1.59
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res (2009) 1.58
Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res (2007) 1.54
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood (2011) 1.53
PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. Arterioscler Thromb Vasc Biol (2013) 1.52
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem (2004) 1.49
Development of the pacemaker tissues of the heart. Circ Res (2010) 1.46
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling. Cardiovasc Res (2013) 1.45
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell (2013) 1.44
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature (2004) 1.43
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell (2006) 1.41
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res (2009) 1.40
Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev Biol (2007) 1.40
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol (2007) 1.39
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol (2011) 1.37
The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev (2005) 1.35
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proc Natl Acad Sci U S A (2005) 1.34
Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res (2011) 1.34
Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol (2004) 1.34
Mechanisms of T-box gene function in the developing heart. Cardiovasc Res (2011) 1.33
12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol (2007) 1.32
Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development (2003) 1.32
Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. J Biol Chem (2007) 1.31
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31
A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell (2013) 1.30
Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev (2003) 1.29
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc Natl Acad Sci U S A (2003) 1.28
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res (2006) 1.27