Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.
|
Science
|
2011
|
2.55
|
2
|
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
|
Nat Chem Biol
|
2008
|
1.96
|
3
|
Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid.
|
Biochemistry
|
2004
|
1.67
|
4
|
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase.
|
J Am Chem Soc
|
2011
|
1.62
|
5
|
Structural basis for methyl transfer by a radical SAM enzyme.
|
Science
|
2011
|
1.61
|
6
|
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases.
|
Biochemistry
|
2012
|
1.60
|
7
|
Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase.
|
J Am Chem Soc
|
2011
|
1.54
|
8
|
Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.
|
Proc Natl Acad Sci U S A
|
2009
|
1.47
|
9
|
In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters.
|
Biochemistry
|
2008
|
1.46
|
10
|
Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine.
|
Biochemistry
|
2004
|
1.36
|
11
|
Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide.
|
J Am Chem Soc
|
2005
|
1.36
|
12
|
Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide.
|
Biochemistry
|
2004
|
1.35
|
13
|
Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily.
|
Biochemistry
|
2009
|
1.33
|
14
|
Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins.
|
Curr Opin Chem Biol
|
2011
|
1.19
|
15
|
A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters.
|
Biochemistry
|
2010
|
1.13
|
16
|
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification.
|
Proc Natl Acad Sci U S A
|
2013
|
1.08
|
17
|
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.
|
J Am Chem Soc
|
2011
|
1.07
|
18
|
RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins.
|
Methods Enzymol
|
2012
|
1.03
|
19
|
Identification and function of auxiliary iron-sulfur clusters in radical SAM enzymes.
|
Biochim Biophys Acta
|
2012
|
1.02
|
20
|
Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase.
|
Biochemistry
|
2004
|
1.01
|
21
|
Mechanistic and functional versatility of radical SAM enzymes.
|
F1000 Biol Rep
|
2010
|
0.98
|
22
|
Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis.
|
Biochemistry
|
2013
|
0.95
|
23
|
A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr.
|
Nat Chem Biol
|
2013
|
0.93
|
24
|
Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster.
|
J Am Chem Soc
|
2005
|
0.93
|
25
|
X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
|
Proc Natl Acad Sci U S A
|
2013
|
0.93
|
26
|
Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis.
|
J Biol Chem
|
2004
|
0.91
|
27
|
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
|
Protein Expr Purif
|
2005
|
0.91
|
28
|
Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes.
|
Biochemistry
|
2008
|
0.87
|
29
|
Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.
|
J Am Chem Soc
|
2016
|
0.86
|
30
|
A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases.
|
Proc Natl Acad Sci U S A
|
2013
|
0.85
|
31
|
Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase.
|
Biochemistry
|
2014
|
0.85
|
32
|
Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN.
|
J Am Chem Soc
|
2014
|
0.83
|
33
|
Biochemistry: The ylide has landed.
|
Nature
|
2013
|
0.82
|
34
|
The activity of Escherichia coli cyclopropane fatty acid synthase depends on the presence of bicarbonate.
|
J Am Chem Soc
|
2005
|
0.81
|
35
|
Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation.
|
Biochemistry
|
2008
|
0.80
|
36
|
Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase.
|
Biochemistry
|
2015
|
0.77
|
37
|
Electrochemical Resolution of the [4Fe-4S] Centers of the AdoMet Radical Enzyme BtrN: Evidence of Proton Coupling and an Unusual, Low-Potential Auxiliary Cluster.
|
J Am Chem Soc
|
2015
|
0.76
|
38
|
Transformations of the FeS Clusters of the Methylthiotransferases MiaB and RimO, Detected by Direct Electrochemistry.
|
Biochemistry
|
2016
|
0.76
|
39
|
Enzymology: Radical break-up, blissful make-up.
|
Nat Chem Biol
|
2011
|
0.75
|
40
|
The Radical S-Adenosylmethionine Methylase NosN Catalyzes both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide.
|
J Am Chem Soc
|
2017
|
0.75
|