Why biophysicists make models: quantifying modulation of the M current.

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Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron (2002) 4.58

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron (2003) 4.46

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AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08

Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol (2003) 1.95

M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci (2001) 1.94

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Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neurons. Proc Natl Acad Sci U S A (1998) 1.74

M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci (2004) 1.66

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Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11. Neuron (1995) 1.35

Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels. Br J Pharmacol (2002) 1.34

The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. J Neurosci (1998) 1.30

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Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons. J Neurosci (2003) 1.09

Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons. Neuron (1993) 1.06

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M-channel gating and simulation. Biophys J (1999) 1.04

Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels. J Neurosci (2002) 0.98

Visualizing phosphoinositide signalling in single neurons gets a green light. Trends Neurosci (2003) 0.93