Published in Photochem Photobiol on May 01, 2004
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The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci (2009) 1.31
SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2005) 1.22
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(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
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Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis. Proc Natl Acad Sci U S A (2006) 1.04
A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies. Br J Ophthalmol (2006) 1.00
The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res (2010) 0.99
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Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study. PLoS One (2012) 0.94
Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2008) 0.92
Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Mol Endocrinol (2011) 0.91
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest Ophthalmol Vis Sci (2009) 0.91
MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells. PLoS One (2012) 0.89
The influence of sublethal blue light exposure on human RPE cells. Mol Vis (2009) 0.88
The influence of visible light exposure on cultured RGC-5 cells. Mol Vis (2007) 0.88
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Superoxide dismutase1 levels in North Indian population with age-related macular degeneration. Oxid Med Cell Longev (2013) 0.87
Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis (2011) 0.87
Visible light alters yeast metabolic rhythms by inhibiting respiration. Proc Natl Acad Sci U S A (2013) 0.86
Sublethal photic stress and the motility of RPE phagosomes and melanosomes. Invest Ophthalmol Vis Sci (2008) 0.86
Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death. Cell Death Dis (2014) 0.86
Stress reaction in outer segments of photoreceptors after blue light irradiation. PLoS One (2013) 0.84
AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol (2008) 0.82
Influence of blue light on photoreceptors in a live retinal explant system. Mol Vis (2011) 0.82
Mitigating phototoxicity during multiphoton microscopy of live Drosophila embryos in the 1.0-1.2 µm wavelength range. PLoS One (2014) 0.82
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81
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An in vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines. Photochem Photobiol Sci (2016) 0.79
Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. Int J Mol Sci (2014) 0.79
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Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species. Biochim Biophys Acta (2014) 0.78
The effect of blue light exposure in an ocular melanoma animal model. J Exp Clin Cancer Res (2009) 0.78
Relationship between Oxidative Stress, Circadian Rhythms, and AMD. Oxid Med Cell Longev (2015) 0.78
Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405 nm). Eye (Lond) (2014) 0.77
Evidence for the Role of Blue Light in the Development of Uveal Melanoma. J Ophthalmol (2015) 0.77
Molecular imaging of retinal disease. J Ocul Pharmacol Ther (2013) 0.76
Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons. Pflugers Arch (2015) 0.75
Activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway in human lung cancer cells by the new synthetic flavonoid, LZ-205. Oncotarget (2016) 0.75
Upregulation of GADD45α in light-damaged retinal pigment epithelial cells. Cell Death Discov (2016) 0.75
Photosensitive fluorescent dye contributes to phototoxicity and inflammatory responses of dye-doped silica NPs in cells and mice. Theranostics (2014) 0.75
Evaluating the Biostability of Yellow and Clear Intraocular Lenses with a System Simulating Natural Intraocular Environment. Transl Vis Sci Technol (2016) 0.75
Light-emitting-diode induced retinal damage and its wavelength dependency in vivo. Int J Ophthalmol (2017) 0.75
Mechanisms of bystander effects in retinal pigment epithelium cell networks. Cell Death Dis (2017) 0.75
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IL-21 is required to control chronic viral infection. Science (2009) 4.80
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32
Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol (2011) 3.65
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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol (2007) 3.33
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Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature (2016) 2.98
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell (2012) 2.82
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol (2002) 2.63
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med (2011) 2.48
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
Mitochondria in cancer: not just innocent bystanders. Semin Cancer Biol (2008) 2.23
Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci U S A (2003) 2.12
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Metabolic transformation in cancer. Carcinogenesis (2009) 2.07
Cardiolipin: setting the beat of apoptosis. Apoptosis (2007) 2.06
Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol (2008) 2.06
Inborn and acquired metabolic defects in cancer. J Mol Med (Berl) (2011) 2.06
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci U S A (2004) 1.97
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 1.96
Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol (2002) 1.93
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci (2012) 1.89
Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol (2003) 1.87
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS One (2011) 1.86
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp (2004) 1.82
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol (2005) 1.82
Glutathionylation of mitochondrial proteins. Antioxid Redox Signal (2005) 1.79
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann Neurol (2013) 1.70
Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci (2010) 1.67
Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis (2003) 1.66
Mitochondria-targeted small molecule therapeutics and probes. Antioxid Redox Signal (2011) 1.66
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol (2011) 1.66
Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochim Biophys Acta (2009) 1.66
Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell (2013) 1.65
Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria. J Biol Chem (2006) 1.65
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med (2009) 1.62
mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest (2010) 1.61
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol (2013) 1.61
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A (2013) 1.60
Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch Ophthalmol (2003) 1.58
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol (2012) 1.55
The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med (2008) 1.55
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54
Light damage induced changes in mouse retinal gene expression. Exp Eye Res (2004) 1.54
Adhesion of biologically inspired vertical and angled polymer microfiber arrays. Langmuir (2007) 1.54
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells. Cell Cycle (2009) 1.54
A complication from neurocranial restructuring: nasal septum fracture. Arch Otolaryngol Head Neck Surg (2003) 1.53
Mitochondrial pharmacology. Trends Pharmacol Sci (2012) 1.51
A redox switch in angiotensinogen modulates angiotensin release. Nature (2010) 1.50
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci (2008) 1.47
Association of risk factors for choroidal neovascularization in age-related macular degeneration with decreased foveolar choroidal circulation. Am J Ophthalmol (2010) 1.47
Estimating the risk of solid organ malignancy in patients undergoing routine computed tomography scans after endovascular aneurysm repair. J Vasc Surg (2012) 1.46
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord (2007) 1.44
Femoral arterial access management for endovascular aortic aneurysm repair: evolution and outcome. Perspect Vasc Surg Endovasc Ther (2009) 1.42
Use of animals by NATO countries in military medical training exercises: an international survey. Mil Med (2012) 1.42
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Dialysis access steal syndromes. Perspect Vasc Surg Endovasc Ther (2009) 1.38
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem (2007) 1.38
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci (2011) 1.37
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J Biol Chem (2008) 1.36
How mitochondrial damage affects cell function. J Biomed Sci (2002) 1.34
Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biol (2013) 1.34
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33
Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci (2009) 1.32
Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci (2011) 1.32
Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res (2009) 1.31
Receptor for advanced glycation end products and age-related macular degeneration. Invest Ophthalmol Vis Sci (2004) 1.30
Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. Ophthalmology (2005) 1.29
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J (2008) 1.28
Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J (2010) 1.28