Published in Hum Mol Genet on June 22, 2004
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J (2006) 2.24
Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta (2005) 2.16
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A (2008) 2.01
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A (2006) 1.74
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54
Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45
Gap junctions and cochlear homeostasis. J Membr Biol (2006) 1.41
The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta (2012) 1.34
Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28
Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease. Mol Cell Neurosci (2007) 1.24
Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest (2006) 1.22
Voltage dependence of ATP secretion in mammalian taste cells. J Gen Physiol (2008) 1.19
The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity. Am J Physiol Cell Physiol (2013) 1.12
Gap junctions in inherited human disorders of the central nervous system. Biochim Biophys Acta (2011) 1.05
N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci (2006) 1.01
Gap junctions in inherited human disease. Pflugers Arch (2010) 0.97
GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss. Curr Genomics (2011) 0.96
An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci (2008) 0.95
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol (2007) 0.90
Pathological hemichannels associated with human Cx26 mutations causing Keratitis-Ichthyosis-Deafness syndrome. Biochim Biophys Acta (2011) 0.88
Connexons and pannexons: newcomers in neurophysiology. Front Cell Neurosci (2014) 0.88
The N terminus of connexin37 contains an alpha-helix that is required for channel function. J Biol Chem (2009) 0.87
EKV mutant connexin 31 associated cell death is mediated by ER stress. Hum Mol Genet (2009) 0.86
Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2. Elife (2014) 0.86
Diseases associated with leaky hemichannels. Front Cell Neurosci (2015) 0.84
Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer (2016) 0.83
Regulation of cellular function by connexin hemichannels. Int J Biochem Mol Biol (2011) 0.83
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. PLoS One (2012) 0.81
Phenotypic variability in gap junction syndromic skin disorders: experience from KID and Clouston syndromes' clinical diagnostics. J Appl Genet (2015) 0.81
Connexin channels in congenital skin disorders. Semin Cell Dev Biol (2016) 0.79
Connexin hemichannels influence genetically determined inflammatory and hyperproliferative skin diseases. Pharmacol Res (2015) 0.79
Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice. J Dermatol Sci (2015) 0.78
Possible role of hemichannels in cancer. Front Physiol (2014) 0.78
Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function. PLoS One (2014) 0.76
Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell (2016) 0.76
Human diseases associated with connexin mutations. Biochim Biophys Acta (2017) 0.75
A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics. Nat Commun (2017) 0.75
Defective channels lead to an impaired skin barrier. J Cell Sci (2014) 0.75
Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders. Front Mol Neurosci (2017) 0.75
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics. Neurochem Res (2017) 0.75
Connexin channel and its role in diabetic retinopathy. Prog Retin Eye Res (2017) 0.75
Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A (2003) 3.96
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol (2011) 3.04
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell (2010) 2.96
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell (2007) 2.81
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell (2009) 2.57
Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes (2005) 2.24
Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol (2005) 2.23
Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda) (2006) 2.13
Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes (2007) 1.97
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study. Lancet (2009) 1.91
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes (2010) 1.80
Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2. Hum Mol Genet (2003) 1.75
Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res (2007) 1.70
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. Hum Mol Genet (2002) 1.69
Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nat Cell Biol (2003) 1.66
Rhamnolipids are virulence factors that promote early infiltration of primary human airway epithelia by Pseudomonas aeruginosa. Infect Immun (2006) 1.52
Malignant deep brain stimulation-withdrawal syndrome in a patient with Parkinson's disease. Mov Disord (2013) 1.51
New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J (2006) 1.50
Open source clinical science for emerging infections. Lancet Infect Dis (2014) 1.47
Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. Mol Biol Cell (2005) 1.45
Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch (2008) 1.45
Restoration of connexin 40 (Cx40) in Renin-producing cells reduces the hypertension of Cx40 null mice. Hypertension (2014) 1.44
Targeting pannexin1 improves seizure outcome. PLoS One (2011) 1.43
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A (2007) 1.41
Role of Connexins and Pannexins in the Pancreas. Pancreas (2015) 1.39
Contribution of connexins to the function of the vascular wall. Cardiovasc Res (2004) 1.35
In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties. J Biomed Opt (2003) 1.34
Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32
Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks. Biochim Biophys Acta (2004) 1.31
Lipotoxicity disrupts incretin-regulated human β cell connectivity. J Clin Invest (2013) 1.27
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes (2011) 1.26
Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells. Diabetes (2003) 1.26
Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas. Diabetes (2007) 1.25
Human side population keratinocytes exhibit long-term proliferative potential and a specific gene expression profile and can form a pluristratified epidermis. Stem Cells (2005) 1.24
Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. Blood (2002) 1.22
Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes (2008) 1.17
Exocytosis of ATP from astrocyte progenitors modulates spontaneous Ca2+ oscillations and cell migration. Glia (2007) 1.16
Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction. Exp Cell Res (2002) 1.16
Connexins: key mediators of endocrine function. Physiol Rev (2011) 1.16
Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science (2007) 1.14
Pathogenetic role of the deafness-related M34T mutation of Cx26. Hum Mol Genet (2006) 1.14
Efficient assembly and secretion of recombinant subviral particles of the four dengue serotypes using native prM and E proteins. PLoS One (2009) 1.13
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet (2008) 1.12
Dissociation of decision-making under ambiguity and decision-making under risk in patients with Parkinson's disease: a neuropsychological and psychophysiological study. Neuropsychologia (2009) 1.12
Virtual cloning, functional expression, and gating analysis of human connexin31.9. Am J Physiol Cell Physiol (2002) 1.10
Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cells. J Neurosci (2003) 1.10
Hearing loss: frequency and functional studies of the most common connexin26 alleles. Biochem Biophys Res Commun (2002) 1.09
A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells. Exp Cell Res (2008) 1.09
Connexins protect mouse pancreatic β cells against apoptosis. J Clin Invest (2011) 1.08
H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. J Virol (2007) 1.08
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression. J Cell Sci (2004) 1.07
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis. Traffic (2008) 1.06
High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets. Diabetes (2011) 1.06
Low-dose exposure to gamma rays induces specific gene regulations in normal human keratinocytes. Radiat Res (2005) 1.06
Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets. Exp Cell Res (2004) 1.06
An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc Res (2010) 1.05
Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells. J Cell Sci (2002) 1.05
Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. PLoS One (2009) 1.05
Modulation of perch connexin35 hemi-channels by cyclic AMP requires a protein kinase A phosphorylation site. J Neurosci Res (2003) 1.04
Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. Hum Mutat (2005) 1.03
Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol (2009) 1.03
Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. J Biol Chem (2011) 1.02
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis. Mol Biol Cell (2010) 1.01
Connexin43-dependent mechanism modulates renin secretion and hypertension. J Clin Invest (2006) 1.00
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. Cancer Genet Cytogenet (2008) 0.99
Involvement of gap junctional communication in secretion. Biochim Biophys Acta (2005) 0.99
Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. J Biol Chem (2009) 0.98
p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J Biol Chem (2011) 0.98
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice. Diabetes (2011) 0.98
Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97
Task-specific modulation of effective connectivity during two simple unimanual motor tasks: a 122-channel EEG study. Neuroimage (2011) 0.97
The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression. Diabetes (2010) 0.96
Live imaging of neural structure and function by fibred fluorescence microscopy. EMBO Rep (2006) 0.96
The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G. Diabetes (2006) 0.96
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy (2013) 0.94
Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J Biol Chem (2002) 0.94
Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins. J Vasc Surg (2013) 0.93
Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway. J Virol (2011) 0.93
Differentiating the effects of Cx36 and E-cadherin for proper insulin secretion of MIN6 cells. Exp Cell Res (2004) 0.92
Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types. J Virol (2011) 0.92
Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI. Cell Transplant (2010) 0.92
Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina. J Biol Chem (2003) 0.91
A new optical method for the non-invasive detection of minimal tissue alterations. Phys Med Biol (2002) 0.91
Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. Diabetologia (2005) 0.91
Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proc Natl Acad Sci U S A (2011) 0.90