Published in Proc Natl Acad Sci U S A on July 02, 2004
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity (2007) 8.94
FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73
Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol (2013) 4.72
Checkpoint blockade in cancer immunotherapy. Adv Immunol (2006) 4.09
Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med (2008) 3.70
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood (2010) 3.21
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med (2009) 2.23
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem (2009) 2.18
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med (2005) 1.79
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology (2006) 1.79
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat Immunol (2009) 1.70
Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci U S A (2008) 1.69
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma. J Transl Med (2008) 1.56
CD4+CD25+ regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J Immunol (2005) 1.46
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J Immunol (2006) 1.43
Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther (2012) 1.39
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J Immunol (2009) 1.39
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med (2006) 1.37
Role of the PD-1 pathway in the immune response. Am J Transplant (2012) 1.35
T-cell costimulation and coinhibition in atherosclerosis. Circ Res (2008) 1.32
CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog (2011) 1.26
CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology (2006) 1.20
Aging and human CD4(+) regulatory T cells. Mech Ageing Dev (2009) 1.20
Regulatory T cells and human disease. Clin Dev Immunol (2007) 1.12
NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment. J Immunol (2009) 1.12
Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J Am Soc Nephrol (2008) 1.11
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. Exp Hematol (2007) 1.07
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. Curr Opin Pediatr (2013) 1.06
Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. J Exp Med (2014) 1.05
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood (2009) 1.04
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production. J Transl Med (2013) 1.02
Disruption of TGF-beta signaling prevents the generation of tumor-sensitized regulatory T cells and facilitates therapeutic antitumor immunity. J Immunol (2009) 1.02
CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation. Semin Immunol (2006) 1.02
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog (2011) 1.02
Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol (2010) 1.00
A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J Neuroimmunol (2010) 0.99
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci U S A (2008) 0.99
Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells. Front Immunol (2011) 0.96
Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology (2006) 0.96
CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism. AIDS Res Hum Retroviruses (2010) 0.96
The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol (2012) 0.95
Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice. Biol Blood Marrow Transplant (2011) 0.93
T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med (2008) 0.93
Cytokine network and T cell immunity in atherosclerosis. Semin Immunopathol (2009) 0.90
Immune tolerance and transplantation. Semin Oncol (2012) 0.90
CD4+ regulatory cells as a potential immunotherapy. Philos Trans R Soc Lond B Biol Sci (2005) 0.90
Targeting the B7 family of co-stimulatory molecules: successes and challenges. BioDrugs (2013) 0.89
Regulatory T cells and parasites. J Biomed Biotechnol (2011) 0.88
The blockade of T-cell co-stimulation as a therapeutic stratagem for immunosuppression: Focus on belatacept. Biologics (2007) 0.87
Induction and stability of the anergic phenotype in T cells. Semin Immunol (2013) 0.87
B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol Immunol (2007) 0.86
Autologous MUC1-specific Th1 effector cell immunotherapy induces differential levels of systemic TReg cell subpopulations that result in increased ovarian cancer patient survival. Clin Immunol (2009) 0.86
Emerging Co-signaling Networks in T Cell Immune Regulation. Immune Netw (2013) 0.86
Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells. Clin Exp Immunol (2014) 0.86
Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking. PLoS Pathog (2009) 0.85
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. J Autoimmun (2013) 0.85
Inducing and Administering Tregs to Treat Human Disease. Front Immunol (2016) 0.84
Regulatory T cells: present facts and future hopes. Med Microbiol Immunol (2006) 0.83
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development. Pediatr Rheumatol Online J (2008) 0.83
Levels of interleukin-35 and its relationship with regulatory T-cells in chronic hepatitis B patients. Viral Immunol (2014) 0.82
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms. EMBO Rep (2014) 0.81
Enhancement of suboptimal CD8 cytotoxic T cell effector function in vivo using antigen-specific CD80 defective T cells. J Immunol (2010) 0.81
CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions. Cell Death Dis (2014) 0.81
Requirements for growth and IL-10 expression of highly purified human T regulatory cells. J Clin Immunol (2012) 0.81
Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model. J Transl Med (2013) 0.81
Mechanisms of self-nonself discrimination and possible clinical relevance. Immunotherapy (2009) 0.80
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy. Mol Oncol (2015) 0.79
T-regulatory cells in primary immune deficiencies. Curr Opin Allergy Clin Immunol (2011) 0.79
Harnessing DNA-induced immune responses for improving cancer vaccines. Hum Vaccin Immunother (2012) 0.77
Regulation of antiviral CD8 T-cell responses. Crit Rev Immunol (2013) 0.76
Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro. Can J Vet Res (2017) 0.75
Information-theoretic analysis of the dynamics of an executable biological model. PLoS One (2013) 0.75
"The microbiome and immune regulation after transplantation". Transplantation (2016) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13
CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol (2002) 12.73
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature (1998) 12.07
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18
Natural versus adaptive regulatory T cells. Nat Rev Immunol (2003) 8.74
CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol (2002) 6.94
Regulatory T cells in transplantation tolerance. Nat Rev Immunol (2003) 6.42
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94
Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol (2003) 5.47
The emerging role of CTLA-4 as an immune attenuator. Immunity (1997) 5.35
Control of intestinal inflammation by regulatory T cells. Immunol Rev (2001) 4.73
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science (2002) 4.02
Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol (2004) 3.41
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol (2001) 2.99
B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol (1987) 2.92
Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun (2001) 2.49
The interaction properties of costimulatory molecules revisited. Immunity (2002) 2.43
Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol Rev (2001) 1.99
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A (1992) 1.92
Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol (2001) 1.70
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]. J Immunol (2004) 1.60
CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol (1997) 1.47
CD4(+)CD25(+) T cells facilitate the induction of T cell anergy. J Immunol (2001) 1.31
Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells. Microbes Infect (2001) 1.21
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol (1997) 1.02
Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation. J Immunol (1996) 0.97
Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function. J Immunol (1995) 0.88
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature (2010) 3.68
Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol (2004) 3.41
Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A (2010) 2.88
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity (2008) 2.25
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity (2007) 2.23
Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol (2002) 1.85
T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A (2005) 1.83
Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol (2002) 1.80
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc Natl Acad Sci U S A (2008) 1.77
Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma. Leuk Lymphoma (2011) 1.71
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol (2004) 1.65
Regulatory T cells and autoimmune disease. Immunol Rev (2005) 1.51
Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A (2008) 1.43
CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A (2011) 1.41
Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest (2004) 1.41
Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res (2002) 1.40
T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol (2008) 1.32
Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci U S A (2011) 1.26
Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A (2010) 1.22
The immunoregulatory effects of Qa-1. Immunol Rev (2006) 1.21
Reprogramming after chromosome transfer into mouse blastomeres. Curr Biol (2009) 1.20
CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpful. Cancer Immunol Res (2014) 1.17
Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood (2009) 1.16
Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol (2008) 1.15
TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest (2011) 1.13
Generation and regulation of CD8(+) regulatory T cells. Cell Mol Immunol (2008) 1.11
Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2. Proc Natl Acad Sci U S A (2010) 1.09
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest (2004) 1.08
Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin Immunol (2011) 1.05
Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest (2013) 1.03
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol (2012) 1.01
Bortezomib-resistant nuclear factor κB expression in stem-like cells in mantle cell lymphoma. Exp Hematol (2011) 0.99
miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett (2012) 0.91
Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J Immunol (2010) 0.91
Osteoblastic niche supports the growth of quiescent multiple myeloma cells. Blood (2014) 0.91
The immune response after hypoxia-ischemia in a mouse model of preterm brain injury. J Neuroinflammation (2014) 0.90
Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection. Proc Natl Acad Sci U S A (2013) 0.90
The role of innate immunity in autoimmunity. J Exp Med (2004) 0.89
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med (2002) 0.88
Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum (2004) 0.86
Prospective isolation of clonogenic mantle cell lymphoma-initiating cells. Stem Cell Res (2010) 0.85
Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8⁺ regulatory cells. Eur J Immunol (2012) 0.84
Nuclear translocation of B-cell-specific transcription factor, BACH2, modulates ROS mediated cytotoxic responses in mantle cell lymphoma. PLoS One (2013) 0.84
T cell-dependent and -independent pathways to tissue destruction following herpes simplex virus-1 infection. Eur J Immunol (2002) 0.83
Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. Blood (2012) 0.82
Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity. Cancer Immunol Res (2013) 0.82
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med (2013) 0.82
Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol (2002) 0.81
Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. J Immunol (2007) 0.81
The bridge between dendritic cells and asthma. Nat Med (2007) 0.81
Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses. PLoS One (2011) 0.80
Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells. J Cell Physiol (2004) 0.80
Verapamil synergistically enhances cytotoxicity of bortezomib in mantle cell lymphoma via induction of reactive oxygen species production. Br J Haematol (2012) 0.78
Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol (2002) 0.78
Synergistic anticancer effects of arsenic trioxide with bortezomib in mantle cell lymphoma. Am J Hematol (2012) 0.78
Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A (2004) 0.78
Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A (2010) 0.76
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity (2016) 0.76
Activated mouse CD4(+)Foxp3(-) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity. Cell Res (2012) 0.76
Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice. Proc Natl Acad Sci U S A (2003) 0.75
Corrigendum: The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol (2017) 0.75
Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nat Immunol (2017) 0.75