Published in J Immunol on July 15, 2004
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med (2009) 1.78
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism. J Leukoc Biol (2009) 1.56
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol (2011) 1.45
Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells. Blood (2012) 1.35
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med (2007) 1.30
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med (2007) 1.28
Induction of T cell anergy: integration of environmental cues and infectious tolerance. Curr Opin Immunol (2010) 1.28
Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem (2010) 1.17
Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15
Regulatory T cells overturned: the effectors fight back. Immunology (2009) 1.13
Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest (2010) 1.02
CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation. Mol Ther (2011) 1.00
Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int Arch Allergy Immunol (2007) 0.98
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells. J Immunol (2013) 0.96
Cbl-b in T-cell activation. Semin Immunopathol (2010) 0.88
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A (2010) 0.88
Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. Int Immunol (2011) 0.86
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. Cell Cycle (2014) 0.86
Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis. PLoS One (2013) 0.85
Releasing the brake: targeting Cbl-b to enhance lymphocyte effector functions. Clin Dev Immunol (2012) 0.84
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression. Front Immunol (2016) 0.83
Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy (2010) 0.83
T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber. Int Immunol (2009) 0.83
Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells. J Immunol (2012) 0.81
Modulation of Immune Cell Functions by the E3 Ligase Cbl-b. Front Oncol (2015) 0.81
Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b. J Immunol (2010) 0.80
T-cell tolerance in cancer. Immunotherapy (2013) 0.79
The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells. J Immunol (2009) 0.79
The role of the e3 ligase cbl-B in murine dendritic cells. PLoS One (2013) 0.79
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun (2015) 0.78
ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice. J Autoimmun (2009) 0.77
Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720. Clin Immunol (2015) 0.77
Ubiquitous points of control over regulatory T cells. J Mol Med (Berl) (2014) 0.76
Engineering effective T-cell based antitumor immunity. Oncoimmunology (2013) 0.76
Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation. Front Immunol (2017) 0.75
Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma. Front Immunol (2015) 0.75
T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells. J Immunol (2017) 0.75
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis. Front Immunol (2017) 0.75
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol (2017) 0.75
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition. Oncotarget (2017) 0.75
On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes. J Immunol (2017) 0.75
Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med (2013) 17.53
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med (2015) 14.71
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14
Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med (2012) 8.46
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell (2012) 3.37
Immune modulation in cancer with antibodies. Annu Rev Med (2013) 2.23
A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophys J (2007) 1.81
Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a. Cardiovasc Res (2007) 1.73
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J Immunol (2006) 1.62
The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism. J Leukoc Biol (2009) 1.56
Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types. Clin Cancer Res (2013) 1.51
K+ currents activated by depolarization in cardiac fibroblasts. Biophys J (2005) 1.38
Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms. J Immunol (2007) 1.32
Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med (2014) 1.29
Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies. Cancer Discov (2014) 1.25
Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function. J Immunol (2011) 1.24
Functional properties of K+ currents in adult mouse ventricular myocytes. J Physiol (2004) 1.20
Regulatory role of B cells in a murine model of allergic airway disease. J Immunol (2008) 1.18
Ipilimumab for patients with advanced mucosal melanoma. Oncologist (2013) 1.09
Unique lipids from a common human bacterium represent a new class of Toll-like receptor 2 ligands capable of enhancing autoimmunity. Am J Pathol (2009) 1.03
'Vive la Résistance!'--the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression. Trends Immunol (2007) 1.02
Changes in extracellular K+ concentration modulate contractility of rat and rabbit cardiac myocytes via the inward rectifier K+ current IK1. J Physiol (2004) 1.01
Maternal transmission of resistance to development of allergic airway disease. J Immunol (2007) 0.99
Impaired stretch modulation in potentially lethal cardiac sodium channel mutants. Channels (Austin) (2010) 0.98
Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun (2010) 0.97
Checkpoint modulation in melanoma: an update on ipilimumab and future directions. Curr Oncol Rep (2013) 0.94
Treating human cancers with heat shock protein-peptide complexes: the road ahead. Expert Opin Biol Ther (2009) 0.94
PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One (2010) 0.94
Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circ Res (2013) 0.92
BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. J Neurotrauma (2010) 0.91
PPARgamma regulates retinoic acid-mediated DC induction of Tregs. J Leukoc Biol (2009) 0.91
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy. Cancer J (2011) 0.86
Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. Int Immunol (2011) 0.86
A voltage-dependent K+ current contributes to membrane potential of acutely isolated canine articular chondrocytes. J Physiol (2004) 0.86
Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J (2013) 0.85
Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples. Infect Immun (2011) 0.85
Phosphorylated dihydroceramides from common human bacteria are recovered in human tissues. PLoS One (2011) 0.85
The antitumor immunity of ipilimumab: (T-cell) memories to last a lifetime? Clin Cancer Res (2012) 0.84
Measurement of the membrane potential in small cells using patch clamp methods. Channels (Austin) (2011) 0.84
Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily. J Biol Chem (2003) 0.84
T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber. Int Immunol (2009) 0.83
Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity. J Immunol (2011) 0.83
Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta. J Immunol (2010) 0.83
Health education's role in framing pornography as a public health issue: local and national strategies with international implications. Promot Educ (2008) 0.80
The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells. J Immunol (2009) 0.79
Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med (2012) 0.78
Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe". Immunobiology (2011) 0.76
Improving the therapeutic benefits of ipilimumab. Oncology (Williston Park) (2010) 0.75
The role of chromogranin B in an animal model of multiple sclerosis. Mol Cell Neurosci (2013) 0.75
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2016) 0.75
A phase 2 trial of everolimus and pasireotide long-acting release in patients with metastatic uveal melanoma. Melanoma Res (2016) 0.75