Published in Cell on July 23, 2004
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotechnol (2013) 4.88
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell (2008) 4.06
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol (2012) 3.65
Predicting essential components of signal transduction networks: a dynamic model of guard cell abscisic acid signaling. PLoS Biol (2006) 3.53
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood (2010) 3.41
Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science (2008) 3.38
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A (2005) 3.18
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78
Single cell analysis: the new frontier in 'omics'. Trends Biotechnol (2010) 2.71
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
Web-based analysis and publication of flow cytometry experiments. Curr Protoc Cytom (2010) 2.43
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood (2006) 2.32
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol (2008) 2.30
A chromatic explosion: the development and future of multiparameter flow cytometry. Immunology (2008) 2.17
From single cells to deep phenotypes in cancer. Nat Biotechnol (2012) 2.12
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc Natl Acad Sci U S A (2010) 2.10
Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood (2016) 2.10
Single-cell RNA-seq: advances and future challenges. Nucleic Acids Res (2014) 2.06
Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol (2009) 2.05
Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nat Rev Cancer (2010) 1.97
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood (2006) 1.93
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest (2010) 1.93
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics (2007) 1.82
Dynamic single-cell network profiles in acute myelogenous leukemia are associated with patient response to standard induction therapy. Clin Cancer Res (2010) 1.73
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood (2011) 1.69
Fibrocyte activation in rheumatoid arthritis. Rheumatology (Oxford) (2009) 1.68
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis. Cell (2015) 1.67
Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell (2008) 1.65
Principles and strategies for developing network models in cancer. Cell (2011) 1.65
The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res (2008) 1.58
Navigating the network: signaling cross-talk in hematopoietic cells. Nat Immunol (2009) 1.48
Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma. Cancer Cell (2016) 1.43
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest (2008) 1.41
Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP). PLoS One (2010) 1.36
Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol (2013) 1.35
Targeting an antimicrobial effector function in insect immunity as a pest control strategy. Proc Natl Acad Sci U S A (2009) 1.32
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood (2007) 1.27
A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs). PLoS One (2009) 1.24
Precision medicine for cancer with next-generation functional diagnostics. Nat Rev Cancer (2015) 1.24
Single-cell analysis tools for drug discovery and development. Nat Rev Drug Discov (2015) 1.23
TrAp: a tree approach for fingerprinting subclonal tumor composition. Nucleic Acids Res (2013) 1.23
The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy. Anal Biochem (2007) 1.22
Development of analytical methods for multiplex bio-assay with inductively coupled plasma mass spectrometry. J Anal At Spectrom (2008) 1.21
STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease. Blood (2008) 1.21
Aberrant cytokine signaling in leukemia. Oncogene (2007) 1.20
A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res (2010) 1.20
Highly multiplexed simultaneous detection of RNAs and proteins in single cells. Nat Methods (2016) 1.20
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection. J Virol (2005) 1.19
Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions. PLoS One (2008) 1.19
Cancer metastasis networks and the prediction of progression patterns. Br J Cancer (2009) 1.17
A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.17
A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice. Exp Hematol (2011) 1.17
The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles. Genome Biol (2005) 1.17
Inferring clonal composition from multiple sections of a breast cancer. PLoS Comput Biol (2014) 1.17
Molecular signatures from omics data: from chaos to consensus. Biotechnol J (2012) 1.17
High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Anal Chem (2013) 1.16
HIV-induced changes in T cell signaling pathways. J Immunol (2008) 1.16
Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy. Clin Cancer Res (2011) 1.14
New tools for classification and monitoring of autoimmune diseases. Nat Rev Rheumatol (2012) 1.13
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood (2013) 1.12
The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol (2009) 1.11
Intercellular transfer of oncogenic H-Ras at the immunological synapse. PLoS One (2007) 1.11
Single-cell network profiling of peripheral blood mononuclear cells from healthy donors reveals age- and race-associated differences in immune signaling pathway activation. J Immunol (2012) 1.10
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol (2010) 1.10
Quantitative phosphoproteomic analysis of signaling network dynamics. Curr Opin Biotechnol (2008) 1.10
LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol Cancer (2007) 1.10
The dynamic control of signal transduction networks in cancer cells. Nat Rev Cancer (2015) 1.09
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma. PLoS One (2010) 1.09
Responsiveness of T cells to interleukin-7 is associated with higher CD4+ T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression. J Infect Dis (2009) 1.08
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia. PLoS One (2010) 1.08
Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts. Cytometry B Clin Cytom (2012) 1.08
Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data. Methods (2015) 1.06
Single-cell protein analysis. Curr Opin Biotechnol (2011) 1.05
Deciphering signaling outcomes from a system of complex networks. Sci Signal (2009) 1.05
Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening. Curr Opin Pharmacol (2007) 1.04
Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.04
Using network biology to bridge pharmacokinetics and pharmacodynamics in oncology. CPT Pharmacometrics Syst Pharmacol (2013) 1.03
Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Mol Syst Biol (2007) 1.02
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A (2010) 1.01
Poly(I:C) and lipopolysaccharide innate sensing functions of circulating human myeloid dendritic cells are affected in vivo in hepatitis C virus-infected patients. J Virol (2007) 1.00
Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment. Acta Pharmacol Sin (2015) 0.99
Models of signalling networks - what cell biologists can gain from them and give to them. J Cell Sci (2013) 0.99
Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry. Cytometry A (2010) 0.99
Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells. Mol Immunol (2009) 0.99
Systematic quantitative characterization of cellular responses induced by multiple signals. BMC Syst Biol (2011) 0.99
Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus. PLoS One (2009) 0.98
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit. Blood (2010) 0.97
Microfluidic concentration-enhanced cellular kinase activity assay. J Am Chem Soc (2009) 0.97
Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells. BMC Genomics (2008) 0.97
FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood (2012) 0.97
Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition. Proc Natl Acad Sci U S A (2009) 0.96
Complexity and challenges in defining myeloid-derived suppressor cells. Cytometry B Clin Cytom (2014) 0.95
Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
Computational solutions to large-scale data management and analysis. Nat Rev Genet (2010) 6.58
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol (2011) 5.46
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity (2012) 5.26
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods (2006) 5.25
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotechnol (2013) 4.88
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A (2003) 4.45
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell (2008) 4.06
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol (2012) 3.65
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood (2010) 3.41
Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat Rev Cancer (2006) 3.24
A deep profiler's guide to cytometry. Trends Immunol (2012) 3.14
Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol (2004) 2.69
Normalization of mass cytometry data with bead standards. Cytometry A (2013) 2.63
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol (2003) 2.58
High-content single-cell drug screening with phosphospecific flow cytometry. Nat Chem Biol (2007) 2.54
Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry. Nat Biotechnol (2002) 2.43
Web-based analysis and publication of flow cytometry experiments. Curr Protoc Cytom (2010) 2.43
Chemical combination effects predict connectivity in biological systems. Mol Syst Biol (2007) 2.42
Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood (2006) 2.32
From single cells to deep phenotypes in cancer. Nat Biotechnol (2012) 2.12
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc Natl Acad Sci U S A (2010) 2.10
Chemical labeling strategies for cell biology. Nat Methods (2006) 2.05
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity (2010) 2.05
Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology (2006) 2.03
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov (2013) 1.93
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood (2006) 1.93
Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J Immunol (2005) 1.93
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia. Blood (2011) 1.74
Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol (2006) 1.72
Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML. Cell Stem Cell (2012) 1.71
A platinum-based covalent viability reagent for single-cell mass cytometry. Cytometry A (2012) 1.69
Fibrocyte activation in rheumatoid arthritis. Rheumatology (Oxford) (2009) 1.68
Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J Immunol (2005) 1.65
The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res (2008) 1.58
Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence. Nat Methods (2006) 1.40
Flow cytometric analysis of kinase signaling cascades. Methods Mol Biol (2004) 1.38
Single-cell phospho-protein analysis by flow cytometry. Curr Protoc Immunol (2007) 1.38
Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level. Immunol Rev (2006) 1.38
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A (2010) 1.36
Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol (2013) 1.35
In vivo targeting of organic calcium sensors via genetically selected peptides. Chem Biol (2004) 1.35
Single-cell mass cytometry adapted to measurements of the cell cycle. Cytometry A (2012) 1.33
Activation of the PKB/AKT pathway by ICAM-2. Immunity (2002) 1.31
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood (2007) 1.27
Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS One (2008) 1.27
A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs). PLoS One (2009) 1.24
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Blood (2006) 1.23
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. Neuro Oncol (2011) 1.22
A general approach for chemical labeling and rapid, spatially controlled protein inactivation. Proc Natl Acad Sci U S A (2004) 1.21
Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A (2013) 1.19
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection. J Virol (2005) 1.19
Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining. Cytometry A (2014) 1.18
Increasing rates of reaction: microwave-assisted organic synthesis for combinatorial chemistry. J Comb Chem (2002) 1.18
Fluorescent cell barcoding for multiplex flow cytometry. Curr Protoc Cytom (2011) 1.16
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. J Virol (2006) 1.15
Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Mol Biol Cell (2003) 1.14
The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol (2009) 1.11
An 8.9 Mb 19p13 duplication associated with precocious puberty and a sporadic 3.9 Mb 2q23.3q24.1 deletion containing NR4A2 in mentally retarded members of a family with an intrachromosomal 19p-into-19q between-arm insertion. Eur J Hum Genet (2009) 1.11
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol (2010) 1.10
LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol Cancer (2007) 1.10
Copy-number gains of HUWE1 due to replication- and recombination-based rearrangements. Am J Hum Genet (2012) 1.09
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia. PLoS One (2010) 1.08
Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples. Methods Mol Biol (2011) 1.07
Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A (2010) 1.05
Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications. J Biomed Biotechnol (2011) 1.05
CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data. Bioinformatics (2012) 1.04
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer. PLoS One (2011) 1.03
Phospho-specific flow cytometry: intersection of immunology and biochemistry at the single-cell level. Curr Opin Mol Ther (2006) 1.00
Nuclear factor-kappaB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia. Crit Rev Oncog (2009) 0.99
Cloud and heterogeneous computing solutions exist today for the emerging big data problems in biology. Nat Rev Genet (2011) 0.99
Electron microscopy localization and characterization of functionalized composite organic-inorganic SERS nanoparticles on leukemia cells. Ultramicroscopy (2008) 0.99
Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry. Cytometry A (2010) 0.99
Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities. Haematologica (2003) 0.99
Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival. Br J Haematol (2008) 0.99
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells. Blood (2004) 0.99
Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus. PLoS One (2009) 0.98
Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene (2005) 0.98