Cell cycle regulation of central spindle assembly.

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov (2010) 3.84

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell (2005) 3.04

The 3Ms of central spindle assembly: microtubules, motors and MAPs. Nat Rev Mol Cell Biol (2009) 2.88

Molecular control of animal cell cytokinesis. Nat Cell Biol (2012) 2.45

Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33

Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc Natl Acad Sci U S A (2004) 2.29

The reversibility of mitotic exit in vertebrate cells. Nature (2006) 2.16

Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature (2005) 2.09

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol (2009) 2.02

MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc Natl Acad Sci U S A (2005) 2.00

Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell (2005) 1.89

Cdk-counteracting phosphatases unlock mitotic exit. Curr Opin Cell Biol (2008) 1.80

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78

Spatiotemporal control of spindle midzone formation by PRC1 in human cells. Proc Natl Acad Sci U S A (2006) 1.73

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68

The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. Mol Biol Cell (2005) 1.66

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells. Genome Biol (2008) 1.46

Rho-kinase controls cell shape changes during cytokinesis. Curr Biol (2006) 1.42

Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol (2005) 1.40

Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol (2010) 1.36

Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation. Dev Cell (2009) 1.35

Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex. Mol Biol Cell (2007) 1.33

Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase. J Cell Biol (2010) 1.32

Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 1.30

Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol Biol Cell (2005) 1.29

Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One (2008) 1.28

Cancer biomarker discovery: the entropic hallmark. PLoS One (2010) 1.26

Centralspindlin: at the heart of cytokinesis. Cytoskeleton (Hoboken) (2012) 1.24

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell (2013) 1.23

Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody. Curr Biol (2009) 1.23

Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. Biochem J (2005) 1.20

An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning. J Cell Biol (2008) 1.18

Cytokinesis microtubule organisers at a glance. J Cell Sci (2012) 1.17

A cell cycle timer for asymmetric spindle positioning. PLoS Biol (2009) 1.16

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol (2013) 1.13

Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex. PLoS One (2007) 1.12

The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Mol Biol Cell (2005) 1.11

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase. J Cell Biol (2013) 1.09

Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol (2009) 1.08

Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06

Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis. Cytoskeleton (Hoboken) (2011) 1.05

Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell (2012) 1.05

Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease. Neuron (2015) 1.03

An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis. PLoS One (2012) 1.01

A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis. Mol Cell Biol (2012) 1.00

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00

CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. Mol Cell Biol (2008) 1.00

Phospho-regulation of kinesin-5 during anaphase spindle elongation. J Cell Sci (2011) 1.00

The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton. Mol Biol Cell (2007) 0.99

Cytokinesis in animal cells. Cold Spring Harb Perspect Biol (2015) 0.99

Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis. Biochem Soc Trans (2008) 0.99

Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants. Proc Natl Acad Sci U S A (2011) 0.97

Mad2 inhibits the mitotic kinesin MKlp2. J Cell Biol (2010) 0.97

Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A. J Cell Biol (2009) 0.94

The CDC14A phosphatase regulates oocyte maturation in mouse. Cell Cycle (2009) 0.93

KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle. J Cell Biol (2014) 0.91

Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. J Biol Chem (2009) 0.91

CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation. PLoS Biol (2015) 0.91

APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis. PLoS One (2011) 0.89

A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in Dictyostelium. Proc Natl Acad Sci U S A (2004) 0.89

B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast. PLoS Genet (2010) 0.89

Cell division: timing the machine. Nature (2004) 0.87

Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex. J Biol Chem (2010) 0.86

Cell cycle regulation of Rho signaling pathways. Cell Cycle (2012) 0.85

The molecular basis for kinesin functional specificity during mitosis. Cytoskeleton (Hoboken) (2013) 0.84

Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone. Semin Cell Dev Biol (2010) 0.83

A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments. Curr Biol (2012) 0.81

A mitotic kinesin-6, Pav-KLP, mediates interdependent cortical reorganization and spindle dynamics in Drosophila embryos. J Cell Sci (2010) 0.81

Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci (2014) 0.80

Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell Signal (2014) 0.80

Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain. Sci Rep (2016) 0.79

Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem (2013) 0.79

Late mitotic functions of Aurora kinases. Chromosoma (2016) 0.78

Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor. Nat Commun (2016) 0.77

Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit. J Biol Chem (2013) 0.77

The role of FIP3-dependent endosome transport during cytokinesis. Commun Integr Biol (2008) 0.77

Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites. PLoS One (2015) 0.76

What is your assay for sister-chromatid cohesion? EMBO J (2007) 0.76

Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. Exp Mol Med (2009) 0.76

Live birth rate and number of blastomeres on day 2 transfer. J Assist Reprod Genet (2016) 0.75

Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis. PLoS Genet (2017) 0.75

Cell division: the need for speed. Curr Biol (2009) 0.75

Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61

Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol (2004) 7.22

The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol (2005) 5.84

Plk4-induced centriole biogenesis in human cells. Dev Cell (2007) 5.68

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev Cell (2002) 5.52

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science (2002) 4.94

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54

Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol (2003) 4.31

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98

Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol (2007) 3.88

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80

An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol (2005) 3.74

Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene (2005) 3.64

Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49

HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol (2006) 3.21

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol (2003) 3.12

Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev (2004) 2.96

Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev (2007) 2.92

Cytokinesis: welcome to the Rho zone. Trends Cell Biol (2005) 2.87

The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Curr Biol (2002) 2.86

Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell (2007) 2.72

Control of centriole length by CPAP and CP110. Curr Biol (2009) 2.67

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63

TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods (2012) 2.59

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat Cell Biol (2007) 2.54

Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis. Curr Biol (2007) 2.49

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44

Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis. Curr Biol (2007) 2.44

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J (2002) 2.41

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol (2005) 2.41

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell (2005) 2.40

Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO Rep (2002) 2.40

Rootletin forms centriole-associated filaments and functions in centrosome cohesion. J Cell Biol (2005) 2.38

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38

Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells. Curr Biol (2004) 2.37

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31

Proteome analysis of the human mitotic spindle. Mol Cell Proteomics (2004) 2.31

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells (2002) 2.28

Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation. Nature (2005) 2.26

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science (2013) 2.25

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open (2012) 2.23

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell (2003) 2.18

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell (2004) 2.17

GTP binding induces filament assembly of a recombinant septin. Curr Biol (2002) 2.16

Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J (2006) 2.14

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Mol Biol Cell (2005) 2.09

KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol (2006) 2.06

Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation. Dev Cell (2003) 2.05

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol (2009) 2.02

Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol (2005) 2.00

Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell (2006) 1.94

The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91

Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Mol Cell (2003) 1.85

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma (2007) 1.78

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci (2007) 1.78

Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J (2009) 1.76

Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. J Cell Sci (2010) 1.74

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. J Cell Sci (2002) 1.73

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J Cell Biol (2009) 1.64

Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. J Biol Chem (2002) 1.63

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62

Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. J Cell Sci (2006) 1.62

Cell-cycle-regulated expression of STIL controls centriole number in human cells. J Cell Sci (2012) 1.60

The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biol (2010) 1.60

Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma (2008) 1.60

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J Cell Biol (2007) 1.59

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton (2004) 1.59

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev (2005) 1.57

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. J Cell Sci (2013) 1.55

Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53

CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. J Cell Biol (2003) 1.52

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem (2002) 1.47

A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol Biol Cell (2005) 1.45

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1. J Cell Sci (2010) 1.42

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J (2008) 1.38

Centrosome-associated NDR kinase regulates centrosome duplication. Mol Cell (2007) 1.37

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. J Cell Biol (2005) 1.34

Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs. Chromosoma (2009) 1.33

Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene (2003) 1.33

Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex. Mol Biol Cell (2007) 1.33

Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. Chromosoma (2004) 1.30

Sgt1 is required for human kinetochore assembly. EMBO Rep (2004) 1.30

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division. J Cell Sci (2010) 1.28

Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Genes Dev (2003) 1.27

Cytostatic factor: an activity that puts the cell cycle on hold. J Cell Sci (2006) 1.27

Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases. Mol Cell Biol (2005) 1.26

Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. J Cell Sci (2005) 1.25

Centralspindlin: at the heart of cytokinesis. Cytoskeleton (Hoboken) (2012) 1.24

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev (2012) 1.23

Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody. Curr Biol (2009) 1.23

The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol (2002) 1.19