Published in Anal Chem on August 01, 2004
UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1. PLoS One (2015) 1.40
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems. Proc Natl Acad Sci U S A (2010) 1.03
Electrospray ionization mass spectrometry: a technique to access the information beyond the molecular weight of the analyte. Int J Anal Chem (2011) 0.97
Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem (2009) 0.82
Estrogen receptor-ligand complexes measured by chip-based nanoelectrospray mass spectrometry: an approach for the screening of endocrine disruptors. Protein Sci (2007) 0.81
Mass spectrometric analysis of protein-ligand interactions. Biophys Physicobiol (2016) 0.81
Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. J Mass Spectrom (2005) 0.80
Optimization of Electrospray Ionization by Statistical Design of Experiments and Response Surface Methodology: Protein-Ligand Equilibrium Dissociation Constant Determinations. J Am Soc Mass Spectrom (2016) 0.75
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Shorthand notation for lipid structures derived from mass spectrometry. J Lipid Res (2013) 1.80
Cholestenoic acids regulate motor neuron survival via liver X receptors. J Clin Invest (2014) 1.55
Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics (2004) 1.46
Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells. Mol Biochem Parasitol (2008) 1.31
Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. EMBO J (2003) 1.31
Identification of immunoreactive proteins during acute human giardiasis. J Infect Dis (2003) 1.24
Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes. Proc Natl Acad Sci U S A (2004) 1.23
Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain? J Biol Chem (2009) 1.23
High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1. Biochim Biophys Acta (2004) 1.14
Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. J Lipid Res (2007) 1.11
Characterisation of alpha-1 giardin: an immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity. Int J Parasitol (2003) 1.11
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol (2012) 1.09
Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry. Eur J Biochem (2003) 1.08
DMSO-related effects in protein characterization. J Biomol Screen (2006) 1.06
Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry. Anal Chem (2003) 1.06
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. J Proteome Res (2008) 1.04
Antibacterial peptides in stimulated human granulocytes: characterization of ubiquitinated histone H1A. Eur J Biochem (2002) 1.02
Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two-way data analysis. Anal Chem (2003) 0.98
Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem Biophys Res Commun (2007) 0.98
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. J Lipid Res (2012) 0.97
Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling. Mol Cell Proteomics (2007) 0.96
Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Mol Biosyst (2009) 0.96
Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chem Phys Lipids (2011) 0.96
Influence of droplet size, capillary-cone distance and selected instrumental parameters for the analysis of noncovalent protein-ligand complexes by nano-electrospray ionization mass spectrometry. J Mass Spectrom (2004) 0.95
Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase. Appl Environ Microbiol (2012) 0.94
Structural characterization of the tetrameric form of the major cat allergen Fel d 1. J Mol Biol (2007) 0.93
Metabolic fingerprinting of rat urine by LC/MS Part 1. Analysis by hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.93
Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B). Bioorg Med Chem Lett (2004) 0.91
Metabolic fingerprinting of rat urine by LC/MS Part 2. Data pretreatment methods for handling of complex data. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.91
An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences. Anal Biochem (2007) 0.90
On-column electrochemical reactions accompanying the electrospray process. Anal Chem (2003) 0.90
Liver disease in infancy caused by oxysterol 7 α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid. J Inherit Metab Dis (2014) 0.89
Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry. J Proteome Res (2009) 0.88
Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry. J Biol Chem (2004) 0.87
Folding into a beta-hairpin can prevent amyloid fibril formation. Biochemistry (2004) 0.87
Matrix-assisted laser desorption/ionization high-energy collision-induced dissociation of steroids: analysis of oxysterols in rat brain. Anal Chem (2006) 0.87
Capillary liquid chromatography/electrospray mass spectrometry for analysis of steroid sulfates in biological samples. Anal Chem (2003) 0.86
Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes. Anal Chem (2003) 0.86
The antimicrobial peptide LL-37 binds to the human plasma protein apolipoprotein A-I. Rapid Commun Mass Spectrom (2004) 0.85
Design and synthesis of potent and selective BACE-1 inhibitors. J Med Chem (2010) 0.85
Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione. Arch Biochem Biophys (2009) 0.84
Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie (2006) 0.84
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors. Antimicrob Agents Chemother (2008) 0.84
Electrospray tandem mass spectrometry of intact beta-chain hemoglobin variants. Anal Chem (2002) 0.83
Characterization of the elusive disulfide bridge forming human Hb variant: Hb Ta-Li beta83 (EF7)Gly --> Cys by electrospray mass spectrometry. J Am Soc Mass Spectrom (2002) 0.83
Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development. Pharmacol Rep (2006) 0.83
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Biochem Pharmacol (2013) 0.82
Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics (2008) 0.82
Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry. Steroids (2005) 0.81
Multivariate approaches for efficient detection of potential metabolites from liquid chromatography/mass spectrometry data. Rapid Commun Mass Spectrom (2004) 0.81
Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. Biochem Pharmacol (2013) 0.81
The mammalian alcohol dehydrogenases interact in several metabolic pathways. Chem Biol Interact (2003) 0.80
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity. Bioorg Med Chem (2008) 0.80
Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. J Mass Spectrom (2005) 0.80
Electrospray mass spectrometry for the direct accurate mass measurement of ligands in complex with the retinoid X receptor alpha ligand binding domain. J Am Soc Mass Spectrom (2005) 0.80
The development of a continuous isothermal titration calorimetric method for equilibrium studies. Anal Biochem (2004) 0.79
Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction. Rapid Commun Mass Spectrom (2005) 0.79
Activation of erythropoietin receptor through a novel extracellular binding site. Endocrinology (2002) 0.79
Revised sample preparation for the analysis of oxysterols by enzyme-assisted derivatisation for sterol analysis (EADSA). Anal Bioanal Chem (2015) 0.78
On-line microdialysis for enhanced resolution and sensitivity during electrospray mass spectrometry of non-covalent complexes and competitive binding studies. Rapid Commun Mass Spectrom (2002) 0.78
Alkaline hydrolysis of oxaliplatin--isolation and identification of the oxalato monodentate intermediate. J Pharm Sci (2002) 0.78
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents. Bioorg Med Chem Lett (2010) 0.78
Hydrogen/deuterium exchange and aggregation of a polyvaline and a polyleucine alpha-helix investigated by matrix-assisted laser desorption ionization mass spectrometry. Mol Cell Proteomics (2002) 0.78
Investigation of multiple binding sites on ribonuclease A using nano-electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom (2005) 0.77
Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer. Rapid Commun Mass Spectrom (2002) 0.77
Automated nano-electrospray mass spectrometry for protein-ligand screening by noncovalent interaction applied to human H-FABP and A-FABP. J Biomol Screen (2003) 0.77
Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. Lipids (2010) 0.76
Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain. Neurochem Int (2007) 0.76
Hydrolysis of the amyloid beta-peptide (A beta) 1-40 between Asp23-Val24 produces non-aggregating fragments. An electrospray mass spectrometric study. J Mass Spectrom (2005) 0.76
Detecting oxysterols in the human circulation. Nat Immunol (2011) 0.76
Shotgun cholanomics of ileal fluid. Biochimie (2012) 0.75
Metabolism of 2-substituted quinolines with antileishmanial activity studied in vitro with liver microsomes, hepatocytes and recombinantly expressed enzymes analyzed by LC/MS. Toxicology (2007) 0.75
Haemoglobin Södertälje (beta118 Phe-->Val): a new mutation in human haemoglobin identified by electrospray ionisation mass spectrometry. Rapid Commun Mass Spectrom (2006) 0.75
A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.75
Development of a two-dimensional liquid chromatography system for isolation of drug metabolites. J Pharm Biomed Anal (2009) 0.75
Identification of N-terminal acetylation in Hb Raleigh (beta1Val-->Ac-Ala) by electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom (2002) 0.75
Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents. Rapid Commun Mass Spectrom (2003) 0.75
Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. Bioorg Med Chem (2013) 0.75
Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry. Rapid Commun Mass Spectrom (2011) 0.75
Identification of variant forms of the neuroendocrine peptide galanin. Rapid Commun Mass Spectrom (2004) 0.75
Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore-Boston-Washington from the blood of a heterozygote. J Mass Spectrom (2004) 0.75
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. J Med Chem (2009) 0.75
Unravelling new pathways of sterol metabolism: lessons learned from in-born errors and cancer. Curr Opin Clin Nutr Metab Care (2017) 0.75