Published in J Neuroinflammation on July 01, 2004
Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice. Am J Pathol (2006) 1.38
TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation (2010) 1.35
Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol (2012) 1.21
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacol Rev (2013) 1.01
Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res (2013) 0.97
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol (2014) 0.97
Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia (2012) 0.95
Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia (2014) 0.93
Rodent models of neuroinflammation for Alzheimer's disease. J Neuroinflammation (2015) 0.87
TGFβ Contributes to the Anti-inflammatory Effects of Tauroursodeoxycholic Acid on an Animal Model of Acute Neuroinflammation. Mol Neurobiol (2016) 0.80
Nutritional and Nanotechnological Modulators of Microglia. Front Immunol (2016) 0.75
Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability. Eur J Hum Genet (2015) 0.75
Neuroprotective effects of G-CSF administration in microglia-mediated reactive T cell activation in vitro. Immunol Res (2017) 0.75
Age-Dependent Effects of ALK5 Inhibition and Mechanism of Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury. Dev Neurosci (2017) 0.75
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science (1996) 19.72
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci (2000) 9.85
Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet (1994) 6.50
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci U S A (1987) 6.43
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci U S A (1981) 5.89
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J (2002) 5.44
Translating cell biology into therapeutic advances in Alzheimer's disease. Nature (1999) 5.42
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci (2004) 5.36
Inflammation in neurodegenerative disease--a double-edged sword. Neuron (2002) 4.95
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med (2003) 4.77
Cerebral amyloid angiopathy. A critical review. Stroke (1987) 4.56
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development (1995) 4.05
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med (2001) 3.84
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell (2003) 3.80
Molecular profile of reactive astrocytes--implications for their role in neurologic disease. Neuroscience (1993) 3.51
TGF-beta is a critical mediator of acute lung injury. J Clin Invest (2001) 3.29
Transforming growth factor beta (TGF-beta) in inflammation: a cause and a cure. J Clin Immunol (1992) 3.13
Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev (1997) 3.11
Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation. Neuron (2002) 2.87
Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37
Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation (1998) 2.29
TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax (2000) 2.14
The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology (1993) 2.12
Role of transforming growth factor-beta in long-term synaptic facilitation in Aplysia. Science (1997) 2.05
Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron (2003) 2.02
TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int (1997) 2.01
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature (1997) 1.99
Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol (1998) 1.92
Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage. Proc Natl Acad Sci U S A (2000) 1.86
TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell (2003) 1.84
An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron (1994) 1.77
Transforming growth factor beta signal transduction. J Leukoc Biol (2002) 1.76
Neuropathological changes caused by hydrocephalus. Acta Neuropathol (1993) 1.73
Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol (1992) 1.64
Transforming growth factor-betas in neurodegenerative disease. Prog Neurobiol (1998) 1.59
Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol Aging (2002) 1.56
Alzheimer's disease after remote head injury: an incidence study. J Neurol Neurosurg Psychiatry (1997) 1.53
The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. Am J Hum Genet (1997) 1.53
Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. Stroke (1996) 1.51
Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Nat Genet (1997) 1.51
Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci (2002) 1.49
Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol (1995) 1.47
Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res (1993) 1.45
Increased plasma TGF-beta1 in patients with amyotrophic lateral sclerosis. Acta Neurol Scand (2002) 1.43
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol (2000) 1.39
Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis. Ann Neurol (1994) 1.33
Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy. Eur J Neurosci (2000) 1.32
TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms. Stroke (1996) 1.29
Transforming growth factor beta1 alters synapsin distribution and modulates synaptic depression in Aplysia. J Neurosci (2002) 1.25
Cerebral vascular abnormalities in a murine model of hereditary hemorrhagic telangiectasia. Stroke (2003) 1.25
Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. Proc Natl Acad Sci U S A (1994) 1.24
Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J Biol Chem (2003) 1.17
Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice . J Neuroimmunol (1997) 1.17
Neuronal, astroglial and microglial cytokine expression after an excitotoxic lesion in the immature rat brain. Eur J Neurosci (2000) 1.16
Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport (1993) 1.16
Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo. J Cereb Blood Flow Metab (2003) 1.16
Elevated plasma levels of transforming growth factor-beta 1 in NIDDM. Diabetes Care (1996) 1.16
Extracellular matrix. 2: Role of extracellular matrix molecules and their receptors in the nervous system. FASEB J (1993) 1.12
Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain. Am J Pathol (2002) 1.11
Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ss1 expression. Stroke (2001) 1.11
Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral injury. Brain Res (1992) 1.11
A beta amyloidogenesis: unique, or variation on a systemic theme? Crit Rev Biochem Mol Biol (1997) 1.11
Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease. Brain Res Mol Brain Res (1996) 1.08
Inflammatory cytokine cascade released by leukocytes in cerebrospinal fluid after subarachnoid hemorrhage. Neurol Res (2001) 1.08
Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathol Appl Neurobiol (2002) 1.04
TGF-betas and their roles in the regulation of neuron survival. Adv Exp Med Biol (2002) 1.03
Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia. Arch Neurol (2000) 1.03
Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study. Ultrastruct Pathol (1994) 1.02
Regulation of astrocyte GFAP expression by TGF-beta1 and FGF-2. Glia (1998) 1.02
Expression of transforming growth factor (TGF)-beta1, -beta2, and -beta3 isoforms and TGF-beta type I and type II receptors in multiple sclerosis lesions and human adult astrocyte cultures. J Neuropathol Exp Neurol (1999) 1.00
Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease. Brain Res (1990) 1.00
Transforming growth factor-beta1: a possible signal molecule for posthemorrhagic hydrocephalus? Pediatr Res (1999) 0.99
Laminin and the mechanism of neuronal outgrowth. Brain Res Brain Res Rev (1997) 0.98
Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis. Clin Exp Immunol (1997) 0.97
Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads. Biochem Biophys Res Commun (2002) 0.96
TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration. Exp Neurol (1993) 0.95
Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus. J Neuropathol Exp Neurol (1995) 0.94
TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid. Exp Neurol (1996) 0.94
Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia. Brain Res Mol Brain Res (1996) 0.94
Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release. J Infect Dis (2003) 0.94
Astroglial permissivity for neuritic outgrowth in neuron-astrocyte cocultures depends on regulation of laminin bioavailability. Glia (2002) 0.94
Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage: titers derived from exogenous and endogenous sources. J Cereb Blood Flow Metab (2001) 0.94
Differential expression of TGF-beta 1, 2 and 3 isotypes in Alzheimer's disease: a comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains. J Neuropathol Exp Neurol (1995) 0.94
Transforming growth factor-beta 1 reduces infarct size after experimental cerebral ischemia in a rabbit model. Stroke (1993) 0.94
Chemokine upregulation follows cytokine expression in chronic relapsing experimental autoimmune encephalomyelitis. Scand J Immunol (2003) 0.93
Retrograde regulation in the CNS; neuron-specific interpretations of TGF-beta signaling. Neuron (2004) 0.93
Transforming growth factor-beta 1 exhibits delayed gene expression following focal cerebral ischemia. Brain Res Bull (1995) 0.93
Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor-beta 1. J Neuroimmunol (1994) 0.93
Transforming growth factor beta 1 and fibronectin messenger RNA in rat brain: responses to injury and cell-type localization. Neuroscience (1993) 0.93
Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course. Am J Pathol (1996) 0.93
Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia. Acta Neuropathol (1993) 0.91
Transforming growth factor-beta 1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease. Neurosci Lett (1995) 0.90
Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brain. Brain Res Mol Brain Res (1992) 0.90
Transforming growth factor-Beta 1 (tgf-Beta 1) in patients with amyotrophic lateral sclerosis. Cytokine (2002) 0.89
Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res (1995) 0.86
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med (2007) 6.80
The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature (2011) 6.71
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Identification of a central role for complement in osteoarthritis. Nat Med (2011) 3.11
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci (2009) 2.82
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A (2003) 2.24
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci (2004) 2.07
Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron (2003) 2.02
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest (2006) 1.87
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest (2007) 1.78
TDP-43 frontotemporal lobar degeneration and autoimmune disease. J Neurol Neurosurg Psychiatry (2013) 1.74
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. Proc Natl Acad Sci U S A (2006) 1.47
Highly sensitive and specific bioassay for measuring bioactive TGF-beta. BMC Cell Biol (2006) 1.42
The immunology of neurodegeneration. J Clin Invest (2012) 1.41
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol (2005) 1.39
Angiotensin II sustains brain inflammation in mice via TGF-beta. J Clin Invest (2010) 1.39
Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice. Am J Pathol (2006) 1.38
Neural progenitor cells regulate microglia functions and activity. Nat Neurosci (2012) 1.34
Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol (2007) 1.32
The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci (2009) 1.31
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med (2013) 1.27
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron (2013) 1.26
Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J Neurosci (2011) 1.23
The role of inflammation in age-related disease. Aging (Albany NY) (2013) 1.22
Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One (2010) 1.22
Collagen VI protects neurons against Abeta toxicity. Nat Neurosci (2009) 1.19
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav (2012) 1.15
Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease. J Neuroinflammation (2008) 1.13
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem (2003) 1.08
Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathol (2004) 1.08
Killing pain, killing neurons? Nat Med (2005) 0.99
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol (2010) 0.98
A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Curr Alzheimer Res (2006) 0.98
Immune cells may fend off Alzheimer disease. Nat Med (2007) 0.97
Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol (2007) 0.96
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol (2006) 0.96
Beclin 1 complex in autophagy and Alzheimer disease. Arch Neurol (2010) 0.95
Autophagy in dementias. Brain Pathol (2012) 0.95
Systemic and acquired immune responses in Alzheimer's disease. Int Rev Neurobiol (2007) 0.95
Blood protein signature for the early diagnosis of Alzheimer disease. Arch Neurol (2008) 0.95
Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging (2013) 0.92
Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation. J Exp Med (2014) 0.92
Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome. Mol Cell Proteomics (2011) 0.92
Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients. Am J Pathol (2012) 0.92
The circulatory systemic environment as a modulator of neurogenesis and brain aging. Autoimmun Rev (2012) 0.90
Increased T cell recruitment to the CNS after amyloid beta 1-42 immunization in Alzheimer's mice overproducing transforming growth factor-beta 1. J Neurosci (2006) 0.89
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice. J Neuroinflammation (2012) 0.88
Microglia--a wrench in the running wheel? Neuron (2008) 0.87
APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory. Neurology (2014) 0.86
Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities. Neurobiol Dis (2005) 0.86
Live imaging of Smad2/3 signaling in mouse skin wound healing. Wound Repair Regen (2007) 0.83
Chronic over-expression of TGFβ1 alters hippocampal structure and causes learning deficits. Hippocampus (2013) 0.81
Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging (2011) 0.80
Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression. J Alzheimers Dis (2013) 0.80
Small molecule tgf-beta mimetics as potential neuroprotective factors. Curr Alzheimer Res (2005) 0.78
Bioluminescence analysis of Smad-dependent TGF-beta signaling in live mice. Methods Mol Biol (2009) 0.78
A revival of parabiosis in biomedical research. Swiss Med Wkly (2014) 0.78
Molecular and functional dissection of TGF-beta1-induced cerebrovascular abnormalities in transgenic mice. Ann N Y Acad Sci (2002) 0.78
In vitro analysis of transforming growth factor-beta1 inhibition in novel transgenic SBE-luciferase mice. Ann Plast Surg (2007) 0.77
Sorting through the roles of beclin 1 in microglia and neurodegeneration. J Neuroimmune Pharmacol (2014) 0.77
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. J Neurochem (2009) 0.77
Targeting autophagy for disease therapy. Nat Biotechnol (2013) 0.76
Workshop summary: roles of the TNF family in neuronal development, function and pathology. Adv Exp Med Biol (2011) 0.75
The 1st International standard for transforming growth factor-β3 (TGF-β3). J Immunol Methods (2012) 0.75