Published in Plant Physiol on August 06, 2004
A modular approach for facile biosynthesis of labdane-related diterpenes. J Am Chem Soc (2007) 2.13
Gramene 2013: comparative plant genomics resources. Nucleic Acids Res (2013) 2.08
Two rings in them all: the labdane-related diterpenoids. Nat Prod Rep (2010) 2.07
Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions. Plant Physiol (2004) 1.88
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice. Plant Cell (2009) 1.73
Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. BMC Plant Biol (2010) 1.71
Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res (2014) 1.58
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc Natl Acad Sci U S A (2013) 1.44
Regulation of metabolic gene clusters in Arabidopsis thaliana. New Phytol (2014) 1.44
CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. Plant J (2010) 1.39
A convenient method for simultaneous quantification of multiple phytohormones and metabolites: application in study of rice-bacterium interaction. Plant Methods (2012) 1.36
Operons. Cell Mol Life Sci (2009) 1.33
Terpene Specialized Metabolism in Arabidopsis thaliana. Arabidopsis Book (2011) 1.30
Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa). New Phytol (2011) 1.28
To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism. Annu Rev Plant Biol (2014) 1.28
Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster. J Biol Chem (2012) 1.26
Formation of plant metabolic gene clusters within dynamic chromosomal regions. Proc Natl Acad Sci U S A (2011) 1.18
Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7. FEBS Lett (2011) 1.17
A genome scale metabolic network for rice and accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress. Rice (N Y) (2013) 1.16
Investigation of terpene diversification across multiple sequenced plant genomes. Proc Natl Acad Sci U S A (2014) 1.16
A serine carboxypeptidase-like acyltransferase is required for synthesis of antimicrobial compounds and disease resistance in oats. Plant Cell (2009) 1.15
Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula. Plant Cell (2010) 1.15
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. Plant Physiol (2012) 1.14
Cytochrome P450 CYP71BE5 in grapevine (Vitis vinifera) catalyzes the formation of the spicy aroma compound (-)-rotundone. J Exp Bot (2015) 1.13
Evolution of a complex locus for terpene biosynthesis in solanum. Plant Cell (2013) 1.10
A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygen-containing labdane-type diterpenes. Plant Physiol (2010) 1.08
Gene clusters for secondary metabolic pathways: an emerging theme in plant biology. Plant Physiol (2010) 1.07
The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism. Mol Plant (2014) 1.03
Rice terpene synthase 20 (OsTPS20) plays an important role in producing terpene volatiles in response to abiotic stresses. Protoplasma (2014) 1.02
Electrostatic effects on (di)terpene synthase product outcome. Chem Commun (Camb) (2011) 1.00
Cell type-specific chromatin decondensation of a metabolic gene cluster in oats. Plant Cell (2009) 0.99
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals. Biochem J (2011) 0.98
Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals. Phytochemistry (2012) 0.97
Domain loss has independently occurred multiple times in plant terpene synthase evolution. Plant J (2011) 0.96
Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters. Plant Cell (2014) 0.94
Modularity of plant metabolic gene clusters: a trio of linked genes that are collectively required for acylation of triterpenes in oat. Plant Cell (2013) 0.93
Contrasting ontogenetic trajectories for phenolic and terpenoid defences in Eucalyptus froggattii. Ann Bot (2013) 0.91
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis. Biochem J (2013) 0.91
Order in the playground: Formation of plant gene clusters in dynamic chromosomal regions. Mob Genet Elements (2012) 0.85
A Metabolic Gene Cluster in the Wheat W1 and the Barley Cer-cqu Loci Determines β-Diketone Biosynthesis and Glaucousness. Plant Cell (2016) 0.84
Plant metabolic clusters - from genetics to genomics. New Phytol (2016) 0.83
Dispersed benzoxazinone gene cluster: molecular characterization and chromosomal localization of glucosyltransferase and glucosidase genes in wheat and rye. Plant Physiol (2011) 0.82
Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis. Appl Microbiol Biotechnol (2015) 0.82
Gibberellin metabolism enzymes in rice. Plant Physiol (2006) 0.80
Evolution of serine carboxypeptidase-like acyltransferases in the monocots. Plant Signal Behav (2010) 0.79
Comparative proteomics reveals differential induction of both biotic and abiotic stress response associated proteins in rice during Xanthomonas oryzae pv. oryzae infection. Funct Integr Genomics (2015) 0.78
Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties. Front Chem (2014) 0.78
Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum. PLoS One (2015) 0.77
Delineation of metabolic gene clusters in plant genomes by chromatin signatures. Nucleic Acids Res (2016) 0.77
HpDTC1, a Stress-Inducible Bifunctional Diterpene Cyclase Involved in Momilactone Biosynthesis, Functions in Chemical Defence in the Moss Hypnum plumaeforme. Sci Rep (2016) 0.76
OsMPK6 plays a critical role in cell differentiation during early embryogenesis in Oryza sativa. J Exp Bot (2016) 0.76
Diterpene synthases and their responsible cyclic natural products. Nat Prod Bioprospect (2014) 0.75
Investigating inducible short-chain alcohol dehydrogenases/reductases clarifies rice oryzalexin biosynthesis. Plant J (2016) 0.75
The biosynthetic gene cluster for the cyanogenic glucoside dhurrin in Sorghum bicolor contains its co-expressed vacuolar MATE transporter. Sci Rep (2016) 0.75
The PhytoClust tool for metabolic gene clusters discovery in plant genomes. Nucleic Acids Res (2017) 0.75
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science (2002) 21.26
Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels. J Mol Biol (1996) 13.17
Interplant communication: airborne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves. Proc Natl Acad Sci U S A (1990) 11.30
Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice. Science (2003) 8.65
The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Plant Cell (1994) 6.50
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. Science (1997) 5.56
Plant terpenoid synthases: molecular biology and phylogenetic analysis. Proc Natl Acad Sci U S A (1998) 4.63
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
An overview of gibberellin metabolism enzyme genes and their related mutants in rice. Plant Physiol (2004) 3.32
Evolution of floral scent in Clarkia: novel patterns of S-linalool synthase gene expression in the C. breweri flower. Plant Cell (1996) 3.05
Genomic analysis of the terpenoid synthase ( AtTPS) gene family of Arabidopsis thaliana. Mol Genet Genomics (2002) 2.64
Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase. Proc Natl Acad Sci U S A (2002) 2.44
Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily. Plant Physiol (2004) 2.36
How plants communicate using the underground information superhighway. Trends Plant Sci (2004) 2.35
Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme. Biochemistry (2000) 2.31
Truncation of limonene synthase preprotein provides a fully active 'pseudomature' form of this monoterpene cyclase and reveals the function of the amino-terminal arginine pair. Biochemistry (1998) 2.27
The GA2 locus of Arabidopsis thaliana encodes ent-kaurene synthase of gibberellin biosynthesis. Plant Physiol (1998) 2.19
Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana. Plant J (1997) 2.18
Two Classes of Plant Antibiotics: Phytoalexins versus "Phytoanticipins" Plant Cell (1994) 2.16
Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. J Biol Chem (1996) 2.05
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.). Plant J (1996) 2.04
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products. Plant J (2004) 1.85
A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J Biol Chem (1996) 1.73
Involvement of Jasmonic Acid in Elicitor-Induced Phytoalexin Production in Suspension-Cultured Rice Cells. Plant Physiol (1996) 1.49
Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-alpha-bisabolene synthase from grand fir (Abies grandis). Proc Natl Acad Sci U S A (1998) 1.38
Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis. Arch Biochem Biophys (2001) 1.28
Diterpene synthesis in Stevia rebaudiana: recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway. Plant J (1999) 1.27
Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate. Biochemistry (2002) 1.26
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. Biochemistry (2003) 1.19
Biosynthesis of rice phytoalexins: identification of putative diterpene hydrocarbon precursors. Arch Biochem Biophys (1992) 1.07
Biosynthesis of cyclic diterpene hydrocarbons in rice cell suspensions: conversion of 9,10-syn-labda-8(17),13-dienyl diphosphate to 9beta-pimara-7,15-diene and stemar-13-ene. Arch Biochem Biophys (1996) 1.04
Rice seedlings release momilactone B into the environment. Phytochemistry (2003) 0.92
Isolation and identification of a potent allelopathic substance in rice root exudates. Physiol Plant (2002) 0.86
Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase. Proc Natl Acad Sci U S A (2002) 2.44
A modular approach for facile biosynthesis of labdane-related diterpenes. J Am Chem Soc (2007) 2.13
Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions. Plant Physiol (2004) 1.88
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products. Plant J (2004) 1.85
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. Appl Microbiol Biotechnol (2009) 1.80
Functional characterization of the rice kaurene synthase-like gene family. Phytochemistry (2006) 1.79
Gibberellin biosynthesis in bacteria: separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum. FEBS Lett (2008) 1.73
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice. Plant Cell (2009) 1.73
A functional genomics approach to tanshinone biosynthesis provides stereochemical insights. Org Lett (2009) 1.65
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis. Proc Natl Acad Sci U S A (2007) 1.64
Following evolution's lead to a single residue switch for diterpene synthase product outcome. Proc Natl Acad Sci U S A (2007) 1.64
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature (2010) 1.49
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc Natl Acad Sci U S A (2013) 1.44
Diterpene cyclases and the nature of the isoprene fold. Proteins (2010) 1.41
CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. Plant J (2010) 1.39
Probing the role of the DXDD motif in Class II diterpene cyclases. Chembiochem (2007) 1.39
Terpenoid synthase structures: a so far incomplete view of complex catalysis. Nat Prod Rep (2012) 1.39
MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells. Eur J Cancer (2010) 1.37
Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism. Plant Physiol (2007) 1.37
Increasing complexity of a diterpene synthase reaction with a single residue switch. J Am Chem Soc (2008) 1.36
A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase. J Am Chem Soc (2007) 1.34
Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase. Nat Chem Biol (2011) 1.33
Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa). New Phytol (2011) 1.28
To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism. Annu Rev Plant Biol (2014) 1.28
Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster. J Biol Chem (2012) 1.26
16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana. J Am Chem Soc (2007) 1.23
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 1.22
Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction. J Mol Biol (2006) 1.22
Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry (2005) 1.20
Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. J Am Chem Soc (2002) 1.19
Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys (2007) 1.18
Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis. J Am Chem Soc (2009) 1.18
Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7. FEBS Lett (2011) 1.17
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase. Arch Biochem Biophys (2005) 1.16
Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants. Phytochemistry (2009) 1.14
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. Plant Physiol (2012) 1.14
Syn- and anti-selective Prins cyclizations of delta,epsilon-unsaturated ketones to 1,3-halohydrins with Lewis acids. J Org Chem (2006) 1.14
Characterization and inhibition of a class II diterpene cyclase from Mycobacterium tuberculosis: implications for tuberculosis. J Biol Chem (2009) 1.13
Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. J Am Chem Soc (2012) 1.11
Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes. J Am Chem Soc (2005) 1.11
Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis. J Biol Chem (2012) 1.09
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. BMC Genomics (2014) 1.08
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. J Biol Chem (2008) 1.07
Synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate from D-arabitol. Org Lett (2004) 1.06
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis. Biochem J (2010) 1.06
Eremophilane sesquiterpenes from capsidiol. J Org Chem (2004) 1.04
Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae. Org Biomol Chem (2013) 1.02
Formation of the unusual semivolatile diterpene rhizathalene by the Arabidopsis class I terpene synthase TPS08 in the root stele is involved in defense against belowground herbivory. Plant Cell (2013) 1.02
Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J Biol Chem (2004) 1.01
Electrostatic effects on (di)terpene synthase product outcome. Chem Commun (Camb) (2011) 1.00
A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii. Chembiochem (2011) 1.00
Monoterpene biosynthesis pathway construction in Escherichia coli. Phytochemistry (2003) 1.00
Conformational Analysis of (+)-Germacrene A by Variable Temperature NMR and NOE Spectroscopy. Tetrahedron (2007) 0.99
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals. Biochem J (2011) 0.98
Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem (2007) 0.98
Synthesis of (+/-)-nosyberkol (isotuberculosinol, revised structure of edaxadiene) and (+/-)-tuberculosinol. Org Lett (2010) 0.97
Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals. Phytochemistry (2012) 0.97
Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS Chem Biol (2010) 0.96
Domain loss has independently occurred multiple times in plant terpene synthase evolution. Plant J (2011) 0.96
Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins. Plant J (2014) 0.96
Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphate. Arch Biochem Biophys (2007) 0.95
A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase. Org Lett (2012) 0.95
Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric CH4 hybrid cyclase. Arch Biochem Biophys (2005) 0.95
Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia. J Bacteriol (2013) 0.95
Novel product chemistry from mechanistic analysis of ent-copalyl diphosphate synthases from plant hormone biosynthesis. Angew Chem Int Ed Engl (2014) 0.95
Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals. Phytochemistry (2012) 0.94
Scope and mechanism of intramolecular aziridination of cyclopent-3-enyl-methylamines to 1-azatricyclo[2.2.1.0(2,6)]heptanes with lead tetraacetate. J Am Chem Soc (2009) 0.91
The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine. Biomaterials (2007) 0.91
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis. Biochem J (2013) 0.91
An ent-kaurene-derived diterpenoid virulence factor from Xanthomonas oryzae pv. oryzicola. New Phytol (2014) 0.90
Heat- or water-driven malleability in a highly recyclable covalent network polymer. Adv Mater (2014) 0.90
A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. J Biol Chem (2010) 0.90
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. J Biol Chem (2012) 0.90
Spatiotemporal analysis of particulate air pollution and ischemic heart disease mortality in Beijing, China. Environ Health (2014) 0.89
Total synthesis of (+/-)-cameroonan-7alpha-ol and biomimetic rearrangements to related nopsane sesquiterpenes. J Org Chem (2003) 0.89
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J Org Chem (2005) 0.88
Sonodynamic effect of an anti-inflammatory agent--emodin on macrophages. Ultrasound Med Biol (2011) 0.88
1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis. Biochim Biophys Acta (2013) 0.87
Structures, biogenetic relationships, and cytotoxicity of pimarane-derived diterpenes from Petalostigma pubescens. Phytochemistry (2005) 0.87