Published in Am J Epidemiol on September 01, 2004
Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ (2008) 2.62
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Correction of population stratification in large multi-ethnic association studies. PLoS One (2008) 1.59
Long-Term Risk of Atherosclerotic Cardiovascular Disease in US Adults With the Familial Hypercholesterolemia Phenotype. Circulation (2016) 1.47
Heterozygous familial hypercholesterolemia: an underrecognized cause of early cardiovascular disease. CMAJ (2006) 1.30
Optimal management of familial hypercholesterolemia: treatment and management strategies. Vasc Health Risk Manag (2010) 1.16
Giant Tuberous Xanthomas in a Case of Type IIA Hypercholesterolemia. J Cutan Aesthet Surg (2012) 1.06
Familial hypercholesterolemia: the lipids or the genes? Nutr Metab (Lond) (2011) 1.04
Cascade Screening for Familial Hypercholesterolemia (FH). PLoS Curr (2011) 0.98
Psoriasis and cardiovascular risk: strength in numbers. J Invest Dermatol (2010) 0.95
Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability. J Appl Physiol (1985) (2013) 0.91
LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives. Int Arch Med (2010) 0.91
No significant improvement of cardiovascular disease risk indicators by a lifestyle intervention in people with familial hypercholesterolemia compared to usual care: results of a randomised controlled trial. BMC Res Notes (2012) 0.83
A tailored lifestyle intervention to reduce the cardiovascular disease risk of individuals with Familial Hypercholesterolemia (FH): design of the PRO-FIT randomised controlled trial. BMC Public Health (2010) 0.83
MicroRNA-management of lipoprotein homeostasis. Circ Res (2014) 0.80
Can multiple lifestyle behaviours be improved in people with familial hypercholesterolemia? Results of a parallel randomised controlled trial. PLoS One (2012) 0.80
Seniors' perceptions of prescription drug advertisements: a pilot study of the potential impact on informed decision making. Patient Educ Couns (2010) 0.80
Genetic variants from lipid-related pathways and risk for incident myocardial infarction. PLoS One (2013) 0.79
Lipoprotein-apheresis: Austrian consensus on indication and performance of treatment. Wien Klin Wochenschr (2015) 0.79
The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction. Lipids Health Dis (2014) 0.79
Protective effects of Allium sativum against defects of hypercholesterolemia on pregnant rats and their offspring. Int J Clin Exp Med (2010) 0.78
My Approach to the Patient With Familial Hypercholesterolemia. Mayo Clin Proc (2016) 0.78
Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 0.78
Exploring Gaps of Family History Documentation in EHR for Precision Medicine -A Case Study of Familial Hypercholesterolemia Ascertainment. AMIA Jt Summits Transl Sci Proc (2016) 0.77
The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population. Lipids Health Dis (2015) 0.77
Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience). Cholesterol (2012) 0.77
Familial hypercholesterolemia and the atherosclerotic disease. Korean Circ J (2013) 0.77
Mendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the future. Curr Opin Endocrinol Diabetes Obes (2016) 0.76
Pharmacogenetic aspects in familial hypercholesterolemia with the special focus on FHMarburg (FH p.W556R). Clin Res Cardiol Suppl (2012) 0.76
Predicting non-adherence in patients with familial hypercholesterolemia. Eur J Clin Pharmacol (2014) 0.76
Successful Direct Adsorption of Lipoproteins (DALI) Apheresis During Pregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia. Open Cardiovasc Med J (2015) 0.76
Enhanced status of inflammation and endothelial activation in subjects with familial hypercholesterolaemia and their related unaffected family members: a case control study. Lipids Health Dis (2017) 0.75
Genome-Wide DNA Methylation Analysis and Epigenetic Variations Associated with Congenital Aortic Valve Stenosis (AVS). PLoS One (2016) 0.75
Squamous cell carcinoma developing in a long-standing case of tuberous xanthoma: An incident unreported hitherto. Indian Dermatol Online J (2015) 0.75
US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol (2016) 0.75
Evidence-based goals in LDL-C reduction. Clin Res Cardiol (2017) 0.75
Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells. Int J Obes (Lond) (2016) 0.75
Association of peripheral arterial and cardiovascular diseases in familial hypercholesterolemia. Arq Bras Cardiol (2014) 0.75
A model of care for familial hypercholesterolaemia: key role for clinical biochemistry. Clin Biochem Rev (2012) 0.75
The effects of rosuvastatin on lipid-lowering, inflammatory, antioxidant and fibrinolytics blood biomarkers are influenced by Val16Ala superoxide dismutase manganese-dependent gene polymorphism. Pharmacogenomics J (2016) 0.75
Statins: Cholesterol guidelines and Indian perspective. Indian J Endocrinol Metab (2015) 0.75
A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis. Eur J Hum Genet (2015) 0.75
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet (2002) 8.89
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet (2013) 3.87
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J (2013) 3.58
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis (2003) 2.97
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol (2002) 2.84
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin Chem (2008) 2.82
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70
CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. Am J Hum Genet (2008) 2.68
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Cost effectiveness analysis of different approaches of screening for familial hypercholesterolaemia. BMJ (2002) 2.55
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ (2010) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study. Eur Heart J (2008) 2.52
Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med (2002) 2.51
Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J (2008) 2.50
Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data. Am J Hum Genet (2010) 2.50
Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet (2011) 2.35
Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation (2004) 2.31
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet (2002) 2.27
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18
Familial hypercholesterolaemia: summary of NICE guidance. BMJ (2008) 2.18
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts. Int J Epidemiol (2008) 2.14
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
Left ventricular wall thickness and the presence of asymmetric hypertrophy in healthy young army recruits: data from the LARGE heart study. Circ Cardiovasc Imaging (2013) 1.98
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis (2009) 1.96
Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoS Med (2008) 1.95
Genetic tests for common diseases: new insights, old concerns. BMJ (2008) 1.95
Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. Ann Neurol (2007) 1.92
Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev (2008) 1.85
Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus. Clin Chem (2004) 1.83
Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation (2002) 1.79
Tri-county comprehensive assessment of risk factors for sporadic reportable bacterial enteric infection in children. J Infect Dis (2009) 1.76
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J (2011) 1.73
Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial. Am J Med Genet A (2004) 1.72
In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol (2002) 1.70
Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol (2006) 1.66
Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene. Arterioscler Thromb Vasc Biol (2003) 1.65
A collaboratively-derived science-policy research agenda. PLoS One (2012) 1.63
Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. Am J Epidemiol (2004) 1.61
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet (2011) 1.60
Identification and management of familial hypercholesterolaemia: what does it mean to primary care? Br J Gen Pract (2009) 1.55
Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment. Ann Hum Genet (2012) 1.53
Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors. J Mol Med (Berl) (2010) 1.51
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res (2013) 1.47
Cascade testing in familial hypercholesterolaemia: how should family members be contacted? Eur J Hum Genet (2005) 1.46
Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44
Bayesian meta-analysis of genetic association studies with different sets of markers. Am J Hum Genet (2008) 1.44
Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease. Thromb Haemost (2005) 1.41
Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial. J Health Psychol (2008) 1.41
Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth. J Mol Med (Berl) (2006) 1.40
European differences in the association between ACE I/D polymorphism and incidence of MI may be explained by gene-lipid interaction. Atherosclerosis (2006) 1.39
A population-based study of the risk of repeat clinical chorioamnionitis in Washington State, 1989-2008. Am J Obstet Gynecol (2012) 1.38
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). Hum Mol Genet (2011) 1.37
Diarrhea etiology in a pediatric emergency department: a case control study. Clin Infect Dis (2012) 1.36
ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk. Arterioscler Thromb Vasc Biol (2008) 1.34
APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. Mol Med (2010) 1.33
Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men. Arterioscler Thromb Vasc Biol (2002) 1.31
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J (2012) 1.30
Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK. Prev Med (2004) 1.30
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J Lipid Res (2006) 1.28
Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. Atherosclerosis (2010) 1.27
LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago. Am J Hum Genet (2006) 1.26
Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing. Clin Chem Lab Med (2008) 1.25
Telomere length in atherosclerosis and diabetes. Atherosclerosis (2009) 1.24
LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease. Mov Disord (2009) 1.22
Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS One (2012) 1.21
Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK. Patient Educ Couns (2008) 1.20
Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation (2009) 1.20
The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. Biochim Biophys Acta (2008) 1.19
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet (2009) 1.18
Determination of the functionality of common APOA5 polymorphisms. J Biol Chem (2005) 1.18
Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis. Arterioscler Thromb Vasc Biol (2013) 1.18
IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes (2006) 1.18
Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study. Eur Heart J (2009) 1.17
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. Hum Mol Genet (2009) 1.17
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin Sci (Lond) (2007) 1.17
APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study. J Lipid Res (2004) 1.16
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol (2012) 1.14
PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry. Circulation (2010) 1.14
Cardiovascular risk and diabetes. Are the methods of risk prediction satisfactory? Eur J Cardiovasc Prev Rehabil (2004) 1.14
Policy challenges of clinical genome sequencing. BMJ (2013) 1.14
The use of imputed values in the meta-analysis of genome-wide association studies. Genet Epidemiol (2011) 1.12