| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
|
Cell Metab
|
2007
|
4.75
|
|
2
|
Oxidative mechanism of arsenic toxicity and carcinogenesis.
|
Mol Cell Biochem
|
2004
|
2.07
|
|
3
|
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.
|
Biochem Biophys Res Commun
|
2003
|
1.91
|
|
4
|
G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.
|
Am J Physiol Cell Physiol
|
2004
|
1.85
|
|
5
|
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway.
|
Cancer Res
|
2007
|
1.85
|
|
6
|
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer.
|
Biochem Biophys Res Commun
|
2003
|
1.82
|
|
7
|
Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.
|
J Biol Chem
|
2006
|
1.78
|
|
8
|
Molecular mechanisms of arsenic carcinogenesis.
|
Mol Cell Biochem
|
2004
|
1.66
|
|
9
|
Metal-induced oxidative stress and signal transduction.
|
Free Radic Biol Med
|
2004
|
1.59
|
|
10
|
Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
|
Clin Cancer Res
|
2006
|
1.55
|
|
11
|
Cytoplasm-localized SIRT1 enhances apoptosis.
|
J Cell Physiol
|
2007
|
1.52
|
|
12
|
Confirmation of gene expression-based prediction of survival in non-small cell lung cancer.
|
Clin Cancer Res
|
2008
|
1.49
|
|
13
|
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration.
|
Am J Physiol Cell Physiol
|
2003
|
1.49
|
|
14
|
Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
|
Mol Pharmacol
|
2005
|
1.47
|
|
15
|
ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.
|
Oncogene
|
2005
|
1.46
|
|
16
|
A Shope Fibroma virus PYRIN-only protein modulates the host immune response.
|
Virus Genes
|
2007
|
1.41
|
|
17
|
Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species.
|
J Biol Chem
|
2002
|
1.41
|
|
18
|
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling.
|
Part Fibre Toxicol
|
2009
|
1.41
|
|
19
|
Predicting cancer drug response by proteomic profiling.
|
Clin Cancer Res
|
2006
|
1.39
|
|
20
|
Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals.
|
Chem Res Toxicol
|
2004
|
1.37
|
|
21
|
Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells.
|
Free Radic Biol Med
|
2006
|
1.32
|
|
22
|
Occupational toxicology of nickel and nickel compounds.
|
J Environ Pathol Toxicol Oncol
|
2009
|
1.27
|
|
23
|
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.
|
Proc Natl Acad Sci U S A
|
2002
|
1.26
|
|
24
|
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression.
|
Carcinogenesis
|
2006
|
1.25
|
|
25
|
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.
|
J Hepatol
|
2008
|
1.25
|
|
26
|
Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA.
|
Nucleic Acids Res
|
2006
|
1.23
|
|
27
|
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
|
Infect Immun
|
2006
|
1.23
|
|
28
|
Antioxidant properties of fruit and vegetable juices: more to the story than ascorbic acid.
|
Ann Clin Lab Sci
|
2002
|
1.22
|
|
29
|
Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1.
|
Breast Cancer Res Treat
|
2011
|
1.21
|
|
30
|
Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.
|
Carcinogenesis
|
2004
|
1.21
|
|
31
|
Diseases caused by silica: mechanisms of injury and disease development.
|
Int Immunopharmacol
|
2002
|
1.20
|
|
32
|
Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.
|
J Biol Chem
|
2003
|
1.19
|
|
33
|
Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells.
|
Chem Res Toxicol
|
2010
|
1.19
|
|
34
|
trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells.
|
Clin Cancer Res
|
2004
|
1.18
|
|
35
|
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
|
Toxicol Sci
|
2011
|
1.16
|
|
36
|
Alcohol-induced oxidative stress and cell responses.
|
J Gastroenterol Hepatol
|
2006
|
1.16
|
|
37
|
Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.
|
Cell Cycle
|
2009
|
1.16
|
|
38
|
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer.
|
Oncogene
|
2005
|
1.16
|
|
39
|
Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells.
|
Mol Cell Biochem
|
2004
|
1.15
|
|
40
|
Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization.
|
J Biol Chem
|
2004
|
1.15
|
|
41
|
Autophagy is a protective response to ethanol neurotoxicity.
|
Autophagy
|
2012
|
1.15
|
|
42
|
Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells.
|
J Immunol
|
2006
|
1.15
|
|
43
|
Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells.
|
Cancer Res
|
2010
|
1.14
|
|
44
|
Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells.
|
Carcinogenesis
|
2006
|
1.14
|
|
45
|
Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells.
|
Cancer Res
|
2004
|
1.13
|
|
46
|
Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism.
|
Toxicol Appl Pharmacol
|
2010
|
1.12
|
|
47
|
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
|
Cancer Res
|
2003
|
1.12
|
|
48
|
New perspectives in arsenic-induced cell signal transduction.
|
J Inorg Biochem
|
2003
|
1.12
|
|
49
|
Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.
|
Toxicol Appl Pharmacol
|
2012
|
1.11
|
|
50
|
Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression.
|
J Cell Physiol
|
2006
|
1.10
|
|
51
|
Oxidative stress and metal carcinogenesis.
|
Free Radic Biol Med
|
2012
|
1.09
|
|
52
|
MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2.
|
Int J Cancer
|
2006
|
1.09
|
|
53
|
Molecular mechanisms of Cr(VI)-induced carcinogenesis.
|
Mol Cell Biochem
|
2002
|
1.09
|
|
54
|
Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C.
|
Cancer Res
|
2002
|
1.09
|
|
55
|
Role of reactive oxygen species and MAPKs in vanadate-induced G(2)/M phase arrest.
|
Free Radic Biol Med
|
2003
|
1.08
|
|
56
|
Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function.
|
Neurosci Lett
|
2006
|
1.08
|
|
57
|
Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses.
|
Mol Cell Biochem
|
2004
|
1.08
|
|
58
|
Carcinogenic effect of nickel compounds.
|
Mol Cell Biochem
|
2005
|
1.07
|
|
59
|
JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma.
|
Mol Cancer
|
2009
|
1.07
|
|
60
|
Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress.
|
J Neurosci Res
|
2008
|
1.06
|
|
61
|
Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein.
|
Biochem J
|
2005
|
1.06
|
|
62
|
PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.
|
Environ Health Perspect
|
2008
|
1.06
|
|
63
|
Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.
|
PLoS One
|
2012
|
1.05
|
|
64
|
Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species.
|
Free Radic Biol Med
|
2007
|
1.05
|
|
65
|
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.
|
Toxicol Sci
|
2011
|
1.05
|
|
66
|
Effects of welding fumes of differing composition and solubility on free radical production and acute lung injury and inflammation in rats.
|
Toxicol Sci
|
2003
|
1.04
|
|
67
|
Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.
|
Mol Cancer
|
2010
|
1.04
|
|
68
|
Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway.
|
J Nanobiotechnology
|
2009
|
1.04
|
|
69
|
p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells.
|
J Biol Chem
|
2002
|
1.03
|
|
70
|
Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation.
|
Toxicol Sci
|
2012
|
1.03
|
|
71
|
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.
|
J Cell Biol
|
2004
|
1.03
|
|
72
|
Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.
|
Mol Cell Biochem
|
2005
|
1.03
|
|
73
|
Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta.
|
Neurotox Res
|
2009
|
1.02
|
|
74
|
Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity.
|
J Neurosci Res
|
2009
|
1.02
|
|
75
|
Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells.
|
Toxicol Appl Pharmacol
|
2011
|
1.01
|
|
76
|
Cancer prevention with promising natural products: mechanisms of action and molecular targets.
|
Anticancer Agents Med Chem
|
2012
|
1.01
|
|
77
|
NADPH oxidase 4 mediates insulin-stimulated HIF-1α and VEGF expression, and angiogenesis in vitro.
|
PLoS One
|
2012
|
1.01
|
|
78
|
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells.
|
Toxicol Appl Pharmacol
|
2011
|
1.01
|
|
79
|
Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro.
|
Oncogene
|
2003
|
1.00
|
|
80
|
Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability.
|
J Toxicol Environ Health A
|
2010
|
1.00
|
|
81
|
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.
|
Mol Cancer Ther
|
2007
|
0.99
|
|
82
|
Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.
|
Clin Cancer Res
|
2010
|
0.99
|
|
83
|
Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.
|
Mol Cancer Ther
|
2011
|
0.99
|
|
84
|
PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.
|
Mol Biol Cell
|
2002
|
0.99
|
|
85
|
Quercitrin protects skin from UVB-induced oxidative damage.
|
Toxicol Appl Pharmacol
|
2013
|
0.99
|
|
86
|
Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells.
|
Toxicol Appl Pharmacol
|
2010
|
0.99
|
|
87
|
Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction.
|
Mol Cell Biochem
|
2005
|
0.99
|
|
88
|
Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line.
|
Toxicol Sci
|
2009
|
0.98
|
|
89
|
Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.
|
Blood
|
2005
|
0.98
|
|
90
|
A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells.
|
Oncogene
|
2004
|
0.97
|
|
91
|
p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.
|
J Biol Chem
|
2010
|
0.97
|
|
92
|
Dietary flavonoids as cancer prevention agents.
|
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
|
2011
|
0.96
|
|
93
|
Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
|
PLoS One
|
2012
|
0.96
|
|
94
|
Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein.
|
Biochemistry
|
2005
|
0.96
|
|
95
|
Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress.
|
PLoS One
|
2012
|
0.96
|
|
96
|
Ethanol induces endoplasmic reticulum stress in the developing brain.
|
Alcohol Clin Exp Res
|
2011
|
0.96
|
|
97
|
Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.
|
J Pharmacol Exp Ther
|
2006
|
0.96
|
|
98
|
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.
|
Carcinogenesis
|
2004
|
0.95
|
|
99
|
Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells.
|
Int J Cancer
|
2008
|
0.95
|
|
100
|
Signaling by carcinogenic metals and metal-induced reactive oxygen species.
|
Mutat Res
|
2003
|
0.95
|
|
101
|
Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression.
|
Cancer Res
|
2007
|
0.94
|
|
102
|
An integrative genomic and proteomic approach to chemosensitivity prediction.
|
Int J Oncol
|
2009
|
0.94
|
|
103
|
Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons.
|
J Neurosci Res
|
2007
|
0.93
|
|
104
|
Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase.
|
Clin Cancer Res
|
2009
|
0.93
|
|
105
|
Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development.
|
J Biol Chem
|
2004
|
0.93
|
|
106
|
Oxidative stress and chromium(VI) carcinogenesis.
|
J Environ Pathol Toxicol Oncol
|
2008
|
0.93
|
|
107
|
Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin.
|
Int J Oncol
|
2010
|
0.92
|
|
108
|
Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway.
|
Toxicol Appl Pharmacol
|
2012
|
0.92
|
|
109
|
Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages.
|
Am J Physiol Cell Physiol
|
2002
|
0.92
|
|
110
|
Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells.
|
J Nutr
|
2006
|
0.92
|
|
111
|
Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway.
|
Environ Health Perspect
|
2010
|
0.92
|
|
112
|
Inhibition of NF-kappaB stabilizes gadd45alpha mRNA.
|
Biochem Biophys Res Commun
|
2005
|
0.91
|
|
113
|
Population-based molecular prognosis of breast cancer by transcriptional profiling.
|
Clin Cancer Res
|
2007
|
0.91
|
|
114
|
PbCrO4 mediates cellular responses via reactive oxygen species.
|
Mol Cell Biochem
|
2004
|
0.91
|
|
115
|
Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo.
|
Apoptosis
|
2011
|
0.90
|
|
116
|
Differential role of hydrogen peroxide in UV-induced signal transduction.
|
Mol Cell Biochem
|
2002
|
0.90
|
|
117
|
Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways.
|
Toxicol Appl Pharmacol
|
2012
|
0.90
|
|
118
|
Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain.
|
J Neurosci Res
|
2011
|
0.89
|
|
119
|
Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages.
|
J Cell Physiol
|
2005
|
0.89
|
|
120
|
Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.
|
Alcohol Clin Exp Res
|
2010
|
0.89
|
|
121
|
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells.
|
J Biol Chem
|
2008
|
0.88
|
|
122
|
Continuously generated H2O2 stimulates the proliferation and osteoblastic differentiation of human periodontal ligament fibroblasts.
|
J Cell Biochem
|
2012
|
0.88
|
|
123
|
Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway.
|
Toxicol Sci
|
2012
|
0.88
|
|
124
|
Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.
|
Int J Oncol
|
2011
|
0.88
|
|
125
|
Intracellular signal transduction of cells in response to carcinogenic metals.
|
Crit Rev Oncol Hematol
|
2002
|
0.88
|
|
126
|
The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src.
|
J Cell Sci
|
2003
|
0.88
|
|
127
|
Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings.
|
Mol Cell Biochem
|
2004
|
0.87
|
|
128
|
Free radical scavenging, DNA protection, and inhibition of lipid peroxidation mediated by uric acid.
|
Ann Clin Lab Sci
|
2005
|
0.87
|
|
129
|
Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages.
|
Toxicol In Vitro
|
2011
|
0.87
|
|
130
|
Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression.
|
Cell Mol Life Sci
|
2010
|
0.87
|
|
131
|
Involvement of hydrogen peroxide in asbestos-induced NFAT activation.
|
Mol Cell Biochem
|
2002
|
0.87
|
|
132
|
Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway.
|
Br J Pharmacol
|
2011
|
0.86
|
|
133
|
Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species.
|
J Cell Physiol
|
2003
|
0.86
|
|
134
|
Upstream signal transduction of NF-kappaB activation.
|
Curr Drug Targets Inflamm Allergy
|
2002
|
0.86
|
|
135
|
Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.
|
Environ Health Perspect
|
2002
|
0.85
|
|
136
|
Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract.
|
J Biol Chem
|
2003
|
0.85
|
|
137
|
Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients.
|
Br J Nutr
|
2011
|
0.85
|
|
138
|
Benzo[a]pyrene-3,6-dione inhibited VEGF expression through inducing HIF-1alpha degradation.
|
Biochem Biophys Res Commun
|
2007
|
0.85
|
|
139
|
Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells.
|
J Inorg Biochem
|
2002
|
0.85
|
|
140
|
NF-kappaB, a pivotal transcription factor in silica-induced diseases.
|
Mol Cell Biochem
|
2002
|
0.84
|
|
141
|
As(III) transcriptionally activates the gadd45a gene via the formation of H2O2.
|
Free Radic Biol Med
|
2006
|
0.84
|
|
142
|
DNA cleavage by the photolysis of cyclopentadienyl metal complexes: mechanistic studies and sequence selectivity of strand scission by CpW(CO)3CH3.
|
J Org Chem
|
2005
|
0.84
|
|
143
|
Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutant.
|
J Biol Chem
|
2001
|
0.83
|
|
144
|
Generation of reactive oxygen species in the enzymatic reduction of PbCrO4 and related DNA damage.
|
Mol Cell Biochem
|
2002
|
0.83
|
|
145
|
Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro.
|
J Biol Chem
|
2002
|
0.83
|
|
146
|
Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction.
|
Mol Cell Biochem
|
2004
|
0.83
|
|
147
|
Roles of the ERK, JNK/AP-1/cyclin D1-CDK4 pathway in silica-induced cell cycle changes in human embryo lung fibroblast cells.
|
Cell Biol Int
|
2011
|
0.83
|
|
148
|
Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling.
|
Toxicol Appl Pharmacol
|
2013
|
0.83
|
|
149
|
Chronic insulin treatment causes insulin resistance in 3T3-L1 adipocytes through oxidative stress.
|
Free Radic Res
|
2008
|
0.83
|
|
150
|
Concentrations of arsenic, chromium, and nickel in toenail samples from Appalachian Kentucky residents.
|
J Environ Pathol Toxicol Oncol
|
2011
|
0.82
|
|
151
|
Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.
|
Mol Cell Biochem
|
2005
|
0.82
|
|
152
|
Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells.
|
J Nutr Biochem
|
2010
|
0.82
|
|
153
|
Vanadate activated Akt and promoted S phase entry.
|
Mol Cell Biochem
|
2004
|
0.82
|
|
154
|
Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages.
|
Toxicol In Vitro
|
2013
|
0.82
|
|
155
|
Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells.
|
Mol Cell Biochem
|
2004
|
0.82
|
|
156
|
Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells.
|
Mol Cells
|
2009
|
0.81
|
|
157
|
Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.
|
Toxicol Lett
|
2008
|
0.81
|
|
158
|
GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells.
|
Int J Oncol
|
2012
|
0.81
|
|
159
|
Chromium (VI) induces insulin resistance in 3T3-L1 adipocytes through elevated reactive oxygen species generation.
|
Free Radic Res
|
2008
|
0.81
|
|
160
|
Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts.
|
Toxicol Lett
|
2007
|
0.81
|
|
161
|
3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.
|
PLoS One
|
2012
|
0.81
|
|
162
|
Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice.
|
J Environ Pathol Toxicol Oncol
|
2002
|
0.81
|
|
163
|
Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cells.
|
Mol Carcinog
|
2009
|
0.80
|
|
164
|
In vivo bioassays of acute asbestosis and its correlation with ESR spectroscopy and imaging in redox status.
|
Mol Cell Biochem
|
2002
|
0.80
|
|
165
|
Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant.
|
Mol Cell Biochem
|
2004
|
0.80
|
|
166
|
ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells.
|
Mol Cell Biochem
|
2005
|
0.80
|
|
167
|
Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis.
|
Toxicol Sci
|
2012
|
0.80
|
|
168
|
Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblasts.
|
J Environ Pathol Toxicol Oncol
|
2002
|
0.80
|
|
169
|
Critical role of poly(ADP-ribose) polymerase-1 in modulating the mode of cell death caused by continuous oxidative stress.
|
J Cell Biochem
|
2009
|
0.80
|
|
170
|
Effect of ascorbic Acid and thiamine supplementation at different concentrations on lead toxicity in liver.
|
Ann Occup Hyg
|
2007
|
0.80
|
|
171
|
The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction.
|
Toxicol Appl Pharmacol
|
2009
|
0.80
|
|
172
|
The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivation.
|
Biochem Pharmacol
|
2005
|
0.80
|
|
173
|
Selection of nutrients for prevention or amelioration of lead-induced learning and memory impairment in rats.
|
Ann Occup Hyg
|
2009
|
0.79
|
|
174
|
Tungsten carbide-cobalt particles activate Nrf2 and its downstream target genes in JB6 cells possibly by ROS generation.
|
J Environ Pathol Toxicol Oncol
|
2010
|
0.79
|
|
175
|
MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cells.
|
Chem Res Toxicol
|
2002
|
0.79
|
|
176
|
Induction of miR-21-PDCD4 signaling by UVB in JB6 cells involves ROS-mediated MAPK pathways.
|
Exp Toxicol Pathol
|
2013
|
0.79
|
|
177
|
Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
|
J Ethnopharmacol
|
2005
|
0.79
|
|
178
|
Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells.
|
Toxicol Appl Pharmacol
|
2003
|
0.79
|
|
179
|
The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.
|
Toxicol Sci
|
2010
|
0.79
|
|
180
|
Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B.
|
Mol Cell Biochem
|
2006
|
0.79
|
|
181
|
The immunopharmacological properties of transforming growth factor beta.
|
Int Immunopharmacol
|
2005
|
0.79
|
|
182
|
Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway.
|
Toxicol Lett
|
2005
|
0.78
|
|
183
|
Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathways.
|
Exp Cell Res
|
2002
|
0.78
|
|
184
|
Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash.
|
J Biosci
|
2003
|
0.78
|
|
185
|
Inhibition of benzo(a)pyrene-induced cell cycle progression by all-trans retinoic acid partly through cyclin D1/E2F-1 pathway in human embryo lung fibroblasts.
|
Cell Biol Int
|
2006
|
0.78
|
|
186
|
NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis.
|
Mol Cell Biochem
|
2004
|
0.78
|
|
187
|
Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes.
|
Toxicol Appl Pharmacol
|
2011
|
0.78
|
|
188
|
Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells.
|
PLoS One
|
2012
|
0.78
|
|
189
|
Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway.
|
Nutr Cancer
|
2004
|
0.78
|
|
190
|
Environmental health research in the post-genome era: new fields, new challenges, and new opportunities.
|
J Toxicol Environ Health B Crit Rev
|
2005
|
0.78
|
|
191
|
Cancer stem cells in the mechanism of metal carcinogenesis.
|
J Environ Pathol Toxicol Oncol
|
2012
|
0.77
|
|
192
|
Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression.
|
Toxicol Appl Pharmacol
|
2013
|
0.77
|
|
193
|
Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.
|
J Environ Pathol Toxicol Oncol
|
2013
|
0.76
|
|
194
|
Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells.
|
Mol Cell Biochem
|
2004
|
0.76
|
|
195
|
Continuous presence of H₂O₂ induces mitochondrial-mediated, MAPK- and caspase-independent growth inhibition and cytotoxicity in human gingival fibroblasts.
|
Toxicol In Vitro
|
2012
|
0.76
|
|
196
|
Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression.
|
Mol Cell Biochem
|
2005
|
0.75
|
|
197
|
Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway.
|
Cell Biol Int
|
2008
|
0.75
|
|
198
|
[Cell cycle alterations of human embryo lung fibroblasts induced by benzo(a)pyrene is positively regulated by cyclin D1 and CDK4].
|
Wei Sheng Yan Jiu
|
2008
|
0.75
|
|
199
|
Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats.
|
Phytomedicine
|
2012
|
0.75
|
|
200
|
[Role of telomerase in silica induced human cell transformation].
|
Wei Sheng Yan Jiu
|
2004
|
0.75
|
|
201
|
The role of phosphatidylinositol-3 kinase in vanadate-promoted S phase entry.
|
Mol Cell Biochem
|
2004
|
0.75
|
|
202
|
Silica induces cell cycle changes through PI-3K/AP-1 pathway in human embryo lung fibroblast cells.
|
Cell Biochem Funct
|
2010
|
0.75
|
|
203
|
Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.
|
Nihon Arukoru Yakubutsu Igakkai Zasshi
|
2007
|
0.75
|