Published in Mol Cell Biol on October 01, 2004
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res (2007) 3.09
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A (2007) 2.56
A transposon and transposase system for human application. Mol Ther (2010) 2.28
Site-directed transposon integration in human cells. Nucleic Acids Res (2007) 1.74
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc Natl Acad Sci U S A (2005) 1.72
Comparative analysis of transposable element vector systems in human cells. Mol Ther (2010) 1.66
Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays (2010) 1.42
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood (2005) 1.40
Hybrid lentivirus-transposon vectors with a random integration profile in human cells. Mol Ther (2009) 1.26
Mutational derivatives of PhiC31 integrase with increased efficiency and specificity. Mol Ther (2008) 1.23
Hyperactive piggyBac gene transfer in human cells and in vivo. Hum Gene Ther (2011) 1.21
The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Hum Mol Genet (2011) 1.18
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity. Gene Ther (2009) 1.17
DDE transposases: Structural similarity and diversity. Adv Drug Deliv Rev (2010) 1.16
Postintegrative gene silencing within the Sleeping Beauty transposition system. Mol Cell Biol (2007) 1.15
Contemporary approaches for modifying the mouse genome. Physiol Genomics (2008) 1.10
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Hum Gene Ther (2009) 1.08
Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies. Curr Gene Ther (2011) 1.08
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD). Blood (2007) 1.07
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Mol Ther (2011) 1.04
Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. Transl Res (2013) 1.01
PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev (2010) 1.00
Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res (2008) 0.99
Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer. Oncotarget (2015) 0.95
Pigs taking wing with transposons and recombinases. Genome Biol (2007) 0.94
A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon. Mol Ther Nucleic Acids (2012) 0.93
Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase. BMC Biotechnol (2008) 0.93
Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease. Biochemistry (2007) 0.92
Mutagenesis in rodents using the L1 retrotransposon. Genome Biol (2007) 0.92
Passport, a native Tc1 transposon from flatfish, is functionally active in vertebrate cells. Nucleic Acids Res (2009) 0.91
DNA transposon-based gene vehicles - scenes from an evolutionary drive. J Biomed Sci (2013) 0.89
Transposon tools hopping in vertebrates. Brief Funct Genomic Proteomic (2008) 0.87
Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat. Genetics (2012) 0.86
Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo. Hum Gene Ther (2014) 0.86
Mariner Mos1 transposase optimization by rational mutagenesis. Genetica (2009) 0.85
Identification and characterization of a gain-of-function RAG-1 mutant. Mol Cell Biol (2006) 0.85
Transposon mutagenesis in mice. Methods Mol Biol (2009) 0.85
NMR structural analysis of Sleeping Beauty transposase binding to DNA. Protein Sci (2014) 0.84
Transgenic zebrafish using transposable elements. Methods Cell Biol (2011) 0.84
Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration. PLoS One (2013) 0.84
A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos. BMC Res Notes (2010) 0.83
Quantitative analysis of α-L-iduronidase expression in immunocompetent mice treated with the Sleeping Beauty transposon system. PLoS One (2013) 0.83
Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon. Hepatology (2009) 0.83
Driving DNA transposition by lentiviral protein transduction. Mob Genet Elements (2014) 0.81
Viral hybrid vectors for somatic integration - are they the better solution? Viruses (2009) 0.81
High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene. Biochemistry (2010) 0.81
Efficient sleeping beauty DNA transposition from DNA minicircles. Mol Ther Nucleic Acids (2013) 0.79
Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem Cells Int (2011) 0.78
Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells. Nucleic Acids Res (2012) 0.77
β-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon. J Cell Biochem (2011) 0.76
Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers. Cancer Biol Ther (2015) 0.76
Biochemical Characterization of Kat1: a Domesticated hAT-Transposase that Induces DNA Hairpin Formation and MAT-Switching. Sci Rep (2016) 0.76
Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo. Hum Gene Ther (2010) 0.76
Structural Determinants of Sleeping Beauty Transposase Activity. Mol Ther (2016) 0.75
The N-terminal zinc finger domain of Tgf2 transposase contributes to DNA binding and to transposition activity. Sci Rep (2016) 0.75
Mobilization of DNA transposable elements from lentiviral vectors. Mob Genet Elements (2011) 0.75
Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine. Genes Dis (2017) 0.75
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell (1997) 8.68
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther (1999) 8.28
High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther (1999) 5.17
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat Genet (2000) 4.35
Tn5 in vitro transposition. J Biol Chem (1998) 3.66
Hyperactive transposase mutants of the Himar1 mariner transposon. Proc Natl Acad Sci U S A (1999) 3.45
AT-hook motifs identified in a wide variety of DNA-binding proteins. Nucleic Acids Res (1998) 3.37
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
Resident aliens: the Tc1/mariner superfamily of transposable elements. Trends Genet (1999) 3.30
Transposition and gene disruption in the male germline of the mouse. Genesis (2001) 2.98
Regulated transposition of a fish transposon in the mouse germ line. Proc Natl Acad Sci U S A (2001) 2.78
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71
Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A (2001) 2.51
Modern thoughts on an ancyent marinere: function, evolution, regulation. Annu Rev Genet (1997) 2.36
Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo. Nat Biotechnol (2002) 2.31
Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. J Mol Biol (2002) 2.30
Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J Mol Biol (2000) 2.28
Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements. Mol Biol Evol (1995) 2.13
Development of hyperactive sleeping beauty transposon vectors by mutational analysis. Mol Ther (2004) 2.13
Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A (2002) 2.13
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
Sleeping beauty transposition: biology and applications for molecular therapy. Mol Ther (2004) 2.08
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition. J Biol Chem (2002) 1.92
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
Identification of functional domains and evolution of Tc1-like transposable elements. Proc Natl Acad Sci U S A (1996) 1.56
Characterization of the Caenorhabditis elegans Tc1 transposase in vivo and in vitro. Genes Dev (1993) 1.56
DNA binding activities of the Caenorhabditis elegans Tc3 transposase. Nucleic Acids Res (1994) 1.46
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Nucleic Acids Res (2003) 1.45
Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo. Mol Ther (2003) 1.42
Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Mol Cell Biol (2004) 1.41
In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues. Proc Natl Acad Sci U S A (2001) 1.40
What restricts the activity of mariner-like transposable elements. Trends Genet (1997) 1.39
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther (2002) 1.39
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Mol Cell Biol (2003) 1.37
Mutations in the mariner transposase: the D,D(35)E consensus sequence is nonfunctional. Proc Natl Acad Sci U S A (1997) 1.37
Evidence that the cis preference of the Tn5 transposase is caused by nonproductive multimerization. Genes Dev (1994) 1.31
Characterization of two hypertransposing Tn5 mutants. J Bacteriol (1992) 1.26
A helix-turn-helix DNA-binding motif predicted for transposases of DNA transposons. Mol Gen Genet (1997) 1.21
Tn5 transposase mutants that alter DNA binding specificity. J Mol Biol (1997) 1.20
Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies. Methods Mol Biol (2004) 1.13
Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer. Gene Ther (2003) 1.10
Transposition of the Drosophila hydei Minos transposon in the mouse germ line. Genomics (2003) 1.03
Identification and analysis of a hyperactive mutant form of Drosophila P-element transposase. Genetics (2002) 0.98
Transposon-based RNAi delivery system for generating knockdown cell lines. Biochem Biophys Res Commun (2004) 0.95
Two classes of Tn10 transposase mutants that suppress mutations in the Tn10 terminal inverted repeat. Genetics (1996) 0.82
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med (2006) 13.51
Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med (2011) 11.01
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature (2006) 10.95
Gene Ontology annotations at SGD: new data sources and annotation methods. Nucleic Acids Res (2007) 9.03
Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res (2011) 8.57
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet (2003) 6.95
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 5.50
RNA interference in adult mice. Nature (2002) 5.33
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol (2007) 5.04
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol Ther (2006) 4.64
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood (2002) 4.60
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med (2010) 4.07
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J Virol (2008) 3.79
Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol (2009) 3.70
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. J Virol (2004) 3.65
Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome. Nucleic Acids Res (2006) 3.59
Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA (2010) 3.40
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (2006) 3.40
Saccharomyces Genome Database provides mutant phenotype data. Nucleic Acids Res (2009) 3.38
Expanded protein information at SGD: new pages and proteome browser. Nucleic Acids Res (2006) 3.31
Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J Virol (2005) 3.28
Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol (2003) 3.15
High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol (2005) 3.10
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med (2004) 2.96
Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther (2003) 2.95
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. J Virol (2006) 2.94
Long-term safety and efficacy of factor IX gene therapy in hemophilia B. N Engl J Med (2014) 2.92
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest (2011) 2.83
AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat Genet (2003) 2.81
Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. Blood (2003) 2.74
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer (2003) 2.67
Training Future Scientists: Predicting First-year Minority Student Participation in Health Science Research. Res High Educ (2008) 2.66
Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A (2007) 2.56
Site-specific genomic integration produces therapeutic Factor IX levels in mice. Nat Biotechnol (2002) 2.54
Atlas - a data warehouse for integrative bioinformatics. BMC Bioinformatics (2005) 2.51
Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Mol Ther (2003) 2.49
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med (2013) 2.47
In vivo activity of nuclease-resistant siRNAs. RNA (2004) 2.33
Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo. Nat Biotechnol (2002) 2.31
Diagnosis and treatment of abdominal cocoon: a report of 24 cases. Am J Surg (2009) 2.19
Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep (2011) 2.17
Inclusion of immigrant status in smoking prevalence statistics. Am J Public Health (2003) 2.16
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 2.09
Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Hum Gene Ther (2005) 2.06
Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Mol Ther (2008) 2.01
Several acneiform papules and nodules on the neck. J Dtsch Dermatol Ges (2013) 1.98
Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. J Acquir Immune Defic Syndr (2011) 1.98
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol (2009) 1.96
Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci (2008) 1.92
Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol (2010) 1.92
YeastMine--an integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit. Database (Oxford) (2012) 1.92
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. J Clin Invest (2010) 1.91
A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc Res (2007) 1.91
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell (2012) 1.84
Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ Res (2012) 1.84
An overview of the BioCreative 2012 Workshop Track III: interactive text mining task. Database (Oxford) (2013) 1.82
Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med (2013) 1.81
Site-directed transposon integration in human cells. Nucleic Acids Res (2007) 1.74
Spatial-temporal clusters and risk factors of hand, foot, and mouth disease at the district level in Guangdong Province, China. PLoS One (2013) 1.74
A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction. J Virol (2002) 1.71
Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapy. Clin Infect Dis (2011) 1.70
Protease inhibitor levels in hair strongly predict virologic response to treatment. AIDS (2009) 1.68
Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries. Chem Biol (2010) 1.67
Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther (2005) 1.67
Casein kinase iδ mutations in familial migraine and advanced sleep phase. Sci Transl Med (2013) 1.65
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med (2012) 1.63
Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol Ther (2007) 1.51
Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice. Mol Ther (2002) 1.51
Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo. Mol Ther (2007) 1.51
Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation. Mol Ther (2008) 1.49
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics (2009) 1.46
Migrants and tuberculosis: analysing epidemiological data with ethnography. Aust N Z J Public Health (2008) 1.46
Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J Am Chem Soc (2005) 1.46
Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation (2009) 1.45
MicroRNA expression characterizes oligometastasis(es). PLoS One (2011) 1.45
Web servers and services for electrostatics calculations with APBS and PDB2PQR. J Comput Chem (2011) 1.45
Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo. Mol Ther (2003) 1.42
Expression profile of microRNAs in c-Myc induced mouse mammary tumors. Breast Cancer Res Treat (2008) 1.41
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology (2010) 1.41
Combinatorial RNAi: a winning strategy for the race against evolving targets? Mol Ther (2007) 1.40
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther (2002) 1.39
Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia. Am J Obstet Gynecol (2006) 1.38
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest (2013) 1.38
Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury. Am J Respir Crit Care Med (2008) 1.38
Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 1.37
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Mol Cell Biol (2003) 1.37
Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol (2006) 1.36
Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant (2010) 1.36