Published in Gastroenterology on October 01, 2004
Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest (2009) 2.79
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27
Cancer stem cells in the development of liver cancer. J Clin Invest (2013) 2.06
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
Genetics of hepatocellular carcinoma. World J Gastroenterol (2007) 1.64
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer (2008) 1.59
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol (2008) 1.56
Role of Wnt/β-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol (2009) 1.55
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon. Oncotarget (2012) 1.55
siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia (2007) 1.51
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease. Dig Dis Sci (2013) 1.48
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Clin Cancer Res (2012) 1.44
Novel therapeutic strategies for targeting liver cancer stem cells. Int J Biol Sci (2011) 1.39
Wnt signaling in liver cancer. Curr Drug Targets (2008) 1.34
Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview. J Transl Med (2011) 1.33
Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther (2009) 1.31
Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia (2008) 1.28
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology (2015) 1.20
Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16
Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells. PLoS One (2011) 1.16
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer (2009) 1.14
Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer (2009) 1.12
Cancer stem cells and hepatocellular carcinoma. Cancer Biol Ther (2009) 1.11
WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci (2007) 1.11
The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update. Protein Cell (2014) 1.10
An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET). Br J Cancer (2009) 1.08
Wnt/beta-catenin signaling in hepatic organogenesis. Organogenesis (2008) 1.05
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer (2011) 1.03
R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. J Hepatol (2006) 1.02
Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology (2009) 1.01
Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray. J Cancer Res Clin Oncol (2006) 0.99
Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc Natl Acad Sci U S A (2011) 0.99
Repair and regeneration: opportunities for carcinogenesis from tissue stem cells. J Cell Mol Med (2006) 0.98
Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol Cancer Res (2010) 0.98
Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells. Oncotarget (2015) 0.95
Dickkopfs and Wnt/β-catenin signalling in liver cancer. World J Clin Oncol (2011) 0.94
Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion. PLoS One (2012) 0.92
Planar cell polarity signaling in collective cell movements during morphogenesis and disease. Curr Genomics (2012) 0.91
Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies. J Gastroenterol (2011) 0.90
Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes. J Virol (2012) 0.90
Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells. Exp Cell Res (2011) 0.89
Crosstalk between beta-catenin and snail in the induction of epithelial to mesenchymal transition in hepatocarcinoma: role of the ERK1/2 pathway. Int J Mol Sci (2013) 0.89
Frizzled homolog proteins, microRNAs and Wnt signaling in cancer. Int J Cancer (2012) 0.89
Therapeutic potential of targeting glypican-3 in hepatocellular carcinoma. Anticancer Agents Med Chem (2011) 0.89
Functional consequences of WNT3/Frizzled7-mediated signaling in non-transformed hepatic cells. Oncogenesis (2012) 0.88
Molecular mechanisms underlying hepatocellular carcinoma. Viruses (2009) 0.87
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis. Oncogene (2011) 0.87
Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. PLoS One (2012) 0.86
FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. Cell Death Dis (2014) 0.85
Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS One (2012) 0.85
Stage of breast cancer progression influences cellular response to activation of the WNT/planar cell polarity pathway. Sci Rep (2014) 0.83
Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. Gastrointest Cancer Res (2007) 0.83
Analysis of cellular changes resulting from forced expression of Dickkopf-1 in hepatocellular carcinoma cells. Cancer Res Treat (2007) 0.83
Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1. Can J Gastroenterol Hepatol (2015) 0.82
Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma. Lab Invest (2015) 0.82
Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies. World J Hepatol (2012) 0.81
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cell Mol Gastroenterol Hepatol (2015) 0.80
FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer. BMB Rep (2015) 0.79
Comparison of the regulation of β-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells. PLoS One (2012) 0.79
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances. F1000Res (2016) 0.78
Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity. Liver Int (2013) 0.78
Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer. Cancers (Basel) (2016) 0.78
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem (2015) 0.78
Anti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines. Drug Des Devel Ther (2013) 0.77
Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett (2015) 0.77
Aberrant regulation of Wnt signaling in hepatocellular carcinoma. World J Gastroenterol (2016) 0.76
Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation. Cancer Biol Ther (2016) 0.76
Frizzled-7 promoter is highly active in tumors and promoter-driven Shiga-like toxin I inhibits hepatocellular carcinoma growth. Oncotarget (2015) 0.75
Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells. Oncol Lett (2016) 0.75
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers. Cancers (Basel) (2016) 0.75
FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Oncotarget (2017) 0.75
Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology (2002) 9.35
Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology (2002) 5.48
Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer. Gastrointest Endosc (2006) 5.42
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol (2011) 5.39
Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A (2002) 4.52
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis (2005) 3.78
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology (2010) 3.55
Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study. Circulation (2012) 3.53
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis (2009) 3.45
Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology (2004) 3.19
Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer. Int J Clin Oncol (2015) 2.70
Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection. Am J Gastroenterol (2005) 2.62
Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer (2010) 2.20
Endoscopic prediction of deep submucosal invasive carcinoma: validation of the narrow-band imaging international colorectal endoscopic (NICE) classification. Gastrointest Endosc (2013) 2.16
Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection. Gastrointest Endosc (2012) 2.12
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis (2005) 2.12
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis (2005) 2.11
Validation of a simple classification system for endoscopic diagnosis of small colorectal polyps using narrow-band imaging. Gastroenterology (2012) 2.11
Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal disease patients. Nephrol Dial Transplant (2009) 2.09
Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc (2008) 2.09
Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes. Hepatol Res (2007) 2.07
Magnifying endoscopy with narrow band imaging for diagnosis of colorectal tumors. Gastrointest Endosc (2007) 2.04
Genetic polymorphisms and esophageal cancer risk. Int J Cancer (2007) 2.02
Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol (2008) 1.97
Subunit arrangement in P2X receptors. J Neurosci (2003) 1.93
Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors. Gastrointest Endosc (2009) 1.92
Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy. Gastrointest Endosc (2007) 1.87
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis (2006) 1.82
Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells. J Hepatol (2003) 1.80
Transcriptional repressor snail and progression of human hepatocellular carcinoma. Clin Cancer Res (2003) 1.79
Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res (2010) 1.77
Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma. J Clin Gastroenterol (2003) 1.76
Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection. J Gastroenterol Hepatol (2012) 1.72
Characteristics of patients with chronic hepatitis B in France: predominant frequency of HBe antigen negative cases. J Hepatol (2006) 1.72
The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res (2008) 1.71
Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: epidemiologic and biomolecular study. J Gastroenterol Hepatol (2006) 1.70
Risk factors for delayed bleeding after endoscopic submucosal dissection for colorectal neoplasms. Int J Colorectal Dis (2014) 1.70
The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One (2013) 1.69
Angioplasty for chronic total occlusion by using tapered-tip guidewires. Catheter Cardiovasc Interv (2003) 1.68
Improved visibility of lesions of the small intestine via capsule endoscopy with computed virtual chromoendoscopy. Gastrointest Endosc (2011) 1.67
Multiple carcinoid tumors of the ileum preoperatively diagnosed by enteroscopy with the double-balloon technique. Gastrointest Endosc (2005) 1.67
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimers Dis (2006) 1.65
Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology (2006) 1.64
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection. J Hepatol (2010) 1.63
Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy. Gastrointest Endosc (2007) 1.62
Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer (2003) 1.60
Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res (2004) 1.58
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol (2008) 1.56
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice. J Hepatol (2010) 1.56
Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus. J Med Virol (2008) 1.51
Feasibility and efficacy of high-dose three-dimensional-conformal radiotherapy in cirrhotic patients with small-size hepatocellular carcinoma non-eligible for curative therapies--mature results of the French Phase II RTF-1 trial. Int J Radiat Oncol Biol Phys (2006) 1.51
Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci (2006) 1.50
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis (2006) 1.48
Impact of highly active antiretroviral therapy (HAART) on the natural history of hepatitis B virus (HBV) and HIV coinfection: relationship between prolonged efficacy of HAART and HBV surface and early antigen seroconversion. Clin Infect Dis (2007) 1.47
New method to increase a backup support of a 6 French guiding coronary catheter. Catheter Cardiovasc Interv (2004) 1.47
Frequent somatic mutations of mitochondrial DNA in traditional serrated adenomas but not in sessile serrated adenomas of the colorectum. J Gastroenterol Hepatol (2011) 1.47
Large-scale analysis of the GRAS gene family in Arabidopsis thaliana. Plant Mol Biol (2008) 1.46
Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int J Cancer (2002) 1.46
Current status of endoscopic resection strategy for large, early colorectal neoplasia in Japan. Surg Endosc (2013) 1.45
Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol (2003) 1.44
Coronary intervention with 4-French catheters. Catheter Cardiovasc Interv (2010) 1.44
Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology (2006) 1.44
Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese. Helicobacter (2011) 1.43
Usefulness of EUS with double-balloon enteroscopy for diagnosis of small-bowel diseases. Gastrointest Endosc (2007) 1.42
Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci (2004) 1.41
Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs. J Hepatol (2013) 1.40
Comparison of detectability of small-bowel lesions between capsule endoscopy and double-balloon endoscopy for patients with suspected small-bowel disease. Gastrointest Endosc (2009) 1.39
Current status in the occurrence of postoperative bleeding, perforation and residual/local recurrence during colonoscopic treatment in Japan. Dig Endosc (2010) 1.38
Expression of uncoupling protein-2 in human colon cancer. Clin Cancer Res (2004) 1.37
Long-term outcome of acute myocardial infarction patients treated with stents versus balloon angioplasty: results from randomized trials. Int J Cardiol (2008) 1.37
Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem (2003) 1.35
Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer (2009) 1.34
Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis. Scand J Gastroenterol (2010) 1.34
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors. J Biol Chem (2003) 1.34
Clinical outcomes of endoscopic submucosal dissection and endoscopic mucosal resection for laterally spreading tumors larger than 20 mm. J Gastroenterol Hepatol (2012) 1.34
Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. J Hepatol (2005) 1.33
Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis. Oncology (2008) 1.33
Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Cancer (2003) 1.32
Evaluation of microvessels in colorectal tumors by narrow band imaging magnification. Gastrointest Endosc (2007) 1.32
Defensive medicine practices among gastroenterologists in Japan. World J Gastroenterol (2006) 1.31
Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment. Clin Cancer Res (2005) 1.31
Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality. Gastroenterology (2006) 1.31
Acute ethanol exposure inhibits insulin signaling in the liver. Hepatology (2007) 1.31
The human cervical cancer oncogene protein is a biomarker for human hepatocellular carcinoma. Cancer Res (2004) 1.30
Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology (2005) 1.30
Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing. Small (2008) 1.29
Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol (2003) 1.29
Insulin resistance in experimental alcohol-induced liver disease. J Gastroenterol Hepatol (2008) 1.28
Prevention of hepatocellular carcinoma. N Engl J Med (2004) 1.27
Private genome analysis through homomorphic encryption. BMC Med Inform Decis Mak (2015) 1.27
Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study. Gastrointest Endosc (2009) 1.26