PubRank

John A Martignetti

Author PubWeight™ 62.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 2008 4.03
2 Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology 2004 2.29
3 Liver transplantation for hepatocellular carcinoma: extension of indications based on molecular markers. J Hepatol 2008 2.22
4 A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 2005 2.02
5 Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J Hepatol 2006 1.98
6 Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003 1.86
7 Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. Cancer Res 2005 1.65
8 Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. Gastroenterology 2004 1.59
9 Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet 2007 1.56
10 A critical re-appraisal of BRCA1 methylation studies in ovarian cancer. Gynecol Oncol 2010 1.56
11 Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination. Clin Cancer Res 2006 1.51
12 The first report of homozygous May-Hegglin anomaly E1841K mutation. Eur J Haematol 2011 1.46
13 KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. J Clin Invest 2008 1.36
14 Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. J Immunol 2009 1.36
15 Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. Gastroenterology 2008 1.21
16 Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. Cancer Res 2005 1.20
17 Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma. Int J Cancer 2007 1.17
18 The role of KLF6 and its splice variants in cancer therapy. Drug Resist Updat 2008 1.13
19 A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response. Cancer Res 2008 1.12
20 Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors. EMBO Mol Med 2011 1.08
21 Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. Oncogene 2004 1.02
22 KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model. Cancer Res 2009 1.00
23 Nucleo-cytoplasmic localization domains regulate Krüppel-like factor 6 (KLF6) protein stability and tumor suppressor function. PLoS One 2010 0.99
24 Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. Blood 2011 0.97
25 A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA Cell Biol 2003 0.96
26 Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression. J Ovarian Res 2011 0.95
27 Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts. Am J Hum Genet 2012 0.93
28 Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer. Eur J Cancer 2008 0.93
29 Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression. Dig Dis Sci 2010 0.93
30 Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. Am J Hum Genet 2012 0.91
31 STK11 domain XI mutations: candidate genetic drivers leading to the development of dysplastic polyps in Peutz-Jeghers syndrome. Hum Mutat 2014 0.90
32 Infantile systemic hyalinosis: Case report and review of the literature. J Am Acad Dermatol 2008 0.89
33 Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. Hum Mutat 2009 0.88
34 A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects. Eur J Hum Genet 2008 0.88
35 Juvenile hyaline fibromatosis and infantile systemic hyalinosis overlap associated with a novel mutation in capillary morphogenesis protein-2 gene. Am J Dermatopathol 2007 0.87
36 The Krüppel traffic report: cooperative signals direct KLF8 nuclear transport. Cell Res 2009 0.86
37 Krüppel cripples prostate cancer: KLF6 progress and prospects. Am J Pathol 2003 0.86
38 Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. J Biol Chem 2012 0.86
39 KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma. Int J Cancer 2007 0.86
40 Functional role of the KLF6 tumour suppressor gene in gastric cancer. Eur J Cancer 2008 0.85
41 Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. FASEB J 2012 0.84
42 KLF6 is one transcription factor involved in regulating acid ceramidase gene expression. Biochim Biophys Acta 2006 0.83
43 Systemic hyalinosis: a distinctive early childhood-onset disorder characterized by mutations in the anthrax toxin receptor 2 gene (ANTRX2). Pediatrics 2006 0.83
44 A study of TRAIL receptors in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2005 0.82
45 Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. Am J Hum Genet 2013 0.82
46 Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones. Carcinogenesis 2005 0.82
47 First successful use of eltrombopag before surgery in a child with MYH9-related thrombocytopenia. Pediatrics 2013 0.81
48 Multicentric osteolysis with nodulosis and arthropathy (MONA) with cardiac malformation, mimicking polyarticular juvenile idiopathic arthritis: case report and literature review. Eur J Pediatr 2013 0.81
49 Torg-Winchester syndrome: lack of efficacy of pamidronate therapy. Clin Dysmorphol 2007 0.80
50 Loss of MMP-2 in murine osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis. Dis Model Mech 2012 0.79
51 Application of RNA-Seq transcriptome analysis: CD151 is an Invasion/Migration target in all stages of epithelial ovarian cancer. J Ovarian Res 2012 0.79
52 MYH9 spectrum of autosomal-dominant giant platelet syndromes: unexpected association with fibulin-1 variant-D inactivation. Am J Hematol 2003 0.77
53 Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment. Mt Sinai J Med 2009 0.77
54 IGFBP-4 tumor and serum levels are increased across all stages of epithelial ovarian cancer. J Ovarian Res 2012 0.77
55 Bladder exstrophy and Epstein type congenital macrothrombocytopenia: evidence for a common cause? Am J Med Genet A 2006 0.76
56 A new feature of the MYH9-related syndrome: chronic transaminase elevation. Hepatology 2012 0.75