Published in Vaccine on November 25, 2004
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol (2009) 2.25
Conditional immortalization of human B cells by CD40 ligation. PLoS One (2008) 1.89
Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Immunology (2008) 0.98
Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands. Clin Vaccine Immunol (2007) 0.96
Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates. Nucleic Acids Res (2006) 0.92
Nuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonists. BMC Biotechnol (2011) 0.86
Immunomodulatory oligonucleotides inhibit neutrophil migration by decreasing the surface expression of interleukin-8 and leukotriene B4 receptors. Immunology (2015) 0.78
A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells. Immunology (2006) 0.77
Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use. J Immunol Res (2015) 0.75
B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids. J Immunol (2017) 0.75
PD-L1 expression on tolerogenic APCs is controlled by STAT-3. Eur J Immunol (2011) 2.80
Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection. Stroke (2009) 2.28
Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem (2004) 1.86
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol (2007) 1.53
Immunostimulatory CpG-DNA activates murine microglia. J Immunol (2002) 1.52
QuantiFERON TB-Gold--a new test strengthening long-suspected tuberculous involvement in serpiginous-like choroiditis. Am J Ophthalmol (2008) 1.48
Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology (2007) 1.38
The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation. Stroke (2009) 1.38
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol (2004) 1.35
Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology (2005) 1.34
Activation of toll-like receptor 9 by DNA from different bacterial species. Infect Immun (2006) 1.29
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol (2006) 1.27
Quantitative detection of periodontopathogens by real-time PCR. J Microbiol Methods (2004) 1.26
Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet (2011) 1.26
Modifications in small interfering RNA that separate immunostimulation from RNA interference. J Immunol (2008) 1.22
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease. J Cyst Fibros (2011) 1.20
Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol (2004) 1.18
TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol Immunol (2007) 1.08
DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells. Infect Immun (2003) 1.05
The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. J Allergy Clin Immunol (2008) 1.03
Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction. J Immunol (2009) 1.03
Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo. Immunology (2002) 1.03
Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter. EMBO Rep (2004) 1.01
Molecular characterization of a respiratory syncytial virus outbreak in a hematology unit in Heidelberg, Germany. J Clin Microbiol (2012) 1.00
Real-time polymerase chain reaction for detection and quantification of bacteria in periodontal patients. J Periodontol (2005) 1.00
Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology (2007) 0.98
Triggering of Toll-like receptors modulates IFN-gamma signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling. Eur J Immunol (2003) 0.98
TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity. Vaccine (2003) 0.97
Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. J Immunol (2008) 0.95
Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation. Blood (2006) 0.93
Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B. J Immunol (2012) 0.92
Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J (2008) 0.90
Surveillance of siRNA integrity by FRET imaging. Nucleic Acids Res (2007) 0.90
Structural requirements for uptake and recognition of CpG oligonucleotides. Int J Med Microbiol (2007) 0.89
Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells. Immunobiology (2002) 0.89
CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections. Int J Med Microbiol (2007) 0.88
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J Immunol (2008) 0.88
Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. J Virol (2002) 0.87
Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles. J Immunol (2012) 0.87
Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus. J Immunol (2013) 0.87
Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria. J Periodontal Res (2006) 0.87
Signal integration following Toll-like receptor triggering. Crit Rev Immunol (2002) 0.87
Reduced efficacy of circulating costimulatory cells after focal cerebral ischemia. Stroke (2011) 0.86
Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent. Infect Immun (2010) 0.85
Hematoma size as major modulator of the cellular immune system after experimental intracerebral hemorrhage. Neurosci Lett (2010) 0.84
Micromonas (Peptostreptococcus) micros: unusual case of prosthetic joint infection associated with dental procedures. Int J Med Microbiol (2005) 0.84
Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway. Circ Res (2005) 0.84
Usefulness of serum procalcitonin levels for the early diagnosis of stroke-associated respiratory tract infections. Neurocrit Care (2011) 0.84
The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression. Mol Cancer (2010) 0.83
Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling. Cell Commun Signal (2012) 0.83
Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells. Eur J Immunol (2014) 0.83
Immunopharmacology of CpG DNA. Biol Chem (2002) 0.83
Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases. PLoS One (2013) 0.82
Synergistic and antagonistic interactions between LPS and superantigens. J Endotoxin Res (2003) 0.82
Antineoplastic effect of immunostimulatory DNA (CpG-ODN) in a murine C57-BL6/MB-49 transitional cell carcinoma model. Anticancer Res (2004) 0.82
Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity. Cell Microbiol (2010) 0.82
CpG DNA in the prevention and treatment of infections. BioDrugs (2002) 0.82
In vitro and in vivo effects of CpG-Oligodeoxynucleotides (CpG-ODN) on murine transitional cell carcinoma and on the native murine urinary bladder wall. Anticancer Res (2009) 0.82
Bifunctional oligodeoxynucleotide/antagomiR constructs: evaluation of a new tool for microRNA silencing. Nucleic Acid Ther (2013) 0.82
Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes. PLoS One (2012) 0.81
Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages. J Biol Chem (2012) 0.80
CpG-DNA as immune response modifier. Int J Med Microbiol (2004) 0.80
Low risk of apparent transmission of vancomycin-resistant Enterococci from bacteraemic patients to hospitalized contacts. Am J Infect Control (2013) 0.80
Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3' sequence modifications. Vaccine (2003) 0.80
Possible risk for re-colonization with methicillin-resistant Staphylococcus aureus (MRSA) by faecal transmission. Int J Hyg Environ Health (2005) 0.80
IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. Eur J Immunol (2013) 0.80
Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction. Int J Med Microbiol (2013) 0.79
Effects of caspofungin, Candida albicans and Aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs. FEMS Immunol Med Microbiol (2010) 0.79
Immunostimulatory CpG oligonucleotides form defined three-dimensional structures: results from an NMR study. ChemMedChem (2007) 0.79
Continuous blood pressure measurement using the pulse transit time: Comparison to intra-arterial measurement. Blood Press (2015) 0.77
CpG oligonucleotides with modified termini and nicked dumbbell structure show enhanced immunostimulatory activity. J Med Chem (2003) 0.77
PDC expressing CD36, CD61 and IL-10 may contribute to propagation of immune tolerance. Autoimmunity (2009) 0.76
Suppressors of cytokine signaling proteins in innate and adaptive immune responses. Arch Immunol Ther Exp (Warsz) (2003) 0.76
Varicella-like cutaneous toxoplasmosis in a patient with aplastic anemia. J Clin Microbiol (2013) 0.75
Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision. Immunology (2013) 0.75
A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae. Cerebrovasc Dis (2017) 0.75
Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns. Environ Sci Pollut Res Int (2010) 0.75