Published in Immunity on November 01, 2004
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity (2008) 5.82
Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 4.17
TLRs and innate immunity. Blood (2008) 3.96
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 3.70
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58
Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity (2008) 3.48
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med (2006) 2.41
Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci (2008) 2.39
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood (2006) 2.35
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med (2010) 2.35
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest (2006) 2.17
Mechanisms maintaining peripheral tolerance. Nat Immunol (2009) 2.14
Residual immune dysregulation syndrome in treated HIV infection. Adv Immunol (2013) 2.01
Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment. Immunity (2011) 1.98
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun (2006) 1.92
Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One (2008) 1.83
The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity (2011) 1.70
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood (2008) 1.69
Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunol Rev (2008) 1.64
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int (2013) 1.60
Toll or toll-free adjuvant path toward the optimal vaccine development. J Clin Immunol (2007) 1.58
Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity. Br J Cancer (2006) 1.50
Strategies for selective priming of memory B cells. Immunol Lett (2007) 1.47
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. J Immunol (2008) 1.47
Duodenal expression of Toll-like receptors and interleukins are increased in both children and adult celiac patients. Dig Dis Sci (2012) 1.45
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines. J Clin Invest (2006) 1.41
Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest (2009) 1.35
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. Am J Pathol (2009) 1.30
Beneficial effects of Bacteroides fragilis polysaccharides on the immune system. Front Biosci (Landmark Ed) (2010) 1.27
TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol (2009) 1.26
The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus. J Immunol (2009) 1.24
Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J Neuroimmunol (2008) 1.24
Innate control of B cell responses. Trends Immunol (2011) 1.21
Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J (2008) 1.19
Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity (2014) 1.16
Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology (2007) 1.16
Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. J Immunol (2008) 1.14
Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12
MyD88 intrinsically regulates CD4 T-cell responses. J Virol (2008) 1.11
Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10
The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun (2008) 1.10
Human dendritic cell subsets for vaccination. J Clin Immunol (2005) 1.09
Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun (2009) 1.08
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance. Immunology (2009) 1.06
Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol (2006) 1.06
Ubiquitin in the immune system. EMBO Rep (2013) 1.06
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med (2006) 1.06
TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol (2010) 1.05
Modulation of innate immune responses with synthetic lipid A derivatives. J Am Chem Soc (2007) 1.05
Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. EMBO J (2006) 1.03
Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. J Clin Invest (2011) 1.01
Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification. Endocr Metab Immune Disord Drug Targets (2009) 1.01
Innate receptors and microbes in induction of autoimmunity. Curr Opin Immunol (2009) 1.00
Poly(I:C) and lipopolysaccharide innate sensing functions of circulating human myeloid dendritic cells are affected in vivo in hepatitis C virus-infected patients. J Virol (2007) 1.00
Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog (2013) 0.99
Effect of barrier microbes on organ-based inflammation. J Allergy Clin Immunol (2013) 0.97
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. Arthritis Res Ther (2005) 0.97
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest (2015) 0.97
Understanding how lipopolysaccharide impacts CD4 T-cell immunity. Crit Rev Immunol (2008) 0.96
Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii. Clin Exp Immunol (2009) 0.96
TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion. PLoS One (2013) 0.96
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B. J Immunol (2011) 0.95
Corticosterone impairs dendritic cell maturation and function. Immunology (2007) 0.95
Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis. Prostate (2007) 0.94
Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. AIDS Res Hum Retroviruses (2007) 0.94
T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife (2014) 0.92
Dealing with Danger in the CNS: The Response of the Immune System to Injury. Neuron (2015) 0.91
IL-6 promotes cardiac graft rejection mediated by CD4+ cells. J Immunol (2011) 0.89
Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol (2008) 0.89
HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retroviruses (2012) 0.89
CD4+CD25+ T regulatory cells induced by LPS-activated bone marrow dendritic cells suppress experimental autoimmune uveoretinitis in vivo. Graefes Arch Clin Exp Ophthalmol (2007) 0.89
In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS One (2010) 0.88
Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis. Semin Arthritis Rheum (2008) 0.88
Generation and maintenance of human memory cells during viral infection. Springer Semin Immunopathol (2006) 0.87
Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A (2014) 0.86
Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivo. J Immunol (2014) 0.85
The role of mucosal T lymphocytes in regulating intestinal inflammation. Springer Semin Immunopathol (2005) 0.85
Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev (Orlando) (2011) 0.85
Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells. J Immunol (2007) 0.85
In vitro atrazine exposure affects the phenotypic and functional maturation of dendritic cells. Toxicol Appl Pharmacol (2007) 0.84
Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease. Arterioscler Thromb Vasc Biol (2012) 0.84
Chemical synthesis and proinflammatory responses of monophosphoryl lipid A adjuvant candidates. European J Org Chem (2010) 0.84
Pulmonary endotoxin tolerance protects against cockroach allergen-induced asthma-like inflammation in a mouse model. Int Arch Allergy Immunol (2012) 0.84
Regulatory T cells: present facts and future hopes. Med Microbiol Immunol (2006) 0.83
Structure-based design of novel human Toll-like receptor 8 agonists. ChemMedChem (2014) 0.83
Regulation of frontline antibody responses by innate immune signals. Immunol Res (2012) 0.81
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol (2013) 0.81
Targeting lentiviral vectors for cancer immunotherapy. Curr Cancer Ther Rev (2011) 0.80
A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics. Inflammopharmacology (2012) 0.80
Oral vaccination with attenuated Salmonella enterica strains encoding T-cell epitopes from tumor antigen NY-ESO-1 induces specific cytotoxic T-lymphocyte responses. Clin Vaccine Immunol (2010) 0.80
Endogenous CD4+ CD25+ regulatory T cells play no apparent role in the acute humoral response to intact Streptococcus pneumoniae. Infect Immun (2005) 0.79
Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin-10 in cervical neoplastic lesions. Immunology (2015) 0.79
TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB. Front Immunol (2014) 0.78
Role of Toll-like receptors in host responses to a virulence antigen of Streptococcus mutans expressed by a recombinant, attenuated Salmonella vector vaccine. Vaccine (2010) 0.78
Prior stimulation of antigen-presenting cells with Lactobacillus regulates excessive antigen-specific cytokine responses in vitro when compared with Bacteroides. Cytotechnology (2007) 0.78
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34
Type I interferons in host defense. Immunity (2006) 7.32
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Toll-like receptor signaling pathways. Science (2003) 5.86
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54
Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98
Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11
Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90
Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65
Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43
Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38
Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30
Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11
Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09
Allergic host defences. Nature (2012) 1.99
Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88
Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79
Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62
Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62
Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57
Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56
Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52
The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48
Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40
Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38
Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36
Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35
Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34
Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33
Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27
Evolution of inflammatory diseases. Curr Biol (2012) 1.27
Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21
Learning tolerance while fighting ignorance. Cell (2009) 1.20
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14
Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10
Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10
Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10
Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08
Innate sensors of microbial infection. J Clin Immunol (2005) 1.05
Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05
The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01
Two modes of ligand recognition by TLRs. Cell (2007) 0.99
Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97
Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94
Antifungal defense turns 17. Nat Immunol (2007) 0.93
Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90
Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89
Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89
A new shield for a cytokine storm. Cell (2011) 0.88
graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85
The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84
Skin antibiotics get in the loop. Nat Med (2002) 0.84
Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82
Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82
A plague on host defense. J Exp Med (2002) 0.81
T helper 17 cells get the NOD. Immunity (2007) 0.78
Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78
Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76
Innovating immunology: an interview with Ruslan Medzhitov. Dis Model Mech (2011) 0.75
Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75