PubRank

Oliver Smithies

Author PubWeight™ 92.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 2006 4.10
2 Mouse models of diabetic nephropathy. J Am Soc Nephrol 2009 3.74
3 Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 2005 2.59
4 Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell 2004 2.52
5 Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002 2.45
6 Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest 2006 2.33
7 Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A 2002 2.08
8 Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol 2004 1.71
9 Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension 2007 1.70
10 Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension 2006 1.62
11 Impaired T cell function in RANTES-deficient mice. Clin Immunol 2002 1.60
12 Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest 2007 1.53
13 Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proc Natl Acad Sci U S A 2006 1.48
14 Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A 2004 1.45
15 Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 2006 1.38
16 Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol 2006 1.35
17 Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A 2007 1.30
18 Three-dimensional diffusion tensor microscopy of fixed mouse hearts. Magn Reson Med 2004 1.28
19 Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proc Natl Acad Sci U S A 2010 1.26
20 Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest 2006 1.22
21 Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc Natl Acad Sci U S A 2004 1.21
22 RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A 2009 1.21
23 Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol 2007 1.18
24 Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. J Biol Chem 2007 1.18
25 Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. J Am Soc Nephrol 2002 1.16
26 Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology 2005 1.16
27 A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A 2002 1.15
28 Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin. PLoS One 2009 1.14
29 Targeted disruption of hsp70.1 sensitizes to osmotic stress. EMBO Rep 2002 1.13
30 A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proc Natl Acad Sci U S A 2006 1.13
31 Kidney function in mice lacking aldosterone. Am J Physiol Renal Physiol 2005 1.11
32 A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A 2011 1.10
33 Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. J Mol Endocrinol 2007 1.06
34 Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. Am J Physiol Renal Physiol 2003 1.05
35 eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. J Am Soc Nephrol 2012 1.05
36 The kallikrein-kinin system in health and in diseases of the kidney. Kidney Int 2009 1.04
37 Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A 2010 1.03
38 Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol 2008 1.03
39 Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. Horm Behav 2002 1.02
40 Altering the expression in mice of genes by modifying their 3' regions. Dev Cell 2004 1.00
41 Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A 2005 1.00
42 Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. Endocrinology 2003 0.99
43 Amino acids as modulators of endothelium-derived nitric oxide. Am J Physiol Renal Physiol 2006 0.94
44 Physiological impact of increased expression of the AT1 angiotensin receptor. Hypertension 2003 0.94
45 Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2002 0.93
46 Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proc Natl Acad Sci U S A 2007 0.92
47 Lifelong genetic minipumps. Physiol Genomics 2004 0.92
48 E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. J Immunol 2004 0.91
49 The kallikrein-kinin system in diabetic nephropathy. Kidney Int 2012 0.90
50 Isolating gene-corrected stem cells without drug selection. Proc Natl Acad Sci U S A 2005 0.90
51 Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A 2008 0.90
52 Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J Clin Invest 2002 0.90
53 Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. J Biol Chem 2006 0.88
54 Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. Genomics 2004 0.88
55 Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Surgery 2003 0.88
56 Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochim Biophys Acta 2009 0.87
57 β-MyHC and cardiac hypertrophy: size does matter. Circ Res 2011 0.86
58 A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics 2004 0.86
59 Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression. Gene Expr 2010 0.85
60 Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proc Natl Acad Sci U S A 2009 0.84
61 Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. Proc Natl Acad Sci U S A 2013 0.83
62 The kallikrein-kinin system and oxidative stress. Curr Opin Nephrol Hypertens 2012 0.83
63 Human genetics, animal models and computer simulations for studying hypertension. Trends Genet 2004 0.82
64 Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. Endocrinology 2010 0.82
65 An improved technique for tail-cuff blood pressure measurements with dark-tailed mice. Contemp Top Lab Anim Sci 2005 0.81
66 Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. Am J Physiol Renal Physiol 2012 0.81
67 Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene. Cardiovasc Res 2005 0.81
68 Science brick by brick. Nature 2010 0.80
69 Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. FASEB J 2010 0.80
70 Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression. Gene Expr 2012 0.79
71 Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. J Immunol 2010 0.79
72 Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. Eur J Heart Fail 2009 0.78
73 Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proc Natl Acad Sci U S A 2011 0.78
74 Gender-dependent survival of allogeneic trophoblast stem cells in liver. Cell Transplant 2009 0.78
75 Multiple roles of adrenomedullin revealed by animal models. Microsc Res Tech 2002 0.77
76 Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility. Methods Mol Biol 2012 0.77
77 The role of transforming growth factor β1 in the regulation of blood pressure. Curr Hypertens Rev 2014 0.75
78 Transforming growth factor beta1 and aldosterone. Curr Opin Nephrol Hypertens 2015 0.75
79 Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells. Exp Hematol 2010 0.75
80 Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera. J Clin Hypertens (Greenwich) 2008 0.75
81 An interview with... Oliver Smithies [interviewed by Magdalena Skipper]. Nat Rev Genet 2005 0.75
82 A conversation with Oliver Smithies. J Clin Invest 2015 0.75
83 The whole of a scientific career: an interview with Oliver Smithies. PLoS Genet 2015 0.75