Thyroid status, disability and cognitive function, and survival in old age.

PubWeight™: 5.39‹?› | Rank: Top 1%

🔗 View Article (PMID 15572717)

Published in JAMA on December 01, 2004

Authors

Jacobijn Gussekloo1, Eric van Exel, Anton J M de Craen, Arend E Meinders, Marijke Frölich, Rudi G J Westendorp

Author Affiliations

1: Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. jgussekloo@lumc.nl

Articles citing this

(truncated to the top 100)

Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20

Thyroid status, cardiovascular risk, and mortality in older adults. JAMA (2006) 3.50

Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77

Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med (2012) 2.24

Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ (2009) 2.11

Thyroid status and 6-year mortality in elderly people living in a mildly iodine-deficient area: the aging in the Chianti Area Study. J Am Geriatr Soc (2013) 2.10

Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. J Clin Endocrinol Metab (2009) 2.04

Subclinical hypothyroidism and functional mobility in older adults. Arch Intern Med (2009) 1.91

2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J (2013) 1.87

Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation (2012) 1.79

Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study. J Clin Endocrinol Metab (2012) 1.75

Extreme longevity is associated with increased serum thyrotropin. J Clin Endocrinol Metab (2009) 1.66

Autoimmune thyroiditis as a risk factor for stroke: a historical cohort study. Neurology (2014) 1.46

Subclinical hypothyroidism: an update for primary care physicians. Mayo Clin Proc (2009) 1.45

Mild cognitive impairment and dementia: the importance of modifiable risk factors. Dtsch Arztebl Int (2011) 1.43

Thyroid function and the risk of Alzheimer disease: the Framingham Study. Arch Intern Med (2008) 1.40

Impact of thyroid status and age on comprehensive geriatric assessment. Endocrine (2013) 1.39

Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc (2008) 1.37

The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study. J Clin Endocrinol Metab (2012) 1.33

Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr) (2012) 1.33

Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.25

Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J (2011) 1.18

Hormonal regulation of longevity in mammals. Ageing Res Rev (2007) 1.15

Management of subclinical hypothyroidism: the thyroidologists' view. Eur Thyroid J (2012) 1.09

High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over. J Clin Endocrinol Metab (2009) 1.08

Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study. J Clin Endocrinol Metab (2012) 1.08

Thyroid disease in the oldest old: the exception to the rule. JAMA (2004) 1.02

Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques. Thyroid Res (2011) 1.02

Treatment for primary hypothyroidism: current approaches and future possibilities. Drug Des Devel Ther (2011) 1.02

A review of the evidence for and against increased mortality in hypothyroidism. Nat Rev Endocrinol (2012) 1.01

Thyroid function and mortality in older men: a prospective study. J Clin Endocrinol Metab (2012) 1.01

Hypothyroidism in the elderly: diagnosis and management. Clin Interv Aging (2012) 1.00

Polypharmacy and excessive polypharmacy in octogenarians and older acutely hospitalized patients. Wien Klin Wochenschr (2014) 0.99

Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul) (2014) 0.98

The Dilemma of Treating Subclinical Hypothyroidism: Risk that Current Guidelines Do More Harm than Good. Eur Thyroid J (2014) 0.98

Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab (2015) 0.96

Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH). BMC Public Health (2010) 0.94

Serum leptin, thyroxine and thyroid-stimulating hormone levels interact to affect cognitive function among US adults: evidence from a large representative survey. Neurobiol Aging (2011) 0.94

Thyroid hormones are associated with cognitive function: moderation by sex, race, and depressive symptoms. J Clin Endocrinol Metab (2013) 0.93

Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort. J Clin Endocrinol Metab (2007) 0.93

Subclinical hypothyroidism: Controversies to consensus. Indian J Endocrinol Metab (2013) 0.93

Subclinical thyroid dysfunction and cognitive decline in old age. PLoS One (2013) 0.93

Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA (2015) 0.92

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Sci Rep (2015) 0.92

Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes (2014) 0.92

Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts. JAMA Intern Med (2015) 0.92

International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. Br J Gen Pract (2015) 0.91

Identification of differentially expressed thyroid hormone responsive genes from the brain of the Mexican Axolotl (Ambystoma mexicanum). Comp Biochem Physiol C Toxicol Pharmacol (2011) 0.91

The TSH upper reference limit: where are we at? Nat Rev Endocrinol (2011) 0.90

Subclinical hypothyroidism and survival: the effects of heart failure and race. J Clin Endocrinol Metab (2013) 0.90

Hypothyroidism and depression. Eur Thyroid J (2013) 0.90

Hypothyroidism and mortality among dialysis patients. Clin J Am Soc Nephrol (2012) 0.90

Thyroid function in the euthyroid range and adverse outcomes in older adults. J Clin Endocrinol Metab (2014) 0.90

Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins. J Clin Endocrinol Metab (2013) 0.89

Thyroid Function and Cognition during Aging. Curr Gerontol Geriatr Res (2008) 0.89

Age and the thyrotropin response to hypothyroxinemia. J Clin Endocrinol Metab (2010) 0.89

The prevalence of thyroid dysfunction in elderly cardiology patients with mild excessive iodine intake in the urban area of São Paulo. Clinics (Sao Paulo) (2009) 0.89

Thyroid hormones and cognitive functioning in healthy, euthyroid women: a correlational study. Horm Behav (2012) 0.88

Genetics of thyroid function and disease. Clin Biochem Rev (2011) 0.88

Thyroid stimulating hormone, cognitive impairment and depression in an older korean population. Psychiatry Investig (2010) 0.87

Subclinical hypothyroidism, mood, and cognition in older adults: a review. Int J Geriatr Psychiatry (2012) 0.87

The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being. BMC Geriatr (2010) 0.87

Predictors of thyroid hormone initiation in older adults: results from the cardiovascular health study. J Gerontol A Biol Sci Med Sci (2011) 0.87

A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians' relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity. Age Ageing (2010) 0.86

Clinical review: The thyroid in mind: cognitive function and low thyrotropin in older people. J Clin Endocrinol Metab (2012) 0.85

Thyroid dysfunction in the elderly. Nat Rev Endocrinol (2013) 0.85

Thyroid hormones association with depression severity and clinical outcome in patients with major depressive disorder. Mol Biol Rep (2014) 0.83

Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis. Eur J Epidemiol (2014) 0.82

Levothyroxine Substitution in Patients with Subclinical Hypothyroidism and the Risk of Myocardial Infarction and Mortality. PLoS One (2015) 0.82

Frequency of dementia syndromes with a potentially treatable cause in geriatric in-patients: analysis of a 1-year interval. Eur Arch Psychiatry Clin Neurosci (2015) 0.82

Mildly elevated TSH and cognition in middle-aged and older adults. Thyroid (2009) 0.82

Thyroid and aging or the aging thyroid? An evidence-based analysis of the literature. J Thyroid Res (2013) 0.82

Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. Eur Arch Psychiatry Clin Neurosci (2014) 0.82

Subclinical Hypothyroidism and Cardiovascular Disease. Endocrinol Metab (Seoul) (2015) 0.82

Hypothyroidism and risk of mild cognitive impairment in elderly persons: a population-based study. JAMA Neurol (2014) 0.81

Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study. J Clin Endocrinol Metab (2016) 0.81

Duration of thyroid dysfunction correlates with all-cause mortality. the OPENTHYRO Register Cohort. PLoS One (2014) 0.81

Thyroid hormones are associated with longitudinal cognitive change in an urban adult population. Neurobiol Aging (2015) 0.81

Mild thyroid hormone excess is associated with a decreased physical function in elderly men. Aging Male (2011) 0.81

Endothelial Functioning and Hemodynamic Parameters in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement. PLoS One (2015) 0.80

Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid (2013) 0.80

The association of thyroid stimulating hormone levels with cognitive function and depressed mood: the Rancho Bernardo study. J Nutr Health Aging (2009) 0.80

Predictors for mortality in hospitalized patients with chronic obstructive pulmonary disease. Springerplus (2014) 0.80

Association between increased serum thyrotropin concentration and the oldest old: what do we know? Einstein (Sao Paulo) (2015) 0.79

Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis. Front Aging Neurosci (2015) 0.79

Free Thyroxine and Functional Mobility, Fitness, and Fatigue in Euthyroid Older Men and Women in the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci (2016) 0.79

Reference interval of thyroid stimulating hormone and free thyroxine in a reference population over 60 years old and in very old subjects (over 80 years): comparison to young subjects. Thyroid Res (2013) 0.79

Changes in pituitary function with ageing and implications for patient care. Nat Rev Endocrinol (2013) 0.79

TSH - Clinical Aspects of its Use in Determining Thyroid Disease in the Elderly. How Does it Impact the Practice of Medicine in Aging? Adv Pharmacoepidemiol Drug Saf (2012) 0.78

Cardiovascular risk and quality of life in elderly people with mild thyroid hormone deficiency. Front Endocrinol (Lausanne) (2014) 0.78

Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: study protocol for a randomized controlled trial. Trials (2013) 0.78

Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis. J Endocrinol Invest (2017) 0.77

Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther Adv Endocrinol Metab (2016) 0.77

Are hsCRP Levels and LDL/HDL Ratio Better and Early Markers to Unmask Onset of Dyslipidemia and Inflammation in Asymptomatic Subclinical Hypothyroidism? Indian J Clin Biochem (2012) 0.77

Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls. Environ Health Perspect (2015) 0.77

Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study. Clin Interv Aging (2016) 0.77

(Healthy) ageing: focus on iodothyronines. Int J Mol Sci (2013) 0.76

Clinical Update in Aspects of the Management of Autoimmune Thyroid Diseases. Endocrinol Metab (Seoul) (2016) 0.76

Prevalence of Subclinical Hypothyroidism among Patients with Acute Myocardial Infarction. ISRN Endocrinol (2011) 0.76

Management of thyroid disorders. Postgrad Med J (2006) 0.76

Articles by these authors

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet (2002) 17.19

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet (2010) 14.24

Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87

Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87

Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. J Am Coll Cardiol (2008) 3.43

Measuring cognitive function with age: the influence of selection by health and survival. Epidemiology (2008) 3.19

Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study. Arch Intern Med (2008) 2.90

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet (2006) 2.89

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell (2005) 2.83

Predicting survival in oldest old people. Am J Med (2012) 2.81

Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol (2005) 2.81

No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study. Crit Care Med (2002) 2.79

Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study. BMJ (2009) 2.46

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37

Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology (2005) 2.30

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30

External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. J Natl Cancer Inst (2014) 2.26

Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med (2012) 2.24

Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. J Clin Epidemiol (2008) 2.20

Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. J Am Soc Nephrol (2005) 2.16

Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13

Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ (2009) 2.11

Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old. Stroke (2013) 2.10

In a population-based prospective study, no association between high blood pressure and mortality after age 85 years. J Hypertens (2006) 2.04

Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ (2010) 2.03

Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. JAMA (2012) 2.00

Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol (2005) 1.93

Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc (2007) 1.91

Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet (2007) 1.85

Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing (2010) 1.79

Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation (2012) 1.79

Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study. Diabetes (2002) 1.75

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72

High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study. J Am Geriatr Soc (2012) 1.70

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J Gerontol A Biol Sci Med Sci (2009) 1.70

Serum calcium and cognitive function in old age. J Am Geriatr Soc (2007) 1.66

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol (2007) 1.62

Screening for cognitive impairment in older general hospital patients: comparison of the Six-Item Cognitive Impairment Test with the Mini-Mental State Examination. Int J Geriatr Psychiatry (2011) 1.61

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A (2010) 1.60

Adipocytokines and risk of stroke in older people: a nested case-control study. Int J Epidemiol (2008) 1.59

The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes. Int J Epidemiol (2011) 1.58

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? PLoS Med (2009) 1.54

Predictive value of a profile of routine blood measurements on mortality in older persons in the general population: the Leiden 85-plus Study. PLoS One (2013) 1.53

Genes encoding longevity: from model organisms to humans. Aging Cell (2008) 1.53

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet (2013) 1.52

Aspirin use after diagnosis improves survival in older adults with colon cancer: a retrospective cohort study. J Am Geriatr Soc (2012) 1.51

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. Clin Nutr (2011) 1.50

Old age mortality and macroeconomic cycles. J Epidemiol Community Health (2013) 1.48

Pravastatin and cognitive function in the elderly. Results of the PROSPER study. J Neurol (2009) 1.47

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Heart (2010) 1.46

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45

C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Circulation (2007) 1.43

Hallmark features of immunosenescence are absent in familial longevity. J Immunol (2010) 1.43

N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Ann Neurol (2014) 1.41

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J Gerontol A Biol Sci Med Sci (2006) 1.39

Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population. J Am Geriatr Soc (2002) 1.39

Temporal relation between depression and cognitive impairment in old age: prospective population based study. BMJ (2004) 1.37

Central obesity is an independent risk factor for albuminuria in nondiabetic South Asian subjects. Diabetes Care (2007) 1.36

The controversies of statin therapy: weighing the evidence. J Am Coll Cardiol (2012) 1.36

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study. J Am Geriatr Soc (2010) 1.33

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33

Familial longevity is marked by enhanced insulin sensitivity. Aging Cell (2010) 1.32