Published in Nat Med on December 19, 2004
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Impaired daily glucocorticoid rhythm in Per1 ( Brd ) mice. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2006) 1.06
Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. Addict Biol (2011) 1.05
Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse. Alcohol Clin Exp Res (2010) 1.05
Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster. Am J Physiol Regul Integr Comp Physiol (2009) 1.03
Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster. Pharmacol Biochem Behav (2007) 1.03
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Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. Addict Biol (2012) 1.02
Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. Psychopharmacology (Berl) (2006) 1.01
Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. J Neurosci (2010) 1.01
Role of intestinal circadian genes in alcohol-induced gut leakiness. Alcohol Clin Exp Res (2011) 1.00
Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res (2011) 0.98
Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice. Chronobiol Int (2011) 0.97
When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr Opin Neurobiol (2011) 0.97
A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Transl Psychiatry (2012) 0.96
Clock genes running amok. Clock genes and their role in drug addiction and depression. EMBO Rep (2007) 0.96
Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology (Berl) (2009) 0.96
The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents. Ups J Med Sci (2010) 0.95
Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. Diabetes (2012) 0.95
The circadian clock and mood-related behavior. Commun Integr Biol (2008) 0.94
Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology (2012) 0.93
Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior. Eur J Neurosci (2012) 0.93
PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents. Biol Psychiatry (2011) 0.93
Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One (2009) 0.93
Clock gene variants in mood and anxiety disorders. J Neural Transm (Vienna) (2012) 0.93
An essential role for adenosine signaling in alcohol abuse. Curr Drug Abuse Rev (2010) 0.92
Glial cell modulation of circadian rhythms. Glia (2010) 0.91
An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype. Psychiatry Res (2013) 0.90
Period 2 gene deletion abolishes beta-endorphin neuronal response to ethanol. Alcohol Clin Exp Res (2010) 0.90
Acamprosate reduces ethanol drinking behaviors and alters the metabolite profile in mice lacking ENT1. Neurosci Lett (2010) 0.90
The Role of Glial Cells in Drug Abuse. Curr Drug Abuse Rev (2009) 0.90
Evening types are more often current smokers and nicotine-dependent-a study of Finnish adult twins. Addiction (2010) 0.90
Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcohol Clin Exp Res (2008) 0.89
Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biol Psychiatry (2014) 0.88
Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption. Pharmacol Biochem Behav (2012) 0.88
Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure. Alcohol Clin Exp Res (2010) 0.88
Association of PER2 genotype and stressful life events with alcohol drinking in young adults. PLoS One (2013) 0.88
Circadian rhythms and addiction: mechanistic insights and future directions. Behav Neurosci (2014) 0.87
Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate. Transl Psychiatry (2014) 0.87
Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One (2013) 0.87
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Selective breeding for ethanol-related traits alters circadian phenotype. Alcohol (2013) 0.86
Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology (2012) 0.86
CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. J Circadian Rhythms (2010) 0.85
Effects of alcohol on the endocrine system. Endocrinol Metab Clin North Am (2013) 0.85
The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels. Behav Brain Res (2013) 0.85
Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats. J Psychopharmacol (2008) 0.84
The role of clock in ethanol-related behaviors. Neuropsychopharmacology (2013) 0.84
The Molecular Circadian Clock and Alcohol-Induced Liver Injury. Biomolecules (2015) 0.84
The circadian clock, reward, and memory. Front Mol Neurosci (2011) 0.83
Diversity of human clock genotypes and consequences. Prog Mol Biol Transl Sci (2013) 0.83
Mammalian molecular clocks. Exp Neurobiol (2011) 0.83
Ethanol consumption in mice: relationships with circadian period and entrainment. Alcohol (2010) 0.83
Molecular mechanisms underlying alcohol-drinking behaviours. Nat Rev Neurosci (2016) 0.83
Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Am J Physiol Gastrointest Liver Physiol (2013) 0.83
Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings. Behav Brain Res (2008) 0.83
Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice. PLoS One (2013) 0.83
Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1. Neurosci Lett (2010) 0.83
Sleep and circadian contributions to adolescent alcohol use disorder. Alcohol (2014) 0.83
Modeling and validating chronic pharmacological manipulation of circadian rhythms. CPT Pharmacometrics Syst Pharmacol (2013) 0.83
Chronobiology of alcohol: studies in C57BL/6J and DBA/2J inbred mice. Physiol Behav (2013) 0.82
Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol. Alcohol Res (2013) 0.82
Circadian genes differentially affect tolerance to ethanol in Drosophila. Alcohol Clin Exp Res (2013) 0.82
Larval ethanol exposure alters free-running circadian rhythm and per Locus transcription in adult D. melanogaster period mutants. Behav Brain Res (2012) 0.82
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav Brain Sci (2011) 14.12
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Mucosal flora in inflammatory bowel disease. Gastroenterology (2002) 8.42
Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A (2003) 7.64
Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology (2006) 6.88
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet (2009) 6.21
Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut (2011) 6.08
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med (2005) 5.36
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet (2005) 5.35
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation (2008) 5.20
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet (2006) 4.72
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet (2009) 4.63
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet (2007) 4.61
Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med (2012) 4.41
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38
Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology (2004) 4.26
Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet (2005) 4.23
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology (2002) 4.20
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med (2007) 4.07
Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A (2009) 4.02
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet (2008) 3.99
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. Brain (2009) 3.96
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet (2008) 3.95
Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med (2008) 3.90
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Nod2 is essential for temporal development of intestinal microbial communities. Gut (2011) 3.69
Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci (2004) 3.56
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature (2011) 3.53
Genetic structure of Europeans: a view from the North-East. PLoS One (2009) 3.46
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. PLoS Genet (2010) 3.39
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology (2007) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet (2010) 3.22
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet (2004) 3.19
A comprehensive evaluation of SNP genotype imputation. Hum Genet (2008) 3.18
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18