Ethnicity and human genetic linkage maps.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMC 1196373)

Published in Am J Hum Genet on December 30, 2004


Eric Jorgenson1, Hua Tang, Maya Gadde, Mike Province, Mark Leppert, Sharon Kardia, Nicholas Schork, Richard Cooper, D C Rao, Eric Boerwinkle, Neil Risch

Author Affiliations

1: Department of Genetics, Stanford University, Stanford, CA, USA.

Associated clinical trials:

Family Blood Pressure Program - GenNet Network | NCT00005268

Family Blood Pressure Program - HyperGEN | NCT00005267

Family Blood Pressure Program - GENOA | NCT00005269

Family Blood Pressure Program - SAPPHIRe Network | NCT00005270

Articles citing this

The landscape of recombination in African Americans. Nature (2011) 3.06

Why do human diversity levels vary at a megabase scale? Genome Res (2005) 2.33

Coverage and power in genomewide association studies. Am J Hum Genet (2006) 1.53

Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41

Large-scale recombination rate patterns are conserved among human populations. Genome Res (2005) 1.17

Meiotic recombination in human oocytes. PLoS Genet (2009) 1.15

The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Res (2012) 1.14

Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res (2010) 1.09

A dense linkage map for Chinook salmon (Oncorhynchus tshawytscha) reveals variable chromosomal divergence after an ancestral whole genome duplication event. G3 (Bethesda) (2014) 1.05

The ambiguous meanings of the racial/ethnic categories routinely used in human genetics research. Soc Sci Med (2007) 1.04

Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS One (2013) 0.92

The synaptonemal complex and meiotic recombination in humans: new approaches to old questions. Chromosoma (2006) 0.92

A genome-wide Asian genetic map and ethnic comparison: the GENDISCAN study. BMC Genomics (2008) 0.90

Genetic crossovers are predicted accurately by the computed human recombination map. PLoS Genet (2010) 0.90

Examining variation in recombination levels in the human female: a test of the production-line hypothesis. Am J Hum Genet (2014) 0.88

Examination of a region showing linkage map discrepancies across sheep breeds. Mamm Genome (2006) 0.87

Comparative mapping between Coho Salmon (Oncorhynchus kisutch) and three other salmonids suggests a role for chromosomal rearrangements in the retention of duplicated regions following a whole genome duplication event. G3 (Bethesda) (2014) 0.85

Racial and Socioeconomic Variation in Genetic Markers of Telomere Length: A Cross-Sectional Study of U.S. Older Adults. EBioMedicine (2016) 0.84

Accommodating chromosome inversions in linkage analysis. Am J Hum Genet (2006) 0.83

Sex-specific genetic architecture of human fatness in Chinese: the SAPPHIRe Study. Hum Genet (2010) 0.83

The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability. J Mol Med (Berl) (2006) 0.83

Variation in patterns of human meiotic recombination. Genome Dyn (2009) 0.80

Family physicians' beliefs about genetic contributions to racial/ethnic and gender differences in health and clinical decision-making. Community Genet (2008) 0.79

Expression differences by continent of origin point to the immortalization process. Hum Mol Genet (2009) 0.79

Ethnicity may be a reason for lipid changes and high Lp(a) levels in rheumatoid arthritis. Clin Rheumatol (2006) 0.78

Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women. Reprod Sci (2008) 0.77

Enhanced genetic maps from family-based disease studies: population-specific comparisons. BMC Med Genet (2011) 0.76

Admixture provides new insights into recombination. Nat Genet (2011) 0.75

Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice. Am J Hum Genet (2015) 0.75

Articles cited by this

A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66

Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet (1998) 19.35

A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34

Comparison of human genetic and sequence-based physical maps. Nature (2001) 4.97

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51

Chromosome choreography: the meiotic ballet. Science (2003) 4.00

Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements. Am J Hum Genet (2001) 3.57

Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP). Hypertension (2002) 3.32

High-resolution patterns of meiotic recombination across the human major histocompatibility complex. Am J Hum Genet (2002) 2.71

Covariation of synaptonemal complex length and mammalian meiotic exchange rates. Science (2002) 2.54

Chromosome-wide control of meiotic crossing over in C. elegans. Curr Biol (2003) 2.38

Short tandem repeat polymorphism evolution in humans. Eur J Hum Genet (1998) 2.30

Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains. Genetics (2002) 1.90

Patterns of meiotic recombination in human fetal oocytes. Am J Hum Genet (2002) 1.59

Complex low-copy repeats associated with a common polymorphic inversion at human chromosome 8p23. Genomics (2003) 1.38

A 37-marker PCR-based genetic linkage map of human chromosome 9: observations on mutations and positive interference. Genomics (1995) 1.25

Articles by these authors

The structure of haplotype blocks in the human genome. Science (2002) 50.88

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Worldwide human relationships inferred from genome-wide patterns of variation. Science (2008) 22.44

Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00

A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Replicating genotype-phenotype associations. Nature (2007) 16.11

A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78

Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet (2003) 13.60

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61

Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med (2003) 7.94

Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59

A mapping function for man. Hum Hered (1977) 7.50

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16

Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry (2011) 6.98

dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions. Hum Mutat (2011) 6.97

Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

Analysis of family resemblance. II. A linear model for familial correlation. Am J Hum Genet (1974) 6.51

Reconstructing genetic ancestry blocks in admixed individuals. Am J Hum Genet (2006) 5.92

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89

Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol (2010) 5.79

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

A unified model for complex segregation analysis. Am J Hum Genet (1983) 5.67

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med (2002) 5.52

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Genomewide association studies of stroke. N Engl J Med (2009) 5.29

dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations. Hum Mutat (2013) 5.11

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest (2008) 5.05

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

Categorization of humans in biomedical research: genes, race and disease. Genome Biol (2002) 4.84

Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78

Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78

Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation (2011) 4.78

Generalized T2 test for genome association studies. Am J Hum Genet (2002) 4.55

Clan genomics and the complex architecture of human disease. Cell (2011) 4.53

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51

Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science (2003) 4.48

Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

A maximum likelihood map of chromosome 1. Am J Hum Genet (1979) 4.34

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28

An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study. Arch Intern Med (2006) 4.23

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation (2003) 3.94

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med (2006) 3.90

Molecular and evolutionary history of melanism in North American gray wolves. Science (2009) 3.87

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2003) 3.75

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet (2009) 3.60

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55

A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet (2002) 3.52

Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research. Am J Public Health (2005) 3.50

Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol (2007) 3.48

The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet Epidemiol (2010) 3.48

Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet (2004) 3.47

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol (2008) 3.43

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A (2005) 3.37

The amyloidogenic V122I transthyretin variant in elderly black Americans. N Engl J Med (2015) 3.36

Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33

Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol (2004) 3.25

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

The transmission of schizophrenia under a multifactorial threshold model. Am J Hum Genet (1983) 3.24

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

NHLBI Family Heart Study: objectives and design. Am J Epidemiol (1996) 3.21

Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. J Comp Neurol (2004) 3.20

Population stratification confounds genetic association studies among Latinos. Hum Genet (2005) 3.19

NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet (2009) 3.18