Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

PubWeight™: 1.73‹?› | Rank: Top 3%

🔗 View Article (PMID 15633128)

Published in Gastroenterology on January 01, 2005

Authors

Fiona Oakley1, Muriel Meso, John P Iredale, Karen Green, Carylyn J Marek, Xiaoying Zhou, Michael J May, Harry Millward-Sadler, Matthew C Wright, Derek A Mann

Author Affiliations

1: Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK.

Associated clinical trials:

Anti-Fibrotic Effects of Losartan In Nash Evaluation Study (FELINE) | NCT01051219

Articles citing this

Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28

Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol (2010) 3.30

NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2011) 3.28

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58

Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med (2012) 2.28

Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology (2009) 1.73

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology (2013) 1.40

Current status of novel antifibrotic therapies in patients with chronic liver disease. Therap Adv Gastroenterol (2011) 1.34

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Mol Pharmacol (2008) 1.31

Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl) (2008) 1.27

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol (2006) 1.24

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol (2008) 1.23

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol (2009) 1.17

Advances in antifibrotic therapy. Expert Rev Gastroenterol Hepatol (2008) 1.17

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology (2009) 1.15

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death Dis (2011) 1.03

Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol (2008) 1.02

Pathogenesis of liver cirrhosis. World J Gastroenterol (2014) 0.99

Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models. Front Immunol (2013) 0.99

Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gastroenterol (2012) 0.99

Cell penetrating peptide inhibitors of nuclear factor-kappa B. Cell Mol Life Sci (2008) 0.95

Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res (2007) 0.94

Specific siRNA targeting the receptor for advanced glycation end products inhibits experimental hepatic fibrosis in rats. Int J Mol Sci (2008) 0.90

Use of mesenchymal stem cells to treat liver fibrosis: current situation and future prospects. World J Gastroenterol (2015) 0.89

Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists. Biologics (2014) 0.88

Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut (2006) 0.88

The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol (2010) 0.88

Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells. Adv Pharmacol Sci (2014) 0.86

Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway. Sci Rep (2015) 0.85

Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics. Comp Hepatol (2009) 0.85

Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model. Exp Mol Med (2012) 0.83

Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis. J Physiol (2016) 0.81

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis. Sci Rep (2016) 0.81

MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells. Sci Rep (2015) 0.81

18α-Glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells. Med Sci Monit (2012) 0.81

Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy. Hepatol Int (2008) 0.81

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One (2016) 0.80

Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth. J Biol Chem (2014) 0.80

Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver. World J Gastroenterol (2006) 0.79

Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis. PLoS One (2011) 0.78

Portal hypertension as immune mediate disease. Hepat Mon (2014) 0.78

Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. Gut (2005) 0.78

Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells. PLoS One (2014) 0.78

Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling. Biomed Res Int (2016) 0.77

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy. PLoS One (2015) 0.77

Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition. Hepatol Res (2010) 0.77

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling. Drug Des Devel Ther (2015) 0.77

Liver inflammation and fibrosis. J Clin Invest (2017) 0.77

A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. J Hepatol (2016) 0.76

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res (2014) 0.76

A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration. Mol Biosyst (2016) 0.76

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun (2016) 0.76

Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production. Oncotarget (2016) 0.75

Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury. Drug Des Devel Ther (2016) 0.75

Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway. PLoS One (2017) 0.75

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther (2017) 0.75

A20 Attenuates Liver Fibrosis in NAFLD and Inhibits Inflammation Responses. Inflammation (2017) 0.75

Articles by these authors

Identification of severe acute respiratory syndrome in Canada. N Engl J Med (2003) 14.29

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG (2011) 8.32

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell (2002) 5.84

Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature (2007) 4.68

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96

An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med (2002) 3.39

Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A (2008) 2.99

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94

Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem (2002) 2.88

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol (2008) 2.83

Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A (2006) 2.75

Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol (2007) 2.64

Predicting antimicrobial resistance in invasive pneumococcal infections. Clin Infect Dis (2005) 2.59

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A (2012) 2.54

The bone marrow functionally contributes to liver fibrosis. Gastroenterology (2006) 2.52

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Hepatology (2012) 2.52

Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology (2004) 2.44

Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A (2010) 2.43

Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med (2012) 2.28

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology (2011) 2.27

Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res (2004) 2.25

Association between cirrhosis and Helicobacter pylori infection: a meta-analysis. Eur J Gastroenterol Hepatol (2014) 2.17

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology (2009) 2.17

Clinical evidence for the regression of liver fibrosis. J Hepatol (2012) 2.16

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Am J Respir Crit Care Med (2011) 2.15

SARS among critical care nurses, Toronto. Emerg Infect Dis (2004) 2.10

Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res (2006) 1.97

Liver fibrosis. Biochem J (2008) 1.97

Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. J Allergy Clin Immunol (2008) 1.93

Severe group a streptococcal soft-tissue infections in Ontario: 1992-1996. Clin Infect Dis (2002) 1.93

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88

Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology (2009) 1.84

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Clin Cancer Res (2004) 1.83

Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci (Lond) (2007) 1.77

Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis (2003) 1.76

Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology (2007) 1.74

A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host Microbe (2011) 1.70

Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int (2004) 1.69

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology (2011) 1.65

RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem (2003) 1.63

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem Cell Res (2010) 1.62

Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital. Infect Control Hosp Epidemiol (2005) 1.61

Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. J Biol Chem (2004) 1.59

A highly homozygous and parthenogenetic human embryonic stem cell line derived from a one-pronuclear oocyte following in vitro fertilization procedure. Cell Res (2007) 1.58

Modeling liver fibrosis in rodents. Methods Mol Med (2005) 1.57

Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J (2002) 1.56

Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol (2005) 1.53

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Hepatology (2014) 1.52

Hepatic changes in the failing Fontan circulation. Heart (2006) 1.48

Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae. BMC Genomics (2009) 1.47

Possible SARS coronavirus transmission during cardiopulmonary resuscitation. Emerg Infect Dis (2004) 1.45

Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease. Nat Med (2011) 1.45

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut (2010) 1.44

Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. Mol Microbiol (2009) 1.44

The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res (2008) 1.43

Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood (2007) 1.42

The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J Hepatol (2010) 1.37

Self-collected mid-turbinate swabs for the detection of respiratory viruses in adults with acute respiratory illnesses. PLoS One (2011) 1.33

Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. J Immunol (2008) 1.32

Progress and future challenges in stem cell-derived liver technologies. Am J Physiol Gastrointest Liver Physiol (2009) 1.32

Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. Matrix Biol (2003) 1.32

In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002. Antimicrob Agents Chemother (2004) 1.30

Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol (2002) 1.28

Developing high-fidelity hepatotoxicity models from pluripotent stem cells. Stem Cells Transl Med (2013) 1.27

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol (2006) 1.24

Total polyphenolic (flavonoids) content and antioxidant capacity of different Ziziphora clinopodioides Lam. extracts. Pharmacogn Mag (2011) 1.24

Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol (2011) 1.24

Effect of hard-drug use on CD4 cell percentage, HIV RNA level, and progression to AIDS-defining class C events among HIV-infected women. J Acquir Immune Defic Syndr (2004) 1.22

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines. Stroke (2008) 1.20

Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. Pediatr Res (2007) 1.20

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci U S A (2013) 1.20

Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis. J Biol Chem (2008) 1.20

Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct (2004) 1.18

Insulin pump therapy: guidelines for successful outcomes. Diabetes Educ (2009) 1.18

Reversal of fibrosis: no longer a pipe dream? Clin Liver Dis (2006) 1.18

Persistence of functional hepatocyte-like cells in immune-compromised mice. Liver Int (2010) 1.18

Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells. Cancer Biol Ther (2009) 1.17

Effect of patterns of transferring patients among healthcare institutions on rates of nosocomial methicillin-resistant Staphylococcus aureus transmission: a Monte Carlo simulation. Infect Control Hosp Epidemiol (2011) 1.17

Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies. Mol Interv (2002) 1.16

Reversibility of liver fibrosis. Ann Hepatol (2009) 1.16

Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology (2005) 1.15

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells. J Biol Chem (2003) 1.14

Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J Biol Chem (2003) 1.13

Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer (2010) 1.13

Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury. J Hepatol (2008) 1.13

NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (2008) 1.12

Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1. Int J Biochem Cell Biol (2004) 1.12

Multiple plant surface signals are sensed by different mechanisms in the rice blast fungus for appressorium formation. PLoS Pathog (2011) 1.12