Published in Cancer Cell on January 01, 2005
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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
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Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol Cell Biol (2007) 1.62
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol Cancer (2009) 1.62
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Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet (2005) 1.61
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Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One (2009) 1.52
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Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med (2011) 1.51
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Reactive oxygen species and cellular oxygen sensing. Free Radic Biol Med (2007) 1.49
Clinical aspects of SDHx-related pheochromocytoma and paraganglioma. Endocr Relat Cancer (2009) 1.48
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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab (2015) 1.46
Targeting glycogen metabolism in bladder cancer. Nat Rev Urol (2015) 1.46
Altered metabolism and mitochondrial genome in prostate cancer. J Clin Pathol (2006) 1.45
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The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency. BMC Med Genet (2008) 1.38
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36
Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate. J Am Chem Soc (2011) 1.36
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol (2013) 1.35
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet (2010) 1.34
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Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics. Fam Cancer (2011) 1.30
Mitochondrial DNA instability and metabolic shift in human cancers. Int J Mol Sci (2009) 1.29
Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun (2013) 1.29
Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines. PLoS One (2009) 1.28
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells. Cell Cycle (2010) 1.27
HIF and fumarate hydratase in renal cancer. Br J Cancer (2007) 1.27
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol (2011) 1.26
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer (2011) 1.25
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Defects in mitochondrial metabolism and cancer. Cancer Metab (2014) 1.24
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
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Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature (2012) 8.66
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84
The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol (2005) 6.18
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16
Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08
Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96
Targeting metabolic transformation for cancer therapy. Nat Rev Cancer (2010) 5.90
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol (2004) 5.31
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev (2006) 5.15
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
Necrotic death as a cell fate. Genes Dev (2006) 4.93
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell (2008) 4.84
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94
Akt-dependent transformation: there is more to growth than just surviving. Oncogene (2005) 3.91
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Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev (2003) 3.79
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell (2006) 3.66
Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol (2011) 3.65
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell (2004) 3.62
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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol (2002) 3.58
Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
ATP citrate lyase is an important component of cell growth and transformation. Oncogene (2005) 3.48
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem (2006) 3.45
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res (2007) 3.35
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol (2007) 3.33
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24
Metabolic enzymes as oncogenes or tumor suppressors. N Engl J Med (2009) 3.24
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
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Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell (2012) 2.82
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem (2003) 2.80
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev (2004) 2.77