Published in J Immunol on February 15, 2005
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2009) 4.90
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med (2006) 3.20
Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 2.08
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol (2008) 1.99
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med (2008) 1.63
How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A (2005) 1.55
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest (2006) 1.52
Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol (2008) 1.38
Control of central and peripheral tolerance by Aire. Immunol Rev (2011) 1.37
Aire and T cell development. Curr Opin Immunol (2010) 1.36
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A (2007) 1.31
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med (2010) 1.27
Contrasting models of promiscuous gene expression by thymic epithelium. J Exp Med (2005) 1.24
Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci (2008) 1.20
AIRE in the thymus and beyond. Curr Opin Immunol (2009) 1.16
Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED. J Clin Immunol (2008) 1.16
AIRE regulates T-cell-independent B-cell responses through BAFF. Proc Natl Acad Sci U S A (2008) 1.13
AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet (2009) 1.13
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol (2009) 1.13
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis (2009) 1.12
Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A (2008) 1.12
Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol (2007) 1.07
Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res (2013) 1.06
Ubiquitin in the immune system. EMBO Rep (2013) 1.06
The role of AIRE in human autoimmune disease. Nat Rev Endocrinol (2010) 1.00
NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. J Biol Chem (2006) 0.98
The role of the thymus in tolerance. Transplantation (2010) 0.95
The thymus microenvironment in regulating thymocyte differentiation. Cell Adh Migr (2010) 0.93
An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse. J Immunol (2010) 0.92
The role of Aire in clonal selection. Immunol Cell Biol (2010) 0.90
The many faces of aire in central tolerance. Front Immunol (2013) 0.90
Direct and indirect roles of the LTbetaR pathway in central tolerance induction. Trends Immunol (2010) 0.89
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A (2010) 0.88
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription. Nucleic Acids Res (2011) 0.88
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88
The ambiguity in immunology. Front Immunol (2012) 0.87
Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage. Immunity (2016) 0.87
Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. Clin Exp Immunol (2008) 0.86
AIRE expands: new roles in immune tolerance and beyond. Nat Rev Immunol (2016) 0.86
Shaping the repertoire of tumor-infiltrating effector and regulatory T cells. Immunol Rev (2014) 0.85
Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis. Proc Natl Acad Sci U S A (2011) 0.85
Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clin Exp Immunol (2013) 0.85
Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases. J Clin Invest (2016) 0.83
Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model? Front Immunol (2013) 0.83
Human APECED; a Sick Thymus Syndrome? Front Immunol (2013) 0.82
Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus. Nat Commun (2016) 0.82
Transplant tolerance: new insights and strategies for long-term allograft acceptance. Clin Dev Immunol (2013) 0.80
Models of aire-dependent gene regulation for thymic negative selection. Front Immunol (2011) 0.80
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. J Neuroimmunol (2011) 0.80
Mechanisms and models of immune tolerance breakdown in the ovary. Semin Reprod Med (2011) 0.80
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Nat Commun (2016) 0.80
Why Aire? Compensating for late bloomers. Eur J Immunol (2009) 0.79
Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. Immunogenetics (2006) 0.79
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. J Immunol (2013) 0.79
Insights into type 1 diabetes from the autoimmune polyendocrine syndromes. Curr Opin Endocrinol Diabetes Obes (2013) 0.79
Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants. Comput Struct Biotechnol J (2014) 0.78
Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype. J Immunol (2014) 0.78
Association of AIRE polymorphisms with genetic susceptibility to rheumatoid arthritis in a Chinese population. Inflammation (2014) 0.77
Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN mice. PLoS One (2013) 0.77
APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility Factors. Front Immunol (2013) 0.77
Central tolerance to self revealed by the autoimmune regulator. Ann N Y Acad Sci (2015) 0.76
ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression. PLoS One (2010) 0.76
Monogenic autoimmune diseases: insights into self-tolerance. Pediatr Res (2009) 0.75
Role of viruses and bacteria-virus interactions in autoimmunity. Curr Opin Immunol (2014) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Regulatory T cells and immune tolerance. Cell (2008) 18.77
CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev (2002) 10.54
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev (2006) 10.24
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity (2009) 9.01
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
Regulatory T cells in transplantation tolerance. Nat Rev Immunol (2003) 6.42
A promoter-level mammalian expression atlas. Nature (2014) 6.25
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med (2007) 5.58
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2009) 4.90
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med (2004) 4.77
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol (2004) 4.59
Regulatory T cells in tumor immunity. Int J Cancer (2010) 4.53
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature (2003) 4.22
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol (2005) 3.95
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol (2003) 3.42
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A (2008) 3.40
Natural regulatory T cells: mechanisms of suppression. Trends Mol Med (2007) 3.37
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med (2007) 3.29
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Regulation of CD8+ T cell development by thymus-specific proteasomes. Science (2007) 3.11
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity (2004) 3.10
The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature (2007) 3.01
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol (2006) 2.93
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med (2005) 2.80
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity (2012) 2.78
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood (2006) 2.72
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Development and maintenance of regulatory T cells. Immunity (2013) 2.61
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol (2002) 2.57
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity (2007) 2.57
CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med (2004) 2.52
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med (2005) 2.51
P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res (2004) 2.48
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A (2013) 2.47
Effects of epinephrine and vasopressin on cerebral microcirculatory flows during and after cardiopulmonary resuscitation. Crit Care Med (2007) 2.47
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol (2004) 2.40
Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol (2003) 2.28
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature (2006) 2.16
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest (2004) 2.16
Preserved cerebral microcirculation during cardiogenic shock. Crit Care Med (2009) 2.14
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity (2006) 2.12
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.11
Free radicals mediate postshock contractile impairment in cardiomyocytes. Crit Care Med (2008) 2.09
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity (2009) 2.05
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.04
Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J (2007) 1.96
IAN family critically regulates survival and development of T lymphocytes. PLoS Biol (2006) 1.95
Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci (2008) 1.95
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity (2012) 1.94
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol (2004) 1.92