Published in J Immunol on February 15, 2005
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Protective immune mechanisms in helminth infection. Nat Rev Immunol (2007) 5.66
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med (2006) 4.11
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol (2014) 1.86
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A (2006) 1.54
The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response. J Immunol (2007) 1.25
Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites. Int J Parasitol (2008) 1.11
Infection with parasitic nematodes confounds vaccination efficacy. Vet Parasitol (2007) 1.10
Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms. Infect Immun (2009) 1.07
Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. J Immunol (2008) 1.00
Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol (2009) 0.92
Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways. J Immunol (2011) 0.89
A new mechanism for inhalational priming: IL-4 bypasses innate immune signals. J Immunol (2008) 0.89
Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths. Mucosal Immunol (2014) 0.84
IL-18 stimulates IL-13-mediated IFN-gamma-sensitive host resistance in vivo. Eur J Immunol (2006) 0.81
IL-9 and Th9 in parasite immunity. Semin Immunopathol (2016) 0.75
Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling. Sci Rep (2017) 0.75
Negative Regulation of Type 2 Immunity. Trends Immunol (2017) 0.75
Interleukin-2: inception, impact, and implications. Science (1988) 8.19
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
IL-4 directs the development of Th2-like helper effectors. J Immunol (1990) 7.20
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
Helper T cell differentiation is controlled by the cell cycle. Immunity (1998) 5.71
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol (1999) 4.97
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity (2004) 4.81
Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol (2000) 4.73
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol (2004) 4.62
Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. Proc Natl Acad Sci U S A (1984) 4.62
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med (2004) 4.45
IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol (1992) 4.43
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med (1995) 4.21
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 3.98
Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature (1995) 3.84
Transcriptional regulation of the IL-2 gene. Curr Opin Immunol (1995) 3.14
IL-2, regulatory T cells, and tolerance. J Immunol (2004) 3.13
Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol (2004) 3.08
Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J Immunol (1991) 3.04
Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med (2000) 2.99
Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci U S A (2004) 2.98
The IL-2 receptor complex: its structure, function, and target genes. Annu Rev Immunol (1993) 2.96
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med (2004) 2.57
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 2.52
Helper T cells regulate type-2 innate immunity in vivo. Nature (2002) 2.47
Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med (1992) 2.37
Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc Natl Acad Sci U S A (1998) 2.26
Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J Exp Med (1999) 2.09
Stat6 regulation of in vivo IL-4 responses. J Immunol (2000) 1.97
Resistance to Leishmania major induced by tolerance to a single antigen. Science (1996) 1.87
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J Exp Med (1994) 1.76
The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol (2003) 1.57
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med (1994) 1.54
Production of BSF-1 during an in vivo, T-dependent immune response. J Immunol (1986) 1.47
A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells. J Immunol (1994) 1.41
Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. J Immunol (2000) 1.31
Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol (1995) 1.30
IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation. Eur J Immunol (2002) 1.26
Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol (2002) 1.26
Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol Rev (2004) 1.24
Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4. J Immunol (2001) 1.22
Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. J Immunol (2000) 1.20
Critical role of interleukin-2 in the development of acute graft-versus-host disease. Int Immunol (1993) 1.12
Th1/Th2 effector choice in parasitic infection: decision making by committee. Curr Opin Immunol (2001) 1.07
Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med (2003) 1.04
Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J Immunol (2002) 1.02
IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol (2004) 1.00
CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters. Proc Natl Acad Sci U S A (2004) 0.96
Instruction, selection, or tampering with the odds? Science (1999) 0.95
Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response. J Immunol (1995) 0.93
Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. J Immunol (2002) 0.84
Characterization of a relatively rare class B, type 2 trypanosome variant surface glycoprotein gene. J Parasitol (1998) 0.78
A proteomic view of the Plasmodium falciparum life cycle. Nature (2002) 10.65
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53
Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol (2005) 6.47
Protective immune mechanisms in helminth infection. Nat Rev Immunol (2007) 5.66
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell (2010) 5.28
Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology (2005) 5.26
A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res (2004) 5.21
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature (2010) 5.07
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med (2004) 4.45
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol (2004) 4.41
Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med (2006) 4.16
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev (2004) 3.63
Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am J Gastroenterol (2003) 3.40
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther (2008) 2.96
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med (2012) 2.60
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol (2007) 2.50
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain. Science (2010) 2.47
Alternatively activated macrophages in helminth infections. Curr Opin Immunol (2007) 2.41
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (2004) 2.35
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med (2007) 2.33
Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol (2002) 2.28
Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol (2003) 2.27
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24
Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway. J Exp Med (2011) 2.20
IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med (2008) 2.19
Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest (2003) 2.17
Unique maturation program of the IgE response in vivo. Immunity (2007) 2.15
The immune response to parasitic helminths: insights from murine models. Trends Immunol (2003) 2.14
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology (2008) 2.09
Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog (2009) 2.07
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol (2005) 1.98
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med (2009) 1.97
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med (2012) 1.93
Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol (2004) 1.92
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89
Pathways of anaphylaxis in the mouse. J Allergy Clin Immunol (2002) 1.84
Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol (2009) 1.84
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A (2004) 1.79
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest (2006) 1.77
ABO3, a WRKY transcription factor, mediates plant responses to abscisic acid and drought tolerance in Arabidopsis. Plant J (2010) 1.74
Basophils initiate IL-4 production during a memory T-dependent response. J Exp Med (2004) 1.68
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol (2010) 1.67
The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Res (2012) 1.66
A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. Blood (2014) 1.66
Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol (2002) 1.66
Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. Proc Natl Acad Sci U S A (2007) 1.66
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome. Blood (2011) 1.65
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. J Immunol (2002) 1.58
Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal (2008) 1.57
Risk assessment in anaphylaxis: current and future approaches. J Allergy Clin Immunol (2007) 1.57
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation. Clin Cancer Res (2008) 1.55
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Immunol (2008) 1.54
Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine (2010) 1.54
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood (2009) 1.54
FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood (2008) 1.53
Exogenous silicon (Si) increases antioxidant enzyme activity and reduces lipid peroxidation in roots of salt-stressed barley (Hordeum vulgare L.). J Plant Physiol (2003) 1.53
Plant phenomics and high-throughput phenotyping: accelerating rice functional genomics using multidisciplinary technologies. Curr Opin Plant Biol (2013) 1.52
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res (2011) 1.51
Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med (2012) 1.49
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood (2010) 1.48
The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection. J Exp Med (2002) 1.48
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Mol Cancer Ther (2008) 1.48
Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol (2003) 1.47
Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol (2004) 1.46
Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science (2006) 1.44
Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer. Dig Dis Sci (2013) 1.43
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway. J Immunol (2010) 1.41
Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol (2010) 1.40
RTE1 is a Golgi-associated and ETR1-dependent negative regulator of ethylene responses. Plant Physiol (2007) 1.39
Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J Immunol (2004) 1.38
Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med (2011) 1.38
Dynamics of lung macrophage activation in response to helminth infection. J Leukoc Biol (2008) 1.38
Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. J Immunol (2004) 1.38
Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J (2011) 1.38
Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infect Immun (2005) 1.38
Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis. Infect Immun (2012) 1.37
Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer (2009) 1.35
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J Biol Chem (2008) 1.35