Published in Proc Natl Acad Sci U S A on February 11, 2005
Isoelectric focusing technology quantifies protein signaling in 25 cells. Proc Natl Acad Sci U S A (2006) 1.89
Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A (2014) 1.75
TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell (2008) 1.65
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58
Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex. Mol Cell Biol (2007) 1.49
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol (2006) 1.36
Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Mol Cell Biol (2006) 1.24
Updates on HIPK2: a resourceful oncosuppressor for clearing cancer. J Exp Clin Cancer Res (2012) 1.10
Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J (2006) 1.10
Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr (2011) 1.09
Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Cell Cycle (2012) 1.05
The Role of Elongin BC-Containing Ubiquitin Ligases. Front Oncol (2012) 1.04
Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance. Biol Cell (2010) 1.03
Role of transcriptional corepressor CtBP1 in prostate cancer progression. Neoplasia (2012) 1.01
The C-terminal domain of the transcriptional corepressor CtBP is intrinsically unstructured. Protein Sci (2006) 0.92
G protein-coupled receptor kinase 2, with β-arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in ob/ob mouse aorta. Diabetes (2012) 0.89
C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter. Oncogene (2010) 0.89
Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration. J Biol Chem (2013) 0.88
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. J Cell Sci (2010) 0.86
C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. Int J Cell Biol (2013) 0.84
Developmental expression and phylogenetic conservation of alternatively spliced forms of the C-terminal binding protein corepressor. Dev Genes Evol (2006) 0.83
Neuronal PINCH is regulated by TNF-α and is required for neurite extension. J Neuroimmune Pharmacol (2010) 0.82
CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells. Mol Cell Biol (2014) 0.82
Components of the CtBP1/BARS-dependent fission machinery. Histochem Cell Biol (2013) 0.82
Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. Mol Cell Biol (2010) 0.81
CtBP2 downregulation during neural crest specification induces expression of Mitf and REST, resulting in melanocyte differentiation and sympathoadrenal lineage suppression. Mol Cell Biol (2011) 0.81
Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function. Am J Pathol (2011) 0.80
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PLoS One (2012) 0.78
Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity. J Biol Chem (2015) 0.78
HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell (2016) 0.76
PARP1 regulates the protein stability and proapoptotic function of HIPK2. Cell Death Dis (2016) 0.76
HIPK2 modification code for cell death and survival. Mol Cell Oncol (2014) 0.76
Oligomeric form of CtBP coactivates NeuroD1-mediated transcription. FEBS Lett (2016) 0.75
C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis. Mol Cell Neurosci (2013) 0.75
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget (2015) 0.75
The role of cullin 5-containing ubiquitin ligases. Cell Div (2016) 0.75
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev (2000) 6.54
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46
CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell (2002) 4.17
The polycomb protein Pc2 is a SUMO E3. Cell (2003) 3.91
A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol (2001) 3.86
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55
Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol Cell (2002) 3.28
Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A (1995) 3.28
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol (2002) 3.24
Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene (2000) 3.14
Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol (2002) 2.78
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc Natl Acad Sci U S A (2003) 2.03
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem (1998) 1.90
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription. J Biol Chem (1999) 1.71
Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP. Proc Natl Acad Sci U S A (2000) 1.58
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell (2003) 1.57
Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol (2003) 1.50
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol (2004) 1.46
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res (2003) 1.32
Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). J Biol Chem (2002) 1.28
Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol Cell Biol (2000) 1.21
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. Oncogene (2001) 1.15
Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol Cell Biol (2004) 1.15
The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol Cell Biol (2002) 1.13
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene (2004) 1.12
Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons. Curr Biol (2004) 1.05
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A (2008) 3.98
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81
A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron (2002) 2.45
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A (2010) 2.28
An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling. Mol Cell Neurosci (2009) 2.28
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc Natl Acad Sci U S A (2003) 2.03
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. Proc Natl Acad Sci U S A (2007) 1.89
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
Deacetylase activity is required for cAMP activation of a subset of CREB target genes. J Biol Chem (2003) 1.48
A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol (2008) 1.42
A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37
Epigenetic mechanisms and gene networks in the nervous system. J Neurosci (2005) 1.33
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J Biol Chem (2006) 1.21
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2. Proc Natl Acad Sci U S A (2010) 1.14
The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol Cell Biol (2002) 1.08
Role reversal: the regulation of neuronal gene expression by microRNAs. Curr Opin Neurobiol (2005) 1.06
MicroRNA pathways in neural development and plasticity. Curr Opin Neurobiol (2010) 1.04
Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc Natl Acad Sci U S A (2012) 0.96
Regulation of microRNA-375 by cAMP in pancreatic β-cells. Mol Endocrinol (2012) 0.92
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila. Proc Natl Acad Sci U S A (2002) 0.88
Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors. Development (2002) 0.87
MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9. Proc Natl Acad Sci U S A (2013) 0.80
Corrigendum: miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun (2015) 0.76
Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2015) 0.75