Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma.

PubWeight™: 1.60‹?› | Rank: Top 4%

🔗 View Article (PMC 1065335)

Published in Arthritis Res Ther on January 28, 2005

Authors

Hilde Kelchtermans1, Bert De Klerck, Tania Mitera, Maarten Van Balen, Dominique Bullens, Alfons Billiau, Georges Leclercq, Patrick Matthys

Author Affiliations

1: Laboratory of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit Leuven (KULeuven), Leuven, Belgium. hilde.kelchtermans@rega.kuleuven.ac.be

Articles citing this

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity (2009) 3.51

Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest (2006) 2.02

Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Res Ther (2010) 1.95

Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther (2010) 1.90

Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther (2007) 1.63

Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol (2008) 1.58

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36

The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer (2007) 1.27

Progranulin: a promising therapeutic target for rheumatoid arthritis. FEBS Lett (2011) 1.20

Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells. Eur J Immunol (2006) 1.16

Mechanistic insights into immunomodulation by hepatic stellate cells in mice: a critical role of interferon-gamma signaling. Hepatology (2009) 1.16

Parasitic helminths: new weapons against immunological disorders. J Biomed Biotechnol (2010) 1.13

Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res Ther (2009) 1.06

Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest (2013) 1.03

Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo. Immunology (2008) 1.02

IL-12R beta 2 promotes the development of CD4+CD25+ regulatory T cells. J Immunol (2008) 1.01

Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients. J Immunol (2011) 1.01

CD4+CD25+ regulatory T cells in autoimmune arthritis. Immunol Rev (2010) 0.96

IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. J Immunol (2009) 0.93

TRAIL is associated with impaired regulation of CD4+CD25- T cells by regulatory T cells in patients with rheumatoid arthritis. J Clin Immunol (2011) 0.92

The complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev (2014) 0.91

SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice. J Immunol (2011) 0.91

IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Res Ther (2011) 0.91

Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis. J Immunol (2012) 0.90

Regulatory T cells protect from autoimmune arthritis during pregnancy. J Autoimmun (2011) 0.90

C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol (2007) 0.90

Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells. Am J Pathol (2008) 0.90

IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. Am J Transplant (2009) 0.85

Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis. Arthritis Res Ther (2008) 0.85

Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis. Arthritis Res Ther (2014) 0.84

Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis. PLoS One (2012) 0.83

CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment? J Immunol Res (2015) 0.83

Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. Immun Ageing (2009) 0.82

Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis. Front Neurosci (2015) 0.81

Artesunate abolishes germinal center B cells and inhibits autoimmune arthritis. PLoS One (2014) 0.81

Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol (2006) 0.80

Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines. Cytokine (2017) 0.78

Recent progress of elucidating the mechanisms of drug hypersensitivity. Asia Pac Allergy (2012) 0.78

Therapeutic Potential of Interferon-γ and Its Antagonists in Autoinflammation: Lessons from Murine Models of Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome. Pharmaceuticals (Basel) (2015) 0.78

Anti-inflammatory effects of recombinant human PDCD5 (rhPDCD5) in a rat collagen-induced model of arthritis. Inflammation (2015) 0.78

Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement. Rheumatol Int (2013) 0.78

UPDATE ON VACCINE DEVELOPMENT FOR RENAL CELL CANCER. Open Access J Urol (2010) 0.77

Regulatory T-cell vaccination independent of auto-antigen. Exp Mol Med (2014) 0.77

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis. Auto Immun Highlights (2010) 0.77

Exogenous IL-2 controls the balance in Th1, Th17, and Treg cell distribution in patients with progressive rheumatoid arthritis treated with TNF-alpha inhibitors. Inflammation (2015) 0.76

Update on vaccine development for renal cell cancer. Open Access J Urol (2010) 0.76

Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis. PLoS One (2015) 0.76

Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue. Immunology (2012) 0.75

Ellagic acid alleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatory cytokines. Cent Eur J Immunol (2017) 0.75

Indoleamine 2,3-dioxygenase in human hematopoietic stem cell transplantation. Int J Tryptophan Res (2010) 0.75

Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade. Dis Model Mech (2016) 0.75

CTLA-4 expressed by FOXP3(+) Treg cells prevents inflammatory tissue attack and not T cell priming in arthritis. Immunology (2017) 0.75

Articles cited by this

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med (1998) 19.03

Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol (1999) 8.98

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med (2001) 8.69

CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol (1998) 7.31

Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98

An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods (2001) 6.68

Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol (2002) 4.95

Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene (2002) 4.15

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol (2004) 3.79

The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med (1987) 3.66

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol (2000) 3.63

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol (1997) 3.35

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med (1985) 2.92

CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum (2003) 2.68

Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J Leukoc Biol (2001) 2.61

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J Immunol (1997) 2.59

Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2002) 2.35

TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev (2003) 2.20

CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol (2003) 2.19

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A (2003) 2.14

Interferon-gamma: biology and role in pathogenesis. Adv Immunol (1996) 2.08

Biology of the interleukin-2 receptor. Adv Immunol (1998) 2.08

Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum (2001) 1.92

Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum (1986) 1.90

Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol (2003) 1.89

CD4(+) regulatory T cells. Curr Opin Immunol (2001) 1.78

Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med (2003) 1.59

Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. Eur J Immunol (1996) 1.43

Female sex hormones suppress development of collagen-induced arthritis in mice. Arthritis Rheum (1986) 1.37

Enhanced autoimmune arthritis in IFN-gamma receptor-deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells. J Immunol (1999) 1.30

IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. Ann Rheum Dis (2003) 1.19

RANTES and MIP-1alpha activate stats in T cells. J Biol Chem (1998) 1.13

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis. Arthritis Res Ther (2004) 1.10

CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther (2003) 1.04

Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen. Arthritis Res Ther (2004) 1.02

Mac-1(+) myelopoiesis induced by CFA: a clue to the paradoxical effects of IFN-gamma in autoimmune disease models. Trends Immunol (2001) 0.98

Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production. J Exp Med (2004) 0.96

Influence of CD4 or CD8 deficiency on collagen-induced arthritis. Immunology (2001) 0.91

A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses. Arthritis Res Ther (2003) 0.85

Articles by these authors

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med (2002) 5.50

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education. Immunity (2009) 2.62

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21

Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR-10) protein allergy resolved after immunotherapy. J Allergy Clin Immunol (2013) 2.06

Interferon-gamma: a historical perspective. Cytokine Growth Factor Rev (2009) 2.03

Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Res Ther (2010) 1.95

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet (2011) 1.78

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum (2009) 1.70

Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages. Blood (2004) 1.58

How interferon-gamma keeps autoimmune diseases in check. Trends Immunol (2008) 1.53

Generation of T cells from human embryonic stem cell-derived hematopoietic zones. J Immunol (2009) 1.51

Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol (2007) 1.47

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. Blood (2008) 1.45

CD27 defines phenotypically and functionally different human NK cell subsets. J Immunol (2008) 1.44

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. Blood (2008) 1.44

KLRG1 binds cadherins and preferentially associates with SHIP-1. Int Immunol (2007) 1.41

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36

Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med (2009) 1.25

Interactions of Ly49 family receptors with MHC class I ligands in trans and cis. J Immunol (2007) 1.24

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development. Blood (2008) 1.23

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines. Eur J Immunol (2008) 1.20

Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis (2010) 1.10

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis. Arthritis Res Ther (2004) 1.10

Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production. J Leukoc Biol (2007) 1.09

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes (2005) 1.09

Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice. J Immunol (2002) 1.08

Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis Rheum (2006) 1.07

Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res Ther (2009) 1.06

Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood (2005) 1.04

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases. J Neurosci (2012) 1.04

Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. J Immunol (2004) 1.03

IL-12 contributes to allergen-induced airway inflammation in experimental asthma. J Immunol (2006) 1.01

Collagen-induced arthritis as an animal model for rheumatoid arthritis: focus on interferon-γ. J Interferon Cytokine Res (2011) 1.01

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. J Exp Med (2013) 1.00

Active form of Notch imposes T cell fate in human progenitor cells. J Immunol (2002) 0.99

Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis. Arthritis Res Ther (2005) 0.99

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions. Blood (2011) 0.99

Education of murine NK cells requires both cis and trans recognition of MHC class I molecules. J Immunol (2013) 0.99

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. J Immunol (2009) 0.98

A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J Immunol (2007) 0.97

SPECT imaging of joint inflammation with Nanobodies targeting the macrophage mannose receptor in a mouse model for rheumatoid arthritis. J Nucl Med (2013) 0.97

Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals. PLoS One (2013) 0.97

Pepsin and bile acids in induced sputum of chronic cough patients. Respir Med (2011) 0.97

T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response. Haematologica (2009) 0.96

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells. Blood (2007) 0.96

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation. Immunol Cell Biol (2011) 0.95

Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges. J Pharm Pharmacol (2004) 0.95

A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells. Proc Natl Acad Sci U S A (2006) 0.95

Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes. J Immunol (2002) 0.93

Freund's complete adjuvant induces arthritis in mice lacking a functional interferon-gamma receptor by triggering tumor necrosis factor alpha-driven osteoclastogenesis. Arthritis Rheum (2007) 0.93

NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2. Eur J Immunol (2002) 0.93

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells. Haematologica (2011) 0.93

Dependence on interferon-gamma for the spontaneous occurrence of arthritis in DBA/1 mice. Arthritis Rheum (2003) 0.92

Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory? Cytokine Growth Factor Rev (2011) 0.92

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood (2002) 0.91

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma. J Immunol (2003) 0.91

Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques. Arthritis Res Ther (2014) 0.91

β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J Control Release (2013) 0.90

Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ. J Autoimmun (2011) 0.89

Negative thymocyte selection to HERV-K18 superantigens in humans. Blood (2005) 0.88

Haptoglobin deficiency facilitates the development of autoimmune inflammation. Eur J Immunol (2009) 0.88

Macrophages have no lineage history of Foxp3 expression. Blood (2012) 0.87

A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines. J Allergy Clin Immunol (2009) 0.87

Role of natural killer cells in the rejection process of corneal allografts in rats. Transplantation (2004) 0.87

New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population. J Neuroimmunol (2003) 0.86

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. Blood (2011) 0.86

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia. Haematologica (2012) 0.86

Continuous CD27 triggering in vivo strongly reduces NK cell numbers. Eur J Immunol (2010) 0.86

Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ. Arthritis Rheumatol (2014) 0.85

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells. Blood (2005) 0.85

Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection. J Leukoc Biol (2010) 0.84

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function. J Leukoc Biol (2013) 0.84

Foxp3+CD25+ T regulatory cells stimulate IFN-gamma-independent CD152-mediated activation of tryptophan catabolism that provides dendritic cells with immune regulatory activity in mice unresponsive to staphylococcal enterotoxin B. J Immunol (2007) 0.84

Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice. BMC Microbiol (2003) 0.84

TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells. Curr Pharm Des (2012) 0.83

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells. J Immunol (2013) 0.83

Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis. Int Immunopharmacol (2004) 0.82