Published in J Leukoc Biol on March 17, 2005
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron (2007) 2.13
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol (2010) 1.82
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med (2007) 1.81
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells. J Exp Med (2007) 1.77
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest (2007) 1.77
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med (2014) 1.68
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood (2008) 1.65
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood (2009) 1.54
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood (2008) 1.35
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A (2007) 1.31
Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2. Blood (2006) 1.28
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology (2007) 1.21
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis (2011) 1.18
Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models. Mol Ther (2009) 1.15
The multiple faces of leukocyte interstitial migration. Semin Immunopathol (2014) 1.12
Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol (2009) 1.06
Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest. Front Immunol (2012) 1.00
Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells. J Exp Med (2013) 1.00
Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state. Blood (2010) 1.00
The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol (2010) 0.96
Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood (2012) 0.96
Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro. J Inflamm (Lond) (2010) 0.95
Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One (2010) 0.94
The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal (2011) 0.91
Development of lentiviral gene therapy for Wiskott Aldrich syndrome. Expert Opin Biol Ther (2008) 0.91
Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol (2011) 0.91
Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome. Mol Ther (2012) 0.91
Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90
CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes. J Biol Chem (2010) 0.88
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med (2010) 0.87
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology (2012) 0.87
Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J Biol Chem (2011) 0.87
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J Allergy Clin Immunol (2012) 0.82
Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep (2013) 0.81
Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Immunology (2012) 0.80
Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. J Biol Chem (2013) 0.79
The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells. J Immunol (2011) 0.78
Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome. Front Immunol (2015) 0.77
T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors. Front Immunol (2015) 0.77
Congenital defects in neutrophil dynamics. J Immunol Res (2014) 0.76
Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability. FASEB J (2016) 0.76
Human Immunodeficiencies Related to Defective APC/T Cell Interaction. Front Immunol (2015) 0.75
Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein. PLoS One (2014) 0.75
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α. Sci Rep (2015) 0.75
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol (2003) 15.51
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol (2005) 7.47
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol (2006) 6.23
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol (2008) 5.37
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science (2006) 5.31
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell (2007) 5.17
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol (2004) 5.07
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature (2007) 4.88
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol (2008) 4.52
Dynamic visualization of thrombopoiesis within bone marrow. Science (2007) 4.35
Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol (2010) 4.34
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature (2010) 3.71
HIV-infected T cells are migratory vehicles for viral dissemination. Nature (2012) 3.57
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity (2005) 3.39
Intravital microscopy: visualizing immunity in context. Immunity (2004) 3.37
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology (2012) 3.28
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol (2009) 3.13
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Stem-cell gene therapy for the Wiskott-Aldrich syndrome. N Engl J Med (2010) 3.09
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol (2005) 3.07
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity (2007) 3.07
Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation (2003) 3.04
Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med (2005) 3.02
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity (2009) 2.98
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol (2006) 2.94
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med (2006) 2.85
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med (2007) 2.81
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol (2006) 2.73
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med (2006) 2.69
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49
Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (2006) 2.49
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J Exp Med (2006) 2.43
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment. Nat Immunol (2007) 2.41
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007) 2.41
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38
Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med (2003) 2.36
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A (2002) 2.32
A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med (2009) 2.30
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
The clearance mechanism of chilled blood platelets. Cell (2003) 2.25
Unraveling V(D)J recombination; insights into gene regulation. Cell (2004) 2.25
Mechanisms and consequences of dendritic cell migration. Immunity (2008) 2.25
Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping. Circ Cardiovasc Imaging (2011) 2.21
Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery. Circulation (2004) 2.20
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19
Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A (2006) 2.17
H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle (2004) 2.16
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
In vivo imaging of lymphocyte trafficking. Annu Rev Cell Dev Biol (2005) 2.15