Published in Int J Parasitol on April 01, 2005
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res (2011) 1.90
Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum. Nucleic Acids Res (2009) 1.27
Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. Int J Parasitol (2009) 1.12
Comparative genomics: from genotype to disease phenotype in the leishmaniases. Int J Parasitol (2007) 1.09
Characterization of the RNA polymerase II and III complexes in Leishmania major. Int J Parasitol (2006) 0.94
Genetic, serological and biochemical characterization of Leishmania tropica from foci in northern Palestine and discovery of zymodeme MON-307. Parasit Vectors (2012) 0.88
Drug resistance analysis by next generation sequencing in Leishmania. Int J Parasitol Drugs Drug Resist (2014) 0.87
Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons. BMC Genomics (2007) 0.86
Comparative genomics of Tunisian Leishmania major isolates causing human cutaneous leishmaniasis with contrasting clinical severity. Infect Genet Evol (2016) 0.75
Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management. PLoS Negl Trop Dis (2016) 0.75
Evidence for viable and stable triploid Trypanosoma congolense parasites. Parasit Vectors (2017) 0.75
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog (2010) 3.65
Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol Cell (2003) 2.54
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Mol Biochem Parasitol (2006) 2.45
Identification of novel components of Trypanosoma brucei editosomes. RNA (2003) 2.30
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates. BMC Genomics (2007) 2.23
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics (2009) 2.00
An essential RNase III insertion editing endonuclease in Trypanosoma brucei. Proc Natl Acad Sci U S A (2005) 1.96
Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell (2003) 1.94
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics (2009) 1.94
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome. Mol Cell (2003) 1.88
RNA editing in Trypanosoma brucei requires three different editosomes. Mol Cell Biol (2007) 1.87
GeneDB--an annotation database for pathogens. Nucleic Acids Res (2011) 1.82
Mitochondrial complexes in Trypanosoma brucei: a novel complex and a unique oxidoreductase complex. Mol Cell Proteomics (2007) 1.81
Transcription initiation and termination on Leishmania major chromosome 3. Eukaryot Cell (2004) 1.67
TbMP81 is required for RNA editing in Trypanosoma brucei. EMBO J (2002) 1.65
RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei. J Biol Chem (2004) 1.58
A deletion site editing endonuclease in Trypanosoma brucei. Mol Cell (2005) 1.57
Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell (2002) 1.55
Comparative analysis of editosome proteins in trypanosomatids. Nucleic Acids Res (2003) 1.52
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46
Histone acetylations mark origins of polycistronic transcription in Leishmania major. BMC Genomics (2009) 1.46
Shotgun optical mapping of the entire Leishmania major Friedlin genome. Mol Biochem Parasitol (2004) 1.45
Trypanosoma brucei mitochondrial ribosomes: affinity purification and component identification by mass spectrometry. Mol Cell Proteomics (2008) 1.44
TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell (2003) 1.39
Gene synteny and evolution of genome architecture in trypanosomatids. Mol Biochem Parasitol (2004) 1.36
Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei. J Am Soc Mass Spectrom (2003) 1.35
A novel active DNA topoisomerase I in Leishmania donovani. J Biol Chem (2002) 1.35
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene. Nucleic Acids Res (2003) 1.29
Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.27
SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics (2011) 1.23
Combining functional and structural genomics to sample the essential Burkholderia structome. PLoS One (2013) 1.21
Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol (2008) 1.20
KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2006) 1.19
Post-translational modification of cellular proteins during Leishmania donovani differentiation. Proteomics (2008) 1.19
RNA sequence and base pairing effects on insertion editing in Trypanosoma brucei. Mol Cell Biol (2002) 1.15
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis, and cell cycle. J Biol Chem (2005) 1.13
Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. Int J Parasitol (2008) 1.13
The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol (2009) 1.11
Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis. Mol Biochem Parasitol (2003) 1.11
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei. RNA (2007) 1.08
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. J Exp Med (2013) 1.08
Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei. BMC Genomics (2014) 1.07
Endonuclease associations with three distinct editosomes in Trypanosoma brucei. J Biol Chem (2011) 1.07
Differential functions of two editosome exoUases in Trypanosoma brucei. RNA (2009) 1.06
Kinetoplastid RNA editing ligases: complex association, characterization, and substrate requirements. Mol Biochem Parasitol (2003) 1.05
Identification of essential and non-essential protein kinases by a fusion PCR method for efficient production of transgenic Trypanosoma brucei. Mol Biochem Parasitol (2013) 1.02
Biomediator data integration and inference for functional annotation of anonymous sequences. Pac Symp Biocomput (2007) 1.02
Endoribonuclease activities of Trypanosoma brucei mitochondria. Mol Biochem Parasitol (2002) 1.00
Genomic organization and gene expression in a chromosomal region of Leishmania major. Mol Biochem Parasitol (2004) 1.00
Solution structure of Rv2377c-founding member of the MbtH-like protein family. Tuberculosis (Edinb) (2010) 1.00
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem (2006) 1.00
Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head. PLoS One (2010) 0.98
Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications. Mol Biochem Parasitol (2006) 0.95
Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major. Mol Biochem Parasitol (2002) 0.94
Characterization of the RNA polymerase II and III complexes in Leishmania major. Int J Parasitol (2006) 0.94
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.93
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics (2011) 0.92
A low-background inducible promoter system in Leishmania donovani. Mol Biochem Parasitol (2002) 0.91
Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function. RNA (2012) 0.90
A survey of Leishmania braziliensis genome by shotgun sequencing. Mol Biochem Parasitol (2004) 0.90
A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity. J Biomol Screen (2012) 0.89
Gene organization and sequence analyses of transfer RNA genes in Trypanosomatid parasites. BMC Genomics (2009) 0.89
Sense and antisense transcripts in the histone H1 (HIS-1) locus of Leishmania major. Int J Parasitol (2003) 0.89
Selecting targets from eukaryotic parasites for structural genomics and drug discovery. Methods Mol Biol (2014) 0.87
KREPB6, KREPB7, and KREPB8 are important for editing endonuclease function in Trypanosoma brucei. RNA (2011) 0.87
Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex. Eukaryot Cell (2008) 0.87
Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei. J Mol Biol (2008) 0.87
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob Agents Chemother (2013) 0.86
Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation. J Biol Chem (2011) 0.86
Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei. Eukaryot Cell (2012) 0.85
Kinetoplastid-specific histone variant functions are conserved in Leishmania major. Mol Biochem Parasitol (2013) 0.85
Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.85
A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes. Mol Cell Biol (2013) 0.85
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci (2005) 0.85
Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug. Biochem Biophys Res Commun (2005) 0.85
Trypanosomatid flagellum biogenesis: ARL-3A is involved in several species. Exp Parasitol (2004) 0.84
Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins. Protein Sci (2012) 0.84
KREX2 is not essential for either procyclic or bloodstream form Trypanosoma brucei. PLoS One (2012) 0.84
Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.83
Synthesis of antitrypanosomal 1,2-dioxane derivatives based on a natural product scaffold. Bioorg Med Chem Lett (2011) 0.83
An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.83
Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry (2011) 0.83
Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei. Eukaryot Cell (2014) 0.82
Fragment screening of infectious disease targets in a structural genomics environment. Methods Enzymol (2011) 0.82
A hammerhead ribozyme substrate and reporter for in vitro kinetoplastid RNA editing. RNA (2002) 0.82
Importing statistical measures into Artemis enhances gene identification in the Leishmania genome project. BMC Bioinformatics (2003) 0.81
Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipeline. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.81
Inaugural structure from the DUF3349 superfamily of proteins, Mycobacterium tuberculosis Rv0543c. Arch Biochem Biophys (2010) 0.81
New Trypanosoma cruzi repeated element that shows site specificity for insertion. Eukaryot Cell (2007) 0.81
Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.81