Published in Nature on March 31, 2005
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Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature (2010) 3.77
Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res (2006) 3.43
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
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Bacterial argonaute samples the transcriptome to identify foreign DNA. Mol Cell (2013) 2.47
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
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Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell (2012) 1.81
Highly complementary target RNAs promote release of guide RNAs from human Argonaute2. Mol Cell (2013) 1.81
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res (2010) 1.64
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Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements. Biol Direct (2009) 1.58
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Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA (2009) 1.55
The N domain of Argonaute drives duplex unwinding during RISC assembly. Nat Struct Mol Biol (2012) 1.55
Specific residues at every third position of siRNA shape its efficient RNAi activity. Nucleic Acids Res (2007) 1.49
Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol Genet Genomics (2010) 1.48
Genome-wide identification, organization and phylogenetic analysis of Dicer-like, Argonaute and RNA-dependent RNA Polymerase gene families and their expression analysis during reproductive development and stress in rice. BMC Genomics (2008) 1.46
Binding and cleavage specificities of human Argonaute2. J Biol Chem (2009) 1.45
Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination. PLoS Pathog (2012) 1.44
Structural biology of RNA silencing and its functional implications. Cold Spring Harb Symp Quant Biol (2006) 1.42
The evolutionary journey of Argonaute proteins. Nat Struct Mol Biol (2014) 1.41
Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol (2010) 1.40
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res (2008) 1.37
Therapeutic siRNA: principles, challenges, and strategies. Yale J Biol Med (2012) 1.35
Structural insights into RNA interference. Curr Opin Struct Biol (2010) 1.34
Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33
siRNA repositioning for guide strand selection by human Dicer complexes. Mol Cell (2011) 1.31
A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like Argonaute in the single-cell human parasite Toxoplasma gondii. PLoS Pathog (2010) 1.27
MiRmap: comprehensive prediction of microRNA target repression strength. Nucleic Acids Res (2012) 1.27
A systematic analysis of the effect of target RNA structure on RNA interference. Nucleic Acids Res (2007) 1.27
Ancestral roles of small RNAs: an Ago-centric perspective. Cold Spring Harb Perspect Biol (2011) 1.27
How to slice: snapshots of Argonaute in action. Silence (2010) 1.26
Discovering the first microRNA-targeted drug. J Cell Biol (2012) 1.26
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A (2013) 1.26
RNA silencing in Chlamydomonas: mechanisms and tools. Curr Genet (2005) 1.24
MicroRNA Processing and Human Cancer. J Clin Med (2015) 1.23
Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. EMBO J (2012) 1.21
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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs. Angew Chem Int Ed Engl (2011) 1.20
Argonautes confront new small RNAs. Curr Opin Chem Biol (2007) 1.20
MicroRNA metabolism in plants. Curr Top Microbiol Immunol (2008) 1.20
Evidence for co-evolution between human microRNAs and Alu-repeats. PLoS One (2009) 1.19
Structural and functional modules in RNA interference. Curr Opin Struct Biol (2009) 1.19
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (2010) 1.19
Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A (2006) 1.15
The making of a slicer: activation of human Argonaute-1. Cell Rep (2013) 1.15
The evolution of core proteins involved in microRNA biogenesis. BMC Evol Biol (2008) 1.14
A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA. Structure (2006) 1.12
Dicer is dispensable for asymmetric RISC loading in mammals. RNA (2011) 1.11
Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch. Biol Direct (2008) 1.11
Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Ther (2012) 1.10
Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier. Mol Ther Nucleic Acids (2013) 1.10
DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells. Dev Genes Evol (2006) 1.10
The PIWI protein acts as a predictive marker for human gastric cancer. Int J Clin Exp Pathol (2012) 1.09
A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence (2011) 1.08
Eukaryote-specific insertion elements control human ARGONAUTE slicer activity. Cell Rep (2013) 1.08
The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2. Biochem J (2009) 1.07
RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Res (2008) 1.07
Multilayer checkpoints for microRNA authenticity during RISC assembly. EMBO Rep (2011) 1.06
Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. Proc Natl Acad Sci U S A (2009) 1.05
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif. Biol Direct (2009) 1.02
Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus. BMC Genomics (2013) 1.01
Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs. Nucleic Acids Res (2011) 1.00
High potency silencing by single-stranded boranophosphate siRNA. Nucleic Acids Res (2006) 1.00
RNAi in Plants: An Argonaute-Centered View. Plant Cell (2016) 0.98
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
Prediction of mammalian microRNA targets. Cell (2003) 53.70
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15
Mechanisms of gene silencing by double-stranded RNA. Nature (2004) 16.82
Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell (2001) 10.20
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
A protein sensor for siRNA asymmetry. Science (2004) 7.77
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature (2004) 7.63
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol (2004) 7.26
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Revealing the world of RNA interference. Nature (2004) 5.92
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38
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Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature (2006) 5.42
GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 4.60
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell (2005) 4.24
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell (2005) 4.05
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell (2002) 3.53
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell (2003) 2.83
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem (2005) 2.68
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol Cell (2009) 2.32
Argonaute: A scaffold for the function of short regulatory RNAs. Trends Biochem Sci (2006) 2.28
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol Cell (2008) 2.27
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J (2003) 2.25
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J (2003) 2.14
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature (2011) 2.07
Structure of the A20 OTU domain and mechanistic insights into deubiquitination. Biochem J (2008) 1.94
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell (2006) 1.91
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J (2004) 1.86
Getting into position: the catalytic mechanisms of protein ubiquitylation. Biochem J (2004) 1.83
Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. Mol Cell (2004) 1.81
Structural basis for the subunit assembly of the anaphase-promoting complex. Nature (2011) 1.80
The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings. Structure (2012) 1.78
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem (2004) 1.72
Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol Cell (2005) 1.65
Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal (2005) 1.62
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J (2007) 1.55
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49
Molecular recognition via coupled folding and binding in a TPR domain. J Mol Biol (2005) 1.48
Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell (2006) 1.48
Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. J Mol Biol (2003) 1.47
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An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell (2008) 1.36
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell (2011) 1.34
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Lining the pockets of kinases and phosphatases. Curr Opin Struct Biol (2006) 1.30
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. EMBO J (2011) 1.30
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J (2004) 1.29
Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Res (2006) 1.28
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev (2008) 1.27
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry (2007) 1.26
Differential oxidation of protein-tyrosine phosphatases. J Biol Chem (2004) 1.24
Structure of TOR and its complex with KOG1. Mol Cell (2007) 1.23
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep (2005) 1.21
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell (2013) 1.21
A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. J Mol Biol (2007) 1.20
Regulation of protein kinases in insulin, growth factor and Wnt signalling. Curr Opin Struct Biol (2002) 1.20
The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. EMBO J (2010) 1.19
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. Structure (2006) 1.18
Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin. J Mol Biol (2002) 1.18
Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg Med Chem Lett (2005) 1.17
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem (2007) 1.13
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. J Mol Biol (2002) 1.13
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Res (2004) 1.12
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. Structure (2002) 1.12
Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chem Biol (2009) 1.10
Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). Biochem J (2013) 1.09
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res (2007) 1.07
Identification of inhibitors of protein kinase B using fragment-based lead discovery. J Med Chem (2007) 1.06
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. Mol Cell (2009) 1.05
Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. J Mol Biol (2010) 1.04
Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. Mol Cell (2006) 1.04
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem (2008) 1.04
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. J Biol Chem (2011) 1.03
Purification and assay of the budding yeast anaphase-promoting complex. Methods Enzymol (2005) 1.02
Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases. Trends Biochem Sci (2009) 1.01
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT. Mol Cell (2011) 1.00
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry (2007) 0.99
Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS One (2012) 0.96
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (2005) 0.96
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol (2006) 0.96
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem (2013) 0.94
Pellino1 is required for interferon production by viral double-stranded RNA. J Biol Chem (2012) 0.89
Getting in the ring: proline-directed substrate specificity in the cell cycle proteins Cdc14 and CDK2-cyclinA3. Cell Cycle (2003) 0.88
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. J Mol Biol (2013) 0.86
Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem (2008) 0.86
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. FASEB J (2011) 0.85
Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. Nucleic Acids Res (2003) 0.85
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. Pharmacol Ther (2002) 0.83
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PLoS One (2012) 0.80