Published in Cell on April 08, 2005
Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science (2010) 3.72
Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol (2007) 2.24
Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03
Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science (2008) 2.01
p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron (2008) 1.97
Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. Mol Biol Cell (2006) 1.69
Visual map development: bidirectional signaling, bifunctional guidance molecules, and competition. Cold Spring Harb Perspect Biol (2010) 1.65
Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev (2010) 1.64
Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation. PLoS Biol (2014) 1.53
Target-independent ephrina/EphA-mediated axon-axon repulsion as a novel element in retinocollicular mapping. Neuron (2014) 1.51
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. Am J Pathol (2009) 1.46
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell (2010) 1.42
Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene (2008) 1.41
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem (2009) 1.39
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Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
Motor axon pathfinding. Cold Spring Harb Perspect Biol (2010) 1.31
Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection. J Neurosci (2009) 1.29
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Eph/ephrin signaling in epithelial development and homeostasis. Int J Biochem Cell Biol (2008) 1.14
Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell (2012) 1.12
Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. J Cell Sci (2010) 1.11
Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res (2008) 1.10
Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron (2012) 1.08
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Drosophila Eph receptor guides specific axon branches of mushroom body neurons. Development (2006) 1.07
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Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development (2009) 1.05
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Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain. Eur J Neurosci (2012) 1.04
Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1. J Neurosci (2008) 1.04
Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol (2006) 0.99
EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Differ (2012) 0.99
Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. J Neurosci (2010) 0.99
The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol (2014) 0.97
Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice. PLoS One (2012) 0.96
Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci U S A (2013) 0.95
PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci (2014) 0.95
Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues. J Neurosci (2012) 0.95
Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS One (2013) 0.94
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat Commun (2013) 0.93
Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochim Biophys Acta (2013) 0.93
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron (2014) 0.92
The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system. Philos Trans R Soc Lond B Biol Sci (2006) 0.92
Linking cell fate, trajectory choice, and target selection: genetic analysis of Sema-2b in olfactory axon targeting. Neuron (2013) 0.90
EphrinA6 on chick retinal axons is a key component for p75(NTR)-dependent axon repulsion and TrkB-dependent axon branching. Mol Cell Neurosci (2011) 0.89
Brain-Region Specific Apoptosis Triggered by Eph/ephrin Signaling. Exp Neurobiol (2013) 0.88
Fast rearrangement of the neuronal growth cone's actin cytoskeleton following VEGF stimulation. Histochem Cell Biol (2012) 0.85
EphB3 receptor and ligand expression in the adult rat brain. J Mol Histol (2006) 0.85
cAMP-induced expression of neuropilin1 promotes retinal axon crossing in the zebrafish optic chiasm. J Neurosci (2013) 0.85
Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife (2015) 0.85
Eph receptor tyrosine kinases in cancer stem cells. Cytokine Growth Factor Rev (2014) 0.84
Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol (2015) 0.83
Direct live monitoring of heterotypic axon-axon interactions in vitro. Nat Protoc (2012) 0.83
EphA4 is necessary for spatially selective peripheral somatosensory topography. Dev Dyn (2010) 0.83
Semaphorins deployed to repel cell migrants at spinal cord borders. J Biol (2008) 0.83
Eph/ephrin signaling in epidermal differentiation and disease. Semin Cell Dev Biol (2011) 0.82
Transgenic overexpression of ephrin b1 in bone cells promotes bone formation and an anabolic response to mechanical loading in mice. PLoS One (2013) 0.82
Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. Proc Natl Acad Sci U S A (2011) 0.82
Regulation of signaling interactions and receptor endocytosis in growing blood vessels. Cell Adh Migr (2014) 0.82
Axon guidance in the auditory system: multiple functions of Eph receptors. Neuroscience (2014) 0.81
In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities. Mol Cells (2014) 0.81
Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci (2014) 0.81
Expression profile and role of EphrinA1 ligand after spinal cord injury. Cell Mol Neurobiol (2011) 0.81
TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex. J Neurosci (2012) 0.80
Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome. BMC Evol Biol (2005) 0.80
Ectopic Expression of Ephrin-A5 Under the EphA8 Promoter at the Anterior Region of the Superior Colliculus. Exp Neurobiol (2010) 0.80
Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system. Neural Dev (2012) 0.80
Spatial organization acts on cell signaling: how physical force contributes to the development of cancer. Breast Cancer Res (2010) 0.80
Eph-ephrin signaling in nervous system development. F1000Res (2016) 0.79
Reverse signaling by glycosylphosphatidylinositol-linked Manduca ephrin requires a SRC family kinase to restrict neuronal migration in vivo. J Neurosci (2009) 0.79
Regulation of cell differentiation by Eph receptor and ephrin signaling. Cell Adh Migr (2014) 0.79
The role of proteases in regulating Eph/ephrin signaling. Cell Adh Migr (2014) 0.78
Eph-ephrin bidirectional signaling comes into the context of lymphocyte transendothelial migration. Cell Adh Migr (2010) 0.78
Homotypic receptor-receptor interactions regulating Eph signaling. Cell Adh Migr (2014) 0.78
Complementary expression of EphA7 and SCO-spondin during posterior commissure development. Front Neuroanat (2014) 0.77
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EphA7 regulates spiral ganglion innervation of cochlear hair cells. Dev Neurobiol (2015) 0.76
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest (2017) 0.76
EphA4 Regulates Neuroblast and Astrocyte Organization in a Neurogenic Niche. J Neurosci (2017) 0.75
Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe. PLoS One (2012) 0.75
Axon guidance: opposing EPHects in the growth cone. Cell (2005) 0.75
The Neural Cell Adhesion Molecule NCAM Promotes Clustering and Activation of EphA3 Receptors in GABAergic Interneurons to Induce RhoA/ROCK-mediated Growth Cone Collapse. J Biol Chem (2016) 0.75
Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells. Stem Cells Int (2016) 0.75
Grading the thalamus: how can an 'Eph' be excellent? Thalamus Relat Syst (2005) 0.75
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell (2003) 8.00
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59
TAM receptors are pleiotropic inhibitors of the innate immune response. Cell (2007) 5.32
Human host factors required for influenza virus replication. Nature (2010) 5.28
Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A (2004) 4.13
Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature (2012) 3.96
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell (2003) 3.87
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci (2002) 3.48
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Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol (2002) 3.32
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron (2003) 3.08
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96
Kinomics: methods for deciphering the kinome. Nat Methods (2005) 2.94
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell (2002) 2.94
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
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Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays. Hum Mol Genet (2005) 2.56
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Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell (2005) 2.48
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28
Small CTD phosphatases function in silencing neuronal gene expression. Science (2005) 2.23
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron (2007) 2.19
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Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science (2008) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
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Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86
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Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A (2005) 1.85
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The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer (2010) 1.80
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol (2002) 1.72
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72
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A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
Inhibition of retroviral pathogenesis by RNA interference. Curr Biol (2002) 1.70
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A (2013) 1.64
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Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell (2006) 1.62
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
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Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell (2004) 1.47
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol (2003) 1.47
Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab (2006) 1.44
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A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
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Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol (2007) 1.36
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
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Motor axon pathfinding. Cold Spring Harb Perspect Biol (2010) 1.31
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A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Rep (2003) 1.24
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