Published in Mol Cell on April 15, 2005
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Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol (2006) 1.89
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The DNA repair genes XPB and XPD defend cells from retroviral infection. Proc Natl Acad Sci U S A (2006) 1.18
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Structure of a thiol monolayer-protected gold nanoparticle at 1.1 A resolution. Science (2007) 4.73
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A (2004) 4.13
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A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A (2001) 3.87
The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol (2008) 3.86
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab (2006) 3.71
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol (2005) 3.46
Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms. Science (2004) 3.46
Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center. Cell (2004) 3.34
MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem (2009) 3.34
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol (2002) 3.32
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
A selective filter for cytoplasmic transport at the axon initial segment. Cell (2009) 3.09
Structural basis of transcription: separation of RNA from DNA by RNA polymerase II. Science (2004) 3.08
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96
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Kinomics: methods for deciphering the kinome. Nat Methods (2005) 2.94
Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription. Proc Natl Acad Sci U S A (2003) 2.92
Removal of promoter nucleosomes by disassembly rather than sliding in vivo. Mol Cell (2004) 2.90
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell (2005) 2.88
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell (2003) 2.69
Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science (2009) 2.68
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell (2002) 2.64
The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell (2008) 2.62
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59
Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol (2011) 2.54
The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A (2004) 2.50
Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell (2005) 2.48
Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature (2010) 2.47
Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription. Cell (2008) 2.47
Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism. Science (2009) 2.43
Chromatin remodeling by nucleosome disassembly in vitro. Proc Natl Acad Sci U S A (2006) 2.41
Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol (2008) 2.38
Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A (2002) 2.37
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell (2002) 2.32
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood (2012) 2.22
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A (2007) 2.17
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron (2011) 2.02
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Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr Biol (2011) 1.99
A Doppler transient model based on the laplace wavelet and spectrum correlation assessment for locomotive bearing fault diagnosis. Sensors (Basel) (2013) 1.97
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Mediator as a general transcription factor. J Biol Chem (2005) 1.88
Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation (2007) 1.88
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A (2005) 1.85
A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem (2002) 1.84
Integrated catalytic conversion of gamma-valerolactone to liquid alkenes for transportation fuels. Science (2010) 1.83
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol (2006) 1.82
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates. Proc Natl Acad Sci U S A (2003) 1.82
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer (2010) 1.80
Homologous recombination as an evolutionary force in the avian influenza A virus. Mol Biol Evol (2008) 1.79
Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Mol Endocrinol (2010) 1.77
A synthetic precedent for the [FeIV2(mu-O)2] diamond core proposed for methane monooxygenase intermediate Q. Proc Natl Acad Sci U S A (2007) 1.76
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle (2010) 1.74
Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol (2009) 1.74
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A (2009) 1.74
Head module control of mediator interactions. Mol Cell (2006) 1.72
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol (2002) 1.72
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72
A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. Plant Cell (2006) 1.71
A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer's disease. Clin Interv Aging (2013) 1.69
Edge-based scoring and searching method for identifying condition-responsive protein-protein interaction sub-network. Bioinformatics (2007) 1.69
5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol (2012) 1.67
Click chemistry, a powerful tool for pharmaceutical sciences. Pharm Res (2008) 1.67
Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood (2013) 1.66
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell (2009) 1.64
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell (2006) 1.62
Protein identification using customized protein sequence databases derived from RNA-Seq data. J Proteome Res (2011) 1.62
Structure of a RSC-nucleosome complex and insights into chromatin remodeling. Nat Struct Mol Biol (2008) 1.62
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
RNA polymerase II/TFIIF structure and conserved organization of the initiation complex. Mol Cell (2003) 1.60
Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy. Hypertension (2012) 1.60