Published in Diabetes on May 01, 2005
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes (2009) 8.81
Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest (2013) 3.38
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol (2006) 2.06
Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology (2013) 1.49
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation. EJNMMI Res (2011) 1.31
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell (2011) 1.21
Brown adipose tissue as a regulator of energy expenditure and body fat in humans. Diabetes Metab J (2013) 1.13
Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse. J Physiol (2007) 1.11
Changes in brown adipose tissue in boys and girls during childhood and puberty. J Pediatr (2011) 1.04
Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes (2014) 1.03
Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes (2013) 1.02
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Am J Physiol Endocrinol Metab (2013) 0.94
Temperature changes in brown adipocytes detected with a bimaterial microcantilever. Biophys J (2014) 0.93
Targeting presynaptic norepinephrine transporter in brown adipose tissue: a novel imaging approach and potential treatment for diabetes and obesity. Synapse (2012) 0.93
Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav (2009) 0.87
Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress. J Nucl Med (2011) 0.87
Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation. J Cell Biol (2014) 0.87
Brown adipose tissue in the treatment of obesity and diabetes: Are we hot enough? J Diabetes Investig (2011) 0.87
Adrenergic pathway activation enhances brown adipose tissue metabolism: a [¹⁸F]FDG PET/CT study in mice. Nucl Med Biol (2013) 0.86
Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase. Genes Nutr (2011) 0.86
Brown adipose tissue dynamics in wild-type and UCP1-knockout mice: in vivo insights with magnetic resonance. J Lipid Res (2013) 0.85
ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia. Front Endocrinol (Lausanne) (2013) 0.83
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab (2016) 0.83
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Sci Signal (2015) 0.83
A new role for lipocalin prostaglandin d synthase in the regulation of brown adipose tissue substrate utilization. Diabetes (2012) 0.83
The impact of dietary methionine restriction on biomarkers of metabolic health. Prog Mol Biol Transl Sci (2014) 0.80
Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans. Int J Obes (Lond) (2016) 0.78
Review analysis of the association between the prevalence of activated brown adipose tissue and outdoor temperature. ScientificWorldJournal (2012) 0.78
Cerenkov luminescence imaging of interscapular brown adipose tissue. J Vis Exp (2014) 0.77
Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice. Biochem Biophys Res Commun (2010) 0.77
Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice. Am J Physiol Regul Integr Comp Physiol (2016) 0.76
Dietary fat overload reprograms brown fat mitochondria. Front Physiol (2015) 0.76
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. J Clin Invest (2016) 0.76
The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy. Mol Metab (2016) 0.75
Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation. J Appl Physiol (1985) (2016) 0.75
Regulation of glycolysis in brown adipocytes by HIF-1α. Sci Rep (2017) 0.75
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice. Food Nutr Res (2017) 0.75
Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity. Front Immunol (2017) 0.75
Involvement of thermosensitive TRP channels in energy metabolism. J Physiol Sci (2017) 0.75
Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet (2004) 8.62
Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest (2013) 3.38
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. JAMA (2007) 3.00
Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin Infect Dis (2006) 2.72
Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring) (2010) 2.33
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem J (2003) 2.17
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J Cell Biol (2002) 2.05
Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) (2011) 1.97
Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene. J Rheumatol (2002) 1.88
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol (2013) 1.86
Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab (2012) 1.84
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol (2005) 1.62
Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab (2005) 1.62
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol (2003) 1.58
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
Semi-quantitative analysis of Streptococcus pneumoniae urinary antigen: kinetics of antigen titers and severity of diseases. Scand J Infect Dis (2006) 1.48
Traditional medicine in china, Korea, and Japan: a brief introduction and comparison. Evid Based Complement Alternat Med (2012) 1.46
Factors that influence the applicability of sham needle in acupuncture trials: two randomized, single-blind, crossover trials with acupuncture-experienced subjects. Clin J Pain (2006) 1.35
Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr (2012) 1.19
Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc Res Tech (2002) 1.17
Oseltamivir-resistant influenza a viruses circulating in Japan. J Clin Microbiol (2009) 1.14
Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett (2002) 1.10
Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. Endocrinology (2007) 1.05
Computed tomographic assessment of body fat in beagles. Vet Radiol Ultrasound (2005) 1.03
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS One (2010) 1.02
Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med (2014) 0.99
Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects. Diabetes (2003) 0.97
Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro. Invest Ophthalmol Vis Sci (2009) 0.97
Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin. Proc Natl Acad Sci U S A (2006) 0.96
Expression of uncoupling proteins in human skin and skin-derived cells. J Invest Dermatol (2008) 0.96
Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway. FEBS Lett (2009) 0.96
Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts. Invest Ophthalmol Vis Sci (2005) 0.96
Pneumoperitoneum recurring concomitantly with asthmatic exacerbation. Intern Med (2008) 0.95
Role of central leptin signaling in the starvation-induced alteration of B-cell development. J Neurosci (2011) 0.94
Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem J (2002) 0.92
Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood) (2011) 0.92
Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction. Am J Physiol Heart Circ Physiol (2005) 0.92
Cytokine, chemokine, and adhesion molecule expression mediated by MAPKs in human corneal fibroblasts exposed to poly(I:C). Invest Ophthalmol Vis Sci (2008) 0.92
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding. J Clin Invest (2014) 0.92
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle. Indian J Endocrinol Metab (2012) 0.92
Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant mice. Dev Dyn (2009) 0.91
TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J Appl Physiol (1985) (2011) 0.90
Elevated plasma concentrations of haptoglobin in European brown bears during hibernation. Comp Biochem Physiol A Mol Integr Physiol (2005) 0.89
An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes. Anal Biochem (2011) 0.89
Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci (2012) 0.89
Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats. Diabetes Metab Res Rev (2008) 0.89
Promotion by fibronectin of collagen gel contraction mediated by human corneal fibroblasts. Exp Eye Res (2006) 0.88
Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene (2009) 0.87
Remodeling excitation-contraction coupling of hypertrophied ventricular myocytes is dependent on T-type calcium channels expression. Biochem Biophys Res Commun (2006) 0.87
Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes. Domest Anim Endocrinol (2006) 0.87
Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1). J Mol Histol (2005) 0.86
Down regulation of hepatic PPARalpha function by AhR ligand. J Vet Med Sci (2004) 0.85
[Case of pulmonary aspergillosis associated with inappropriate antidiuretic hormone syndrome caused by voriconazole therapy]. Nihon Kokyuki Gakkai Zasshi (2007) 0.85
Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells. Biochem J (2003) 0.85
Correlation between plasma leptin concentration and body fat content in dogs. Am J Vet Res (2002) 0.84
Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4. J Vet Med Sci (2002) 0.84
Hepatocyte growth factor/scatter factor suppresses TNF-alpha-induced E-selectin expression in human umbilical vein endothelial cells. Biochim Biophys Acta (2004) 0.84
Chymase participates in chronic dermatitis by inducing eosinophil infiltration. Lab Invest (2002) 0.84
Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue. Biomed Res (2009) 0.83
Induction of Src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide. J Histochem Cytochem (2002) 0.83
The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs. Br J Nutr (2007) 0.83
Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Invest Ophthalmol Vis Sci (2005) 0.83
Role of mast cell chymase in allergen-induced biphasic skin reaction. Biochem Pharmacol (2002) 0.83
Quality of life after lung cancer surgery: video-assisted thoracic surgery versus thoracotomy. Heart Lung Circ (2007) 0.83
Inhibition by medroxyprogesterone acetate of interleukin-1β-induced collagen degradation by corneal fibroblasts. Invest Ophthalmol Vis Sci (2012) 0.83
Coronary-prone behavior among Japanese men. Circ J (2003) 0.83
Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues. Endocr J (2013) 0.83
Experimental and clinical studies on plasma leptin in obese dogs. J Vet Med Sci (2002) 0.83
Promotion of corneal epithelial wound healing in vitro and in vivo by annexin A5. Invest Ophthalmol Vis Sci (2006) 0.83
[An autopsy case of obliterative bronchiolitis associated with Stevens-Johnson syndrome]. Nihon Kokyuki Gakkai Zasshi (2006) 0.82
Relationships of differential leukocyte and lymphocyte subpopulations with carotid atherosclerosis in elderly men. J Clin Immunol (2003) 0.82
Inhibition by female sex hormones of collagen degradation by corneal fibroblasts. Mol Vis (2011) 0.82
Meta-analysis of the results of intravenous gamma globulin treatment of coronary artery lesions in Kawasaki disease. Mod Rheumatol (2004) 0.82
Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice. Am J Physiol Endocrinol Metab (2006) 0.82
Inhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci (2005) 0.82
The expression of src-suppressed C kinase substrate (SSeCKS) and uptake of exogenous particles in endothelial and reticular cells. Arch Histol Cytol (2004) 0.82
Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am J Physiol Endocrinol Metab (2005) 0.81
[Evaluation of an immunochromatography test using enzyme immunoassay for rapid detection of influenza A and B viruses]. Kansenshogaku Zasshi (2004) 0.81
[A case of falciparum malaria successfully treated with intravenous artesunate]. Kansenshogaku Zasshi (2002) 0.81
Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. Pflugers Arch (2006) 0.81
Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A (2007) 0.81
Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin. J Nutr Sci Vitaminol (Tokyo) (2004) 0.81