Published in J Clin Invest on May 01, 2005
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia | NCT01082588
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol (2005) 8.49
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature (2007) 6.53
Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One (2010) 6.48
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66
Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol (2008) 5.61
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A (2007) 3.76
Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res (2008) 3.47
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30
Angiogenesis modulates adipogenesis and obesity. J Clin Invest (2007) 3.23
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12
Inflamed fat: what starts the fire? J Clin Invest (2006) 3.11
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A (2006) 3.02
Retracted Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol (2011) 3.02
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev (2008) 2.96
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A (2006) 2.88
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology (2006) 2.82
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Inflammatory mechanisms in the regulation of insulin resistance. Mol Med (2008) 2.71
Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest (2011) 2.62
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest (2008) 2.58
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell (2009) 2.57
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest (2008) 2.55
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes (2008) 2.42
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci U S A (2006) 2.41
Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care (2010) 2.39
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest (2009) 2.39
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: a systematic review. Evid Based Complement Alternat Med (2007) 2.35
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell (2007) 2.35
Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes (2011) 2.29
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22
A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology (2012) 2.21
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab (2013) 2.20
Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLoS Med (2007) 2.17
Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J Gastroenterol (2008) 2.17
High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One (2012) 2.17
Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16
Retracted Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis. Hepatology (2013) 2.16
Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem (2009) 2.11
Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes Care (2011) 2.10
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A (2010) 2.10
Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care (2012) 2.09
Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med (2010) 2.07
Effects of obesity on bone metabolism. J Orthop Surg Res (2011) 2.06
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes (2007) 2.01
The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00
Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol (2012) 1.99
Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes (Lond) (2008) 1.98
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci U S A (2009) 1.97
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab (2008) 1.96
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res (2006) 1.95
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med (2008) 1.94
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med (2010) 1.93
The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93
Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol (2010) 1.92
Current views on type 2 diabetes. J Endocrinol (2009) 1.88
Inflammatory lipid mediators in adipocyte function and obesity. Nat Rev Endocrinol (2010) 1.87
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metab (2014) 1.86
Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats. Free Radic Biol Med (2007) 1.84
Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes (2011) 1.82
L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice. J Lipid Res (2008) 1.80
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proc Natl Acad Sci U S A (2009) 1.79
Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS One (2011) 1.77
Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids (2008) 1.76
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia (2011) 1.76
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun (2015) 1.75
Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation (2008) 1.73
Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm (Lond) (2010) 1.73
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology (2006) 1.72
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology (2011) 1.71
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol (2012) 1.70
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab (2009) 1.69
Gestational diabetes and preeclampsia in association with air pollution at levels below current air quality guidelines. Environ Health Perspect (2013) 1.69
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes (2009) 1.67
The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol (2009) 1.66
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest (2006) 1.66
Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm (2010) 1.65
Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev (2011) 1.65
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem (2009) 1.60
The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol (2013) 1.59
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.59
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Signal transduction by the JNK group of MAP kinases. Cell (2000) 18.24
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50
Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 13.42
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem (1995) 13.34
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med (2005) 10.88
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 10.53
Mitochondrial dysfunction and type 2 diabetes. Science (2005) 10.25
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature (1998) 10.09
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest (1995) 9.59
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell (1998) 7.91
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol (2004) 6.78
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (1998) 6.69
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes (1998) 6.53
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med (2003) 6.21
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med (2001) 6.09
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell (2001) 5.76
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med (2001) 5.74
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem (2001) 5.12
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest (2002) 4.96
Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care (2004) 4.88
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem (2002) 4.84
Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res (2004) 4.67
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab (2002) 4.64
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation (2003) 4.52
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med (2004) 4.29
LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell (2004) 4.20
Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science (2003) 3.97
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem (2004) 3.94
Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem (2003) 3.91
Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol (2003) 3.89
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem (2002) 3.83
Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology (2003) 3.83
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol (2004) 3.79
The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet (2003) 3.67
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63
Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol (2002) 3.59
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab (2005) 3.51
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature (1998) 3.48
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest (1995) 3.39
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med (2001) 3.14
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem (2001) 3.09
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes (2005) 3.00
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell (2003) 2.99
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med (2004) 2.98
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord (2003) 2.89
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med (2004) 2.82
Insulin signaling pathways in time and space. Trends Cell Biol (2002) 2.74
The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest (1996) 2.73
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol (2004) 2.68
An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest (1997) 2.45
The insulin signalling system and the IRS proteins. Diabetologia (1997) 2.44
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science (2004) 2.38
A role for preadipocytes as macrophage-like cells. FASEB J (1999) 2.24
The current biology of resistin. J Intern Med (2004) 2.06
NF-kappaB and the innate immune response. Curr Opin Immunol (2000) 2.04
Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. J Nutr (2004) 2.00
Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem (2004) 1.99
Chronic obstructive pulmonary disease, asthma, and risk of type 2 diabetes in women. Diabetes Care (2004) 1.98
Are patients with asthma at increased risk of coronary heart disease? Int J Epidemiol (2004) 1.97
The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol (1999) 1.95
Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J Biol Chem (2004) 1.86
Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord (2003) 1.85
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology (2002) 1.80
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest (2004) 1.79
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2004) 1.74
Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes (2001) 1.71
Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem (2003) 1.67
Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. J Biol Chem (2001) 1.67
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet (2000) 1.65
Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord (2003) 1.53
Genetics and pathophysiology of human obesity. Annu Rev Med (2001) 1.49
Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival. Proc Natl Acad Sci U S A (1996) 1.41
Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J Clin Invest (1978) 1.35
Tumor necrosis factor-alpha-induced insulin resistance may mediate the hepatitis C virus-diabetes association. Am J Gastroenterol (2003) 1.33
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev (2004) 1.32
The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet (2003) 1.31
Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Ann N Y Acad Sci (2002) 1.29
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest (1997) 1.29
Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am J Clin Nutr (1980) 1.29
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 9.83
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature (2007) 4.59
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res (2007) 3.96
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab (2005) 3.51
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A (2006) 3.02
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest (2008) 2.55
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation (2003) 2.52
Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med (2010) 2.48
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell (2007) 2.35
Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res (2010) 2.20
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab (2012) 2.04
Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. J Nutr (2004) 2.00
Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology (2006) 1.97
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol (2002) 1.94
Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Biol (2005) 1.92
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One (2008) 1.90
Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes (2003) 1.88
The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol (2011) 1.87
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology (2002) 1.80
Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. Clin Chem (2003) 1.70
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature (2013) 1.69
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation (2004) 1.60
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A (2011) 1.59
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes (2006) 1.56
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. Am J Clin Nutr (2010) 1.55
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med (2013) 1.55
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest (2006) 1.54
The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol (2005) 1.53
Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes (2013) 1.50
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res (2003) 1.34
Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol (2006) 1.31
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26
Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol (2003) 1.25
Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol (2007) 1.25
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab (2013) 1.19
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes (2002) 1.19
Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. PLoS One (2011) 1.13
Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology (2004) 1.09
The role of JNK proteins in metabolism. Sci Transl Med (2010) 1.09
Linking the inflammasome to obesity-related disease. Nat Med (2011) 1.05
Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metab (2003) 1.02
Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet (2012) 1.01
FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes (2013) 0.98
Stressing the brain, fattening the body. Cell (2008) 0.96
Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol (2013) 0.95
The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep (2013) 0.95
Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. Curr Atheroscler Rep (2007) 0.93
Turning off the inflammatory, but not the metabolic, flames. Nat Med (2013) 0.93
Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes. Arterioscler Thromb Vasc Biol (2011) 0.93
Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol (2002) 0.92
Metabolism: Host and microbes in a pickle. Nature (2010) 0.89
Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol (2013) 0.87
Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab (2012) 0.86
Developmental biology: cell fate in the mammary gland. Nature (2007) 0.85
GATA transcription factors and fat cell formation. Drug News Perspect (2003) 0.85
Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol (2006) 0.85
Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization. Cell Metab (2013) 0.84
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One (2013) 0.83
Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem (2012) 0.83
Impact of ER protein homeostasis on metabolism. Diabetes (2013) 0.82
The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep (2005) 0.82
Promoting atherosclerosis in type 1 diabetes through the selective activation of arachidonic acid and PGE(2) production. Circ Res (2012) 0.76
Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med (2017) 0.75