Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.

PubWeight™: 5.95‹?› | Rank: Top 1%

🔗 View Article (PMID 15886381)

Published in JAMA on May 11, 2005

Authors

Heike A Bischoff-Ferrari1, Walter C Willett, John B Wong, Edward Giovannucci, Thomas Dietrich, Bess Dawson-Hughes

Author Affiliations

1: Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA. hbischof@hsph.harvard.edu

Associated clinical trials:

Prevention of Falls and Fractures in Old People by Administration of Calcium and Vitamin D. Randomized Clinical Trial (ANVITAD) | NCT01452243

Study Comparing Bone Loss in Women Who Take Calcium and Vitamin D With Women Who Also Take Risedronate or Exercise (HOPE) | NCT02186600

Vitamin D and Osteoporosis Prevention in Elderly African American Women (NIHD) | NCT01153568

Articles citing this

(truncated to the top 100)

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (2014) 7.21

Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med (2010) 5.20

Effect of calcium supplementation on hip fractures. Osteoporos Int (2008) 2.79

IOF position statement: vitamin D recommendations for older adults. Osteoporos Int (2010) 2.79

Skeletal and nonskeletal effects of vitamin D: is vitamin D a tonic for bone and other tissues? Osteoporos Int (2014) 2.74

Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ (2010) 2.67

Calcium intake and risk of fracture: systematic review. BMJ (2015) 2.60

Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res (2011) 2.55

Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging (2008) 2.54

Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med (2008) 2.44

Vitamin D for health: a global perspective. Mayo Clin Proc (2013) 2.41

African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. Am J Clin Nutr (2008) 2.37

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract (2011) 2.29

Vitamin D in health and disease. Clin J Am Soc Nephrol (2008) 2.24

Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol (2010) 2.14

Vitamin D deficiency in older men. J Clin Endocrinol Metab (2009) 2.13

Not enough vitamin D: health consequences for Canadians. Can Fam Physician (2007) 2.03

Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int (2008) 1.97

Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. J Neurol (2007) 1.92

Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk--a meta-analysis. Osteoporos Int (2006) 1.79

Osteoporosis and its management. BMJ (2006) 1.75

Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res (2009) 1.66

Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab (2008) 1.65

Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc (2010) 1.60

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada (summary). CMAJ (2010) 1.59

Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts. Br J Nutr (2012) 1.59

Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab (2010) 1.58

Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol (2008) 1.53

One-year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol (2010) 1.49

Validation of a 4-item score predicting hip fracture and mortality risk among elderly women. Ann Fam Med (2007) 1.48

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ (2010) 1.45

Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. Eur J Clin Nutr (2009) 1.42

Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci (2009) 1.40

25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology (2009) 1.40

Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res (2010) 1.35

Vitamin D in health and disease: current perspectives. Nutr J (2010) 1.31

Autocrine and paracrine actions of vitamin d. Clin Biochem Rev (2010) 1.26

Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. PLoS One (2009) 1.25

Vitamin D: The "sunshine" vitamin. J Pharmacol Pharmacother (2012) 1.24

Advances in the prevention of Alzheimer's disease and dementia. J Intern Med (2014) 1.23

High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int (2008) 1.20

Vitamin D and bone health in adults with cystic fibrosis. Clin Endocrinol (Oxf) (2008) 1.20

Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am (2010) 1.18

Vitamin D metabolism and action in human bone marrow stromal cells. Endocrinology (2009) 1.16

High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab (2011) 1.15

Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects. J Neuroeng Rehabil (2010) 1.14

Progress in developing analytical and label-based dietary supplement databases at the NIH Office of Dietary Supplements. J Food Compost Anal (2008) 1.13

Prevention of osteoporosis-related fractures among postmenopausal women and older men. CMAJ (2009) 1.12

Metabolic complications and treatment of perinatally HIV-infected children and adolescents. J Int AIDS Soc (2013) 1.09

Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int (2007) 1.09

Vitamin D and bone. Curr Osteoporos Rep (2012) 1.08

How to select the doses of vitamin D in the management of osteoporosis. Osteoporos Int (2006) 1.08

Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res (2009) 1.08

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies. BMC Public Health (2010) 1.07

Calcium and vitamin D intake influence bone mass, but not short-term fracture risk, in Caucasian postmenopausal women from the National Osteoporosis Risk Assessment (NORA) study. Osteoporos Int (2007) 1.06

The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml. Osteoporos Int (2012) 1.05

The clinical epidemiology of male osteoporosis: a review of the recent literature. Clin Epidemiol (2015) 1.05

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int (2012) 1.05

PILL Series. Vitamin D deficiency. Singapore Med J (2015) 1.05

Discriminants of prevalent fractures in chronic kidney disease. J Am Soc Nephrol (2011) 1.05

Mechanisms underlying the effect of vitamin D on the immune system. Proc Nutr Soc (2010) 1.04

Significant 25-hydroxyvitamin D deficiency in child and adolescent survivors of acute lymphoblastic leukemia: treatment with chemotherapy compared with allogeneic stem cell transplant. Pediatr Blood Cancer (2010) 1.04

Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Osteoporos Int (2008) 1.03

Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs (2011) 1.03

The biology and pathology of vitamin D control in bone. J Cell Biochem (2010) 1.03

Recommended intakes of vitamin D to optimise health, associated circulating 25-hydroxyvitamin D concentrations, and dosing regimens to treat deficiency: workshop report and overview of current literature. J Nutr Sci (2015) 1.02

Why randomized controlled trials of calcium and vitamin D sometimes fail. Dermatoendocrinol (2012) 1.02

Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence. BMC Geriatr (2011) 1.00

Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K. Eur J Epidemiol (2008) 1.00

Adiposity and genetic admixture, but not race/ethnicity, influence bone mineral content in peripubertal children. J Bone Miner Metab (2010) 0.99

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int (2009) 0.99

Effectiveness of antiresorptive agents in the prevention of recurrent hip fractures. Osteoporos Int (2007) 0.99

Vitamin D and bone disease. Biomed Res Int (2012) 0.98

An interdisciplinary knowledge translation intervention in long-term care: study protocol for the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial. Implement Sci (2012) 0.98

User-centered development of a smart phone mobile application delivering personalized real-time advice on sun protection. Transl Behav Med (2013) 0.97

Bisphosphonates and osteoporotic fractures: a cross-design synthesis of results among compliant/persistent postmenopausal women in clinical practice versus randomized controlled trials. Osteoporos Int (2009) 0.97

Evidence-based guidelines for the pharmacological treatment of postmenopausal osteoporosis: a consensus document by the Belgian Bone Club. Osteoporos Int (2010) 0.97

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women. Nutr Res (2009) 0.97

Experimental evidence for the effects of calcium and vitamin D on bone: a review. Nutrients (2010) 0.96

Whole bone mechanics and bone quality. Clin Orthop Relat Res (2011) 0.95

Hip fractures in a city in Northern Norway over 15 years: time trends, seasonal variation and mortality : the Harstad Injury Prevention Study. Osteoporos Int (2011) 0.95

A scoping review of strategies for the prevention of hip fracture in elderly nursing home residents. PLoS One (2010) 0.95

Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures. J Bone Miner Res (2008) 0.95

Prevention and clinical management of hip fractures in patients with dementia. Geriatr Orthop Surg Rehabil (2010) 0.94

Evaluation of a fall-prevention program in older people after femoral neck fracture: a one-year follow-up. Osteoporos Int (2008) 0.94

Life-course approach to nutrition. Osteoporos Int (2015) 0.94

Reporting of systematic reviews of micronutrients and health: a critical appraisal. Am J Clin Nutr (2009) 0.93

Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D. Osteoporos Int (2012) 0.93

The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol (2013) 0.92

Optimal Vitamin D Supplementation Doses that Minimize the Risk for Both Low and High Serum 25-Hydroxyvitamin D Concentrations in the General Population. Nutrients (2015) 0.92

Osteoanabolics. Indian J Endocrinol Metab (2012) 0.92

Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults. Eur J Epidemiol (2013) 0.91

Age, race and season predict vitamin D status in African American and white octogenarians and centenarians. J Nutr Health Aging (2008) 0.91

Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study. J Am Geriatr Soc (2012) 0.90

Associations between vitamin D status and pain in older adults: the Invecchiare in Chianti study. J Am Geriatr Soc (2008) 0.90

Female asylum seekers with musculoskeletal pain: the importance of diagnosis and treatment of hypovitaminosis D. BMC Fam Pract (2006) 0.90

The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis. BMC Musculoskelet Disord (2007) 0.90

Diagnosis and management of osteoporosis in the older senior. Clin Interv Aging (2009) 0.90

Articles by these authors

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 50.94

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18

Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65

Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res (2007) 14.84

Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34

Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med (2011) 12.29

Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA (2004) 11.69

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr (2006) 10.95

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis (2013) 10.92

Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA (2003) 10.05

The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab (2007) 8.91

Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst (2004) 8.77

Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med (2004) 8.63

Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care (2010) 8.52

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39

Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med (2013) 7.72

The public health and economic benefits of taxing sugar-sweetened beverages. N Engl J Med (2009) 7.48

Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med (2012) 7.47

Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32

Optimal diets for prevention of coronary heart disease. JAMA (2002) 7.24

Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19

Estimates of optimal vitamin D status. Osteoporos Int (2005) 7.13

Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension (2007) 6.99

Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96

Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology (2008) 6.87

A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med (2012) 6.85

Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr (2005) 6.67

Trans fatty acids and cardiovascular disease. N Engl J Med (2006) 6.67

Effect of Vitamin D on falls: a meta-analysis. JAMA (2004) 6.64

Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med (2014) 6.51

Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98

Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med (2003) 5.95

Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr (2009) 5.79

Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med (2004) 5.67

Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med (2009) 5.63

Alternative dietary indices both strongly predict risk of chronic disease. J Nutr (2012) 5.60

Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med (2005) 5.59

Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C. Hepatology (2003) 5.40

The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care (2007) 5.07

Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA (2013) 5.05

Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med (2012) 4.72

Exercise type and intensity in relation to coronary heart disease in men. JAMA (2002) 4.69

Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care (2006) 4.62

Meta-analysis: the effect of dietary counseling for weight loss. Ann Intern Med (2007) 4.54

Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care (2002) 4.48

Habitual caffeine intake and the risk of hypertension in women. JAMA (2005) 4.46

Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc (2003) 4.44

Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med (2003) 4.40

The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr (2007) 4.36

Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr (2004) 4.29

Dietary patterns, meat intake, and the risk of type 2 diabetes in women. Arch Intern Med (2004) 4.27

Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA (2011) 4.25

Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men. Circulation (2012) 4.24

Frequency of analgesic use and risk of hypertension in younger women. Arch Intern Med (2002) 4.21

Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med (2002) 4.19

Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med (2006) 4.16

A new proposed guidance system for beverage consumption in the United States. Am J Clin Nutr (2006) 4.12

Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol (2007) 4.11

A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis. Gastroenterology (2013) 4.06

Comparison of risk factors for colon and rectal cancer. Int J Cancer (2004) 4.03

Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut (2010) 4.01

High school dietary dairy intake and teenage acne. J Am Acad Dermatol (2005) 4.00

Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst (2006) 3.96

Association of nut consumption with total and cause-specific mortality. N Engl J Med (2013) 3.94

Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr (2009) 3.90

Estimating the number of deaths due to obesity: can the divergent findings be reconciled? J Womens Health (Larchmt) (2007) 3.86

Trends in 24-h urinary sodium excretion in the United States, 1957-2003: a systematic review. Am J Clin Nutr (2010) 3.84

Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr (2013) 3.83

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81

Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer (2007) 3.77

Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr (2004) 3.76

Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med (2015) 3.75

Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA (2002) 3.68

Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut (2012) 3.67

Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med (2010) 3.66

The association between a nutritional quality index and risk of chronic disease. Am J Prev Med (2011) 3.66

Major dietary protein sources and risk of coronary heart disease in women. Circulation (2010) 3.65

Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA (2002) 3.60

Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr (2005) 3.55

Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst (2003) 3.54

A prospective study of aspirin use and the risk of pancreatic cancer in women. J Natl Cancer Inst (2004) 3.49

Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation (2009) 3.47