Published in EMBO J on May 05, 2005
G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci (2008) 2.05
Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc Natl Acad Sci U S A (2007) 2.02
Assembly and trafficking of heterotrimeric G proteins. Biochemistry (2007) 1.98
The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol (2009) 1.97
Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal (2011) 1.32
Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding. Cell Signal (2007) 1.30
The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nat Struct Mol Biol (2008) 1.29
Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Proc Natl Acad Sci U S A (2013) 1.21
Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proc Natl Acad Sci U S A (2006) 1.07
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Mol Biol Cell (2007) 1.06
Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. J Biol Chem (2011) 1.04
The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei. BMC Genomics (2011) 1.00
The phosducin-like protein PhLP1 is essential for G{beta}{gamma} dimer formation in Dictyostelium discoideum. Mol Cell Biol (2005) 1.00
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest (2009) 0.98
Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival. Mol Cell Proteomics (2010) 0.96
The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans. Eukaryot Cell (2006) 0.92
Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding. J Biol Chem (2013) 0.90
G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits. J Biol Chem (2011) 0.89
Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. J Biol Chem (2009) 0.89
G protein-coupled receptors: what a difference a 'partner' makes. Int J Mol Sci (2014) 0.86
Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors. J Neurosci (2013) 0.85
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. J Biol Chem (2013) 0.84
Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding. J Amino Acids (2011) 0.84
Chaperones contribute to G protein coupled receptor oligomerization, but do not participate in assembly of the G protein with the receptor signaling complex. J Mol Signal (2010) 0.79
The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis. Mol Microbiol (2007) 0.79
Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. J Biol Chem (2013) 0.79
Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution. Proc Natl Acad Sci U S A (2015) 0.78
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature (2017) 0.78
Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Proc Natl Acad Sci U S A (2015) 0.77
Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica. Mol Microbiol (2010) 0.77
Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. Elife (2015) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Seven-transmembrane-spanning receptors and heart function. Nature (2002) 5.38
Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci (2004) 4.44
G proteins and phototransduction. Annu Rev Physiol (2002) 3.74
G protein beta gamma subunits. Annu Rev Pharmacol Toxicol (1997) 3.50
Structure-based assembly of protein complexes in yeast. Science (2004) 2.89
Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88
Imaging the hierarchical Ca2+ signalling system in HeLa cells. J Physiol (1997) 2.60
Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell (1996) 2.49
Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT. FEBS Lett (2002) 1.92
The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20. Mol Cell (2003) 1.81
Assembly-controlled regulation of chloroplast gene translation. Biochem Soc Trans (2001) 1.56
Phosducin is a protein kinase A-regulated G-protein regulator. Nature (1992) 1.55
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Mol Biol Cell (2002) 1.48
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J (2002) 1.42
Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell (2003) 1.37
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc Natl Acad Sci U S A (2002) 1.35
The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin. J Biol Chem (1994) 1.31
Regulation of retinal cGMP cascade by phosducin in bovine rod photoreceptor cells. Interaction of phosducin and transducin. J Biol Chem (1992) 1.19
Identification of bdm-1, a gene involved in G protein beta-subunit function and alpha-subunit accumulation. Proc Natl Acad Sci U S A (2000) 1.17
Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc Natl Acad Sci U S A (1993) 1.17
Functional roles of the two domains of phosducin and phosducin-like protein. J Biol Chem (2000) 1.14
Structure of the complex between the cytosolic chaperonin CCT and phosducin-like protein. Proc Natl Acad Sci U S A (2004) 1.14
The immunolocalization and divergent roles of phosducin and phosducin-like protein in the retina. Mol Vis (1999) 1.07
Interaction of phosducin-like protein with G protein betagamma subunits. J Biol Chem (1997) 1.07
Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. J Biol Chem (2000) 1.07
Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins. EMBO J (2003) 1.05
Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. J Biol Chem (2005) 1.04
A novel step in beta-tubulin folding is important for heterodimer formation in Saccharomyces cerevisiae. Genetics (2003) 0.98
Quantification of the tissue levels and function of the G-protein regulator phosducin-like protein (PhlP). Naunyn Schmiedebergs Arch Pharmacol (2000) 0.90
Regulation of angiotensin II-induced G protein signaling by phosducin-like protein. J Biol Chem (2002) 0.90
Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like protein. Biochemistry (2004) 0.90
Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry. J Biomol Tech (2004) 0.84
Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing. J Biol Chem (2002) 0.84
Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain. Neuropharmacology (2002) 0.83
Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol (2008) 5.30
Insights into G protein structure, function, and regulation. Endocr Rev (2003) 3.33
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nat Struct Mol Biol (2006) 2.68
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proc Natl Acad Sci U S A (2011) 2.10
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem (2005) 2.09
Structural basis of function in heterotrimeric G proteins. Q Rev Biophys (2006) 1.94
G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nat Neurosci (2005) 1.69
Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nat Neurosci (2005) 1.65
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci (2006) 1.58
A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol (2014) 1.46
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc Natl Acad Sci U S A (2002) 1.35
Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proc Natl Acad Sci U S A (2006) 1.33
Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med (2006) 1.31
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem (2006) 1.27
RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons. Proc Natl Acad Sci U S A (2004) 1.26
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem (2002) 1.24
2-(4-Bromo-phen-oxy)-3-isopropyl-5,6,7,8-tetra-hydro-1-benzothieno[2,3-d]pyrimidin-4(3H)-one. Acta Crystallogr Sect E Struct Rep Online (2008) 1.22
Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. Blood (2005) 1.20
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J (2009) 1.18
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proc Natl Acad Sci U S A (2007) 1.17
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol (2009) 1.15
DEP domains: More than just membrane anchors. Dev Cell (2006) 1.14
Structure of the complex between the cytosolic chaperonin CCT and phosducin-like protein. Proc Natl Acad Sci U S A (2004) 1.14
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol (2007) 1.13
Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins. J Mol Cell Cardiol (2004) 1.12
Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex. J Biol Chem (2006) 1.12
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell (2008) 1.11
Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation. Biochemistry (2002) 1.10
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nat Genet (2013) 1.09
Knowledge about cervical cancer and barriers of screening program among women in Wufeng County, a high-incidence region of cervical cancer in China. PLoS One (2013) 1.08
Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes. J Biol Chem (2002) 1.08
RACK1 regulates specific functions of Gbetagamma. J Biol Chem (2004) 1.08
Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction. Biophys J (2008) 1.07
Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. Mol Pharmacol (2007) 1.07
Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective. J Mol Biol (2013) 1.05
Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. Curr Opin Genet Dev (2006) 1.05
G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling. Sci STKE (2002) 1.03
Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study. Crit Care (2013) 1.03
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. J Biol Chem (2005) 1.02
Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. J Biol Chem (2002) 1.02
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J Biol Chem (2005) 1.01
Changes in prevalence and clinical characteristics of cervical cancer in the People's Republic of China: a study of 10,012 cases from a nationwide working group. Oncologist (2013) 1.01
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci Signal (2010) 1.01
Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Mol Pharmacol (2006) 1.00
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol (2010) 0.99
An integrated intervention program to control diabetes in overweight Chinese women and men with type 2 diabetes. Asia Pac J Clin Nutr (2008) 0.99
How do receptors activate G proteins? Adv Protein Chem (2007) 0.99
G protein signaling: insights from new structures. Sci STKE (2004) 0.98
GPCR mediated regulation of synaptic transmission. Prog Neurobiol (2012) 0.98
Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer binding. J Biol Chem (2004) 0.97
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry (2009) 0.97
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem (2005) 0.97
Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling. J Biol Chem (2003) 0.97
Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not. Mutat Res (2012) 0.97
Modeling the role of incisures in vertebrate phototransduction. Biophys J (2006) 0.96
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone--induced apoptosis in leukemia k562 cells and its mechanisms of action. Int J Toxicol (2009) 0.94
Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. BMC Med Genomics (2012) 0.94
The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway. Hum Pathol (2013) 0.94
Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One (2012) 0.93
G protein betagamma subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry. J Neurophysiol (2008) 0.93
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets. Mol Pharmacol (2013) 0.93
Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod photoresponse. PLoS Comput Biol (2010) 0.93
The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution. Biochemistry (2003) 0.93
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins. Biochemistry (2008) 0.93
Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. Methods Enzymol (2002) 0.92
Microring-based ratio-metric wavelength monitor on silicon. Opt Lett (2014) 0.92
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2. J Biol Chem (2002) 0.92
A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. J Biol Chem (2003) 0.91
Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (2013) 0.91
G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. Proc Natl Acad Sci U S A (2006) 0.90
Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like protein. Biochemistry (2004) 0.90
Regulation of angiotensin II-induced G protein signaling by phosducin-like protein. J Biol Chem (2002) 0.90
Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding. J Biol Chem (2013) 0.90
Ultrasonic gene and drug delivery using eLiposomes. J Control Release (2013) 0.90
BaNbO(IO3)5: a new polar material with a very large SHG response. J Am Chem Soc (2009) 0.89
HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by α-1-antitrypsin through altered IκBα ubiquitination. J Immunol (2011) 0.89
Coupling efficiency of rhodopsin and transducin in bicelles. Biochemistry (2011) 0.89
Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol Pharmacol (2009) 0.89
Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. J Biol Chem (2009) 0.89
Dendritic molecular transporters provide control of delivery to intracellular compartments. Bioconjug Chem (2007) 0.88
HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One (2012) 0.88
Identification of key factors that reduce the variability of the single photon response. Proc Natl Acad Sci U S A (2011) 0.88
Adjuvant chemotherapy, a valuable alternative option in selected patients with cervical cancer. PLoS One (2013) 0.87
Multifactor dimensionality reduction reveals a three-locus epistatic interaction associated with susceptibility to pulmonary tuberculosis. BioData Min (2013) 0.87
NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. Proc Natl Acad Sci U S A (2009) 0.86
Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. Mutat Res (2009) 0.86
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry (2012) 0.86
Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. PLoS One (2013) 0.86
[Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma]. Chin J Cancer (2010) 0.86
Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci (2014) 0.85
Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors. J Neurosci (2013) 0.85
Low-chirp high-extinction-ratio modulator based on graphene-silicon waveguide. Opt Lett (2013) 0.84
Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry. J Biomol Tech (2004) 0.84
Ultracompact optical modulator based on graphene-silica metamaterial. Opt Lett (2014) 0.83
Ultra-performance liquid chromatography-tandem mass spectrometry determination and depletion profile of flunixin residues in tissues after single oral administration in rabbits. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.82