Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity.

PubWeight™: 3.75‹?› | Rank: Top 1%

🔗 View Article (PMC 2171694)

Published in J Cell Biol on May 16, 2005

Authors

Clare L Bennett1, Erwin van Rijn, Steffen Jung, Kayo Inaba, Ralph M Steinman, Martien L Kapsenberg, Björn E Clausen

Author Affiliations

1: Department of Cell Biology and Histology, Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

Articles citing this

(truncated to the top 100)

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med (2010) 4.56

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol (2009) 4.51

Identification of a novel population of Langerin+ dendritic cells. J Exp Med (2007) 4.13

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med (2008) 3.97

Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity (2008) 3.94

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med (2007) 3.64

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med (2007) 3.24

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77

Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol (2009) 2.76

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol (2012) 2.62

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44

Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol (2008) 2.41

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40

Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. J Exp Med (2006) 2.18

Dendritic cell control of tolerogenic responses. Immunol Rev (2011) 2.13

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12

Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med (2013) 1.99

Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization. Immunity (2006) 1.95

Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 1.93

Resident and "inflammatory" dendritic cells in human skin. J Invest Dermatol (2008) 1.72

In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol (2010) 1.71

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci U S A (2011) 1.69

Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med (2007) 1.68

CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol (2007) 1.64

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest (2010) 1.64

Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) 1.60

Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol (2009) 1.59

Natural killer cells: walking three paths down memory lane. Trends Immunol (2013) 1.57

Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol (2012) 1.54

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine. J Exp Med (2014) 1.52

Langerhans cells are negative regulators of the anti-Leishmania response. J Exp Med (2011) 1.49

Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci U S A (2011) 1.47

Acute ablation of Langerhans cells enhances skin immune responses. J Immunol (2010) 1.47

Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207. J Immunol Methods (2007) 1.40

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods (2012) 1.40

Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest (2013) 1.33

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J Clin Invest (2011) 1.33

Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity. J Invest Dermatol (2010) 1.31

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci U S A (2013) 1.24

Vaginal epithelial dendritic cells renew from bone marrow precursors. Proc Natl Acad Sci U S A (2007) 1.21

DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance. Photochem Photobiol (2008) 1.18

A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One (2013) 1.17

Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells. J Virol (2006) 1.14

Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J Immunol (2009) 1.12

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest (2012) 1.11

Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. J Immunol (2008) 1.11

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest (2012) 1.09

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome. J Exp Med (2011) 1.09

Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology (2008) 1.08

Flk2+ myeloid progenitors are the main source of Langerhans cells. Blood (2005) 1.07

Langerhans cells as targets for immunotherapy against skin cancer. Immunol Cell Biol (2010) 1.06

Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis. J Allergy Clin Immunol (2012) 1.05

ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells. J Immunol (2011) 1.02

Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation. Cancer Res (2009) 1.02

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci U S A (2012) 1.02

Langerhans cells are not required for graft-versus-host disease. Blood (2010) 1.01

Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines. Hum Immunol (2009) 1.00

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol (2012) 0.98

Roles for IL-1 and TNFalpha in dynamic behavioral responses of Langerhans cells to topical hapten application. J Dermatol Sci (2006) 0.98

A two-step model for Langerhans cell migration to skin-draining LN. Eur J Immunol (2008) 0.97

MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo. PLoS One (2009) 0.97

Lentivirus as a potent and mechanistically distinct vector for genetic immunization. Curr Opin Mol Ther (2007) 0.97

Functions of the aryl hydrocarbon receptor in the skin. Semin Immunopathol (2013) 0.95

Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. J Invest Dermatol (2014) 0.95

TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology (2009) 0.94

Langerhans cells down-regulate inflammation-driven alveolar bone loss. Proc Natl Acad Sci U S A (2012) 0.93

Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med (2015) 0.92

Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses. Front Immunol (2015) 0.92

Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol (2009) 0.91

A new view on cutaneous dendritic cell subsets in experimental leishmaniasis. Med Microbiol Immunol (2006) 0.90

The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells. J Invest Dermatol (2014) 0.90

Foxp3+ regulatory T cells are required for recovery from severe sepsis. PLoS One (2013) 0.88

Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors. J Immunol (2011) 0.88

Role of Th17 cells in skin inflammation of allergic contact dermatitis. Clin Dev Immunol (2013) 0.88

The evolving function of Langerhans cells in adaptive skin immunity. Immunol Cell Biol (2010) 0.87

Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis. PLoS Pathog (2015) 0.87

Langerhans cells serve as immunoregulatory cells by activating NKT cells. J Immunol (2010) 0.86

Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis. J Invest Dermatol (2015) 0.86

Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin. Blood (2011) 0.86

The Langerhans cell controversy: are they immunostimulatory or immunoregulatory cells of the skin immune system? Immunol Cell Biol (2010) 0.86

Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity. J Invest Dermatol (2010) 0.85

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming. J Immunol (2014) 0.85

Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. J Dermatol Sci (2012) 0.84

Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation. J Invest Dermatol (2013) 0.84

The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med (2009) 0.83

Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J Clin Invest (2012) 0.83

Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. PLoS One (2012) 0.83

Dendritic cells in the periphery control antigen-specific natural and induced regulatory T cells. Front Immunol (2013) 0.83

Strategies and challenges in eliciting immunity to melanoma. Immunol Rev (2008) 0.82

Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance. Med Microbiol Immunol (2012) 0.82

Stimulation of CD8+ T cells following diphtheria toxin-mediated antigen delivery into dendritic cells. Infect Immun (2006) 0.82

A protective role of murine langerin⁺ cells in immune responses to cutaneous vaccination with microneedle patches. Sci Rep (2014) 0.82

Identification of three distinct subsets of migrating dendritic cells from oral mucosa within the regional lymph nodes. Immunology (2009) 0.81

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function. J Leukoc Biol (2011) 0.81

Induction of T cell immunity by cutaneous genetic immunization with recombinant lentivector. Immunol Res (2006) 0.80

The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism. Int J Tryptophan Res (2015) 0.80

Role of immune-regulatory cells in skin pathology. J Leukoc Biol (2010) 0.80

Articles cited by this

Dendritic cells and the control of immunity. Nature (1998) 56.54

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med (1985) 11.14

Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19

Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (2003) 5.52

Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science (2003) 5.00

Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol (2001) 4.82

Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med (2003) 3.86

Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol (1993) 3.73

The dendritic cell populations of mouse lymph nodes. J Immunol (2001) 3.57

Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood (2002) 3.19

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today (1998) 3.12

Shutdown of class switch recombination by deletion of a switch region control element. Science (1993) 2.99

Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci U S A (1992) 2.77

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin. J Immunol (1993) 2.17

Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood (1999) 2.09

Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J Invest Dermatol (2003) 1.93

Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int Immunol (2001) 1.68

Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J Immunol (2000) 1.68

Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells. J Infect Dis (1982) 1.67

Langerhans cells - dendritic cells of the epidermis. APMIS (2003) 1.64

CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis. Eur J Immunol (2004) 1.61

Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J Immunol (2002) 1.53

Identification and expression of mouse Langerin (CD207) in dendritic cells. Int Immunol (2002) 1.44

Ontogeny of Langerin/CD207 expression in the epidermis of mice. J Invest Dermatol (2004) 1.41

Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha. J Immunol (1992) 1.39

Epidermal Langerhans cell migration and sensitisation to chemical allergens. APMIS (2003) 1.25

Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J Immunol (1995) 1.24

Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res (2003) 1.16

A model system using tape stripping for characterization of Langerhans cell-precursors in vivo. J Invest Dermatol (2004) 1.13

Immunology. Giving credit where credit is due. Science (2003) 0.89

Articles by these authors

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32

HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 6.56

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods (2005) 5.59

Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med (2008) 5.42

Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell (2010) 5.28

In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med (2004) 5.07

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science (2014) 4.91

SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90

The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med (2002) 4.78

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity (2007) 4.70

DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J Exp Med (2003) 4.69

Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med (2003) 4.44

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med (2003) 4.41

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med (2004) 4.35

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med (2005) 4.34

Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med (2002) 4.32

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med (2008) 3.97

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med (2009) 3.68

Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol (2002) 3.61

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59

Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med (2002) 3.35

Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity (2012) 3.18

Distinct differentiation potential of blood monocyte subsets in the lung. J Immunol (2007) 3.16

The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol (2003) 3.06

Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol (2006) 3.06

alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity. Cancer Res (2004) 3.00

Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. J Exp Med (2005) 2.90

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86

A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 2.82

Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol (2005) 2.70

CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.66

A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem (2002) 2.61

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol (2003) 2.59

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A (2008) 2.57

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages. J Immunol (2007) 2.55

Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med (2006) 2.53

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood (2008) 2.52

Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci U S A (2005) 2.47

Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. J Clin Invest (2007) 2.46

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 2.43

Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol (2004) 2.40

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40

HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci U S A (2004) 2.38

A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell (2006) 2.37

Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci (2003) 2.36

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients. Blood (2006) 2.36

Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity (2005) 2.35

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol (2008) 2.33

Epigenetic ontogeny of the Igk locus during B cell development. Nat Immunol (2004) 2.25

Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med (2003) 2.23

Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc Natl Acad Sci U S A (2005) 2.22

Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J Exp Med (2003) 2.20

Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. J Immunol (2005) 2.17

Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol (2002) 2.16

Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med (2008) 2.15

Flt3 signaling-dependent dendritic cells protect against atherosclerosis. Immunity (2011) 2.14

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12

Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity. J Exp Med (2005) 2.10

Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 2.10

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J Exp Med (2011) 2.09

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity (2013) 2.08

Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. J Exp Med (2004) 2.08

CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity (2006) 2.06

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol (2007) 2.05

DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A (2007) 2.04

Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity (2008) 2.04

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci (2013) 2.03

The interaction of HIV with dendritic cells: outcomes and pathways. Trends Immunol (2007) 2.03

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02

DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol (2007) 2.02

Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med (2013) 1.99

A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity (2013) 1.94

CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med (2009) 1.93

Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. PLoS Pathog (2009) 1.92

Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med (2008) 1.92

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc Natl Acad Sci U S A (2003) 1.91

Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci U S A (2006) 1.91