Published in Neurobiol Dis on November 01, 2005
Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J Neurosci (2009) 1.20
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci (2014) 1.11
Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem (2011) 1.09
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem (2010) 1.03
APP physiological and pathophysiological functions: insights from animal models. Cell Res (2011) 1.03
Presenilin transgenic mice as models of Alzheimer's disease. Brain Struct Funct (2009) 0.98
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow. Mol Neurodegener (2014) 0.91
Changes in voiding behavior in a mouse model of Alzheimer's disease. Front Aging Neurosci (2015) 0.85
Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging (2012) 0.85
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. PLoS One (2013) 0.80
Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci (2015) 0.79
The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease. Acta Neuropathol Commun (2013) 0.79
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem (2005) 3.06
Structural characterization of a soluble amyloid beta-peptide oligomer. Biochemistry (2009) 2.31
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem (2007) 1.71
Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci (2008) 1.54
Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β. J Alzheimers Dis (2012) 1.39
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J (2009) 1.36
Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease. J Neurosci (2011) 1.36
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? ChemMedChem (2008) 1.32
Novel γ-secretase enzyme modulators directly target presenilin protein. J Biol Chem (2011) 1.24
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem (2007) 1.20
Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. J Neurosci (2010) 1.20
Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid. Rev Neurosci (2009) 1.15
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem (2008) 1.13
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry (2009) 1.11
The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett (2002) 1.06
Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem (2011) 1.05
Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET. J Nucl Med (2013) 0.98
Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PLoS One (2012) 0.97
Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease. Neurobiol Aging (2010) 0.96
Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor. Bioorg Med Chem Lett (2007) 0.92
IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination. J Neurochem (2008) 0.92
The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats. Eur J Neurosci (2004) 0.91
Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. J Pharmacol Exp Ther (2010) 0.89
Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET. Neuroimage (2013) 0.89
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. J Med Chem (2006) 0.88
Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase. J Neurochem (2007) 0.85
Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients. Parkinsonism Relat Disord (2003) 0.84
Aminothiazoles as γ-secretase modulators. Bioorg Med Chem Lett (2011) 0.84
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. J Med Chem (2010) 0.82
NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold. Bioorg Med Chem (2011) 0.80
Excessive weight gain in rats over extended kindling of the basolateral amygdala. Neuroreport (2003) 0.80
Age-related changes in parvalbumin-positive interneurons in the striatum, but not in the sensorimotor cortex in dystonic brains of the dt(sz) mutant hamster. Brain Res (2007) 0.79
Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism. Neurodegener Dis (2007) 0.79
NO-cGMP signaling molecules in the rat epithelial rests of Malassez. Eur J Oral Sci (2004) 0.78
Effects of Abeta1-42 fibrils and of the tetrapeptide Pr-IIGL on the phosphorylation state of the tau-protein and on the alpha7 nicotinic acetylcholine receptor in vitro. Eur J Neurosci (2005) 0.78
An ELISA-based method for the quantification of incorporated BrdU as a measure of cell proliferation in vivo. J Neurosci Methods (2006) 0.78
Amygdala-kindling does not induce a persistent loss of GABA neurons in the substantia nigra pars reticulata of rats. Brain Res (2004) 0.78
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. ACS Chem Biol (2012) 0.77
Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons. Brain (2013) 0.77
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase. Bioorg Med Chem Lett (2006) 0.76
NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring. Bioorg Med Chem Lett (2009) 0.75
Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta. Bioorg Med Chem Lett (2010) 0.75
Localization of the neuropeptide galanin in nerve fibers and epithelial keratinocytes of the rat molar gingiva. Eur J Oral Sci (2003) 0.75
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3. Bioorg Med Chem Lett (2012) 0.75
Localization of the NO-cGMP signaling pathway molecules, NOS III-phosphorylation sites, ERK1/2, and Akt/PKB in osteoclasts. J Periodontol (2004) 0.75
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res (2012) 0.75