Published in Proc Natl Acad Sci U S A on May 31, 2005
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The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol (2010) 2.33
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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy (2014) 1.85
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe (2008) 1.85
Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A (2012) 1.83
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging (Albany NY) (2012) 1.79
p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A (2010) 1.77
Autophagy in cellular growth control. FEBS Lett (2010) 1.74
Tumor suppression by autophagy through the management of metabolic stress. Autophagy (2008) 1.71
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry. Cell Stem Cell (2015) 1.67
Stressin' Sestrins take an aging fight. EMBO Mol Med (2010) 1.65
Autophagy: for better or for worse. Cell Res (2011) 1.65
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet (2008) 1.63
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
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Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy (2010) 1.58
Signaling pathways in mitochondrial dysfunction and aging. Mech Ageing Dev (2010) 1.54
Regulation of protein synthesis by ionizing radiation. Mol Cell Biol (2009) 1.52
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Proc Natl Acad Sci U S A (2009) 1.50
p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50
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Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol (2011) 1.48
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med (2009) 1.43
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Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. J Am Coll Surg (2010) 1.41
The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol (2009) 1.40
mTOR signaling for biological control and cancer. J Cell Physiol (2013) 1.40
Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene (2010) 1.40
Rapalogs in cancer prevention: anti-aging or anticancer? Cancer Biol Ther (2012) 1.40
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J Biol Chem (2008) 1.35
DNA damage and autophagy. Mutat Res (2011) 1.34
A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol (2008) 1.34
Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis. Int J Radiat Oncol Biol Phys (2009) 1.34
Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program. Mol Cancer Ther (2010) 1.34
Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol (2010) 1.34
Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death Differ (2011) 1.33
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Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy (2011) 1.30
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. Antioxid Redox Signal (2011) 1.29
Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell (2007) 1.28
Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense. Semin Cancer Biol (2008) 1.27
Autophagy and tumorigenesis. Semin Immunopathol (2010) 1.26
P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy. Oncotarget (2013) 1.26
Autophagy and ethanol-induced liver injury. World J Gastroenterol (2009) 1.26
Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes Dev (2009) 1.26
The Role of p53 in Metabolic Regulation. Genes Cancer (2011) 1.25
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The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol (2012) 1.24
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal (2012) 1.23
The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron (2010) 1.22
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Clin Cancer Res (2008) 1.21
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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Rapid and accurate calculation of protein 1H, 13C and 15N chemical shifts. J Biomol NMR (2003) 4.39
p53 regulates maternal reproduction through LIF. Nature (2007) 4.12
SuperPose: a simple server for sophisticated structural superposition. Nucleic Acids Res (2004) 4.09
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov (2008) 4.03
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The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
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Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A (2009) 3.41
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res (2006) 3.26
The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res (2006) 3.22
The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains. Autophagy (2007) 3.14
MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets (2005) 3.04
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci U S A (2008) 2.90
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
Allele-specific p53 mutant reactivation. Cancer Cell (2012) 2.51
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC Syst Biol (2010) 2.49
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. Cancer Res (2007) 2.48
Molecular classification of prostate cancer using curated expression signatures. Proc Natl Acad Sci U S A (2011) 2.46
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A (2007) 2.36
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol (2010) 2.33
Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS Pathog (2010) 2.32
A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32
Autophagy regulates ageing in C. elegans. Autophagy (2007) 2.22
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. J Virol (2006) 2.06
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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS Pathog (2008) 1.96
Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92
Tissue-specific codon usage and the expression of human genes. Proc Natl Acad Sci U S A (2004) 1.91
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
Identification of bacteria using tandem mass spectrometry combined with a proteome database and statistical scoring. Anal Chem (2004) 1.89
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res (2006) 1.89
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
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p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism. FASEB J (2010) 1.77
Autophagy and the degradation of mitochondria. Mitochondrion (2010) 1.75
Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy (2009) 1.72
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A (2003) 1.69
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
The tumor suppressor p53: cancer and aging. Cell Cycle (2008) 1.66
Accurate prediction of protein torsion angles using chemical shifts and sequence homology. Magn Reson Chem (2006) 1.66
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell (2004) 1.65
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev (2002) 1.57
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. Proc Natl Acad Sci U S A (2009) 1.54
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell (2010) 1.49
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J Biol Chem (2005) 1.47
Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. J Am Soc Nephrol (2009) 1.45
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The regulation of the endosomal compartment by p53 the tumor suppressor gene. FEBS J (2009) 1.39
Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old. J Virol (2010) 1.38
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LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36
A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice. J Lipid Res (2010) 1.36
MDM2 SNP309 accelerates colorectal tumour formation in women. J Med Genet (2006) 1.35
Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. J Biol Chem (2003) 1.29
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Automatic categorization of diverse experimental information in the bioscience literature. BMC Bioinformatics (2012) 1.27
miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1. Biochem Biophys Res Commun (2011) 1.25
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets. Nucleic Acids Res (2007) 1.22
Non-random reassortment in human influenza A viruses. Influenza Other Respir Viruses (2008) 1.20
p53: a new player in reproduction. Cell Cycle (2008) 1.20
Anomalies in the influenza virus genome database: new biology or laboratory errors? J Virol (2008) 1.19
Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proc Natl Acad Sci U S A (2005) 1.18
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res (2012) 1.17
A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities. J Bacteriol (2005) 1.14
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival. Cancer Res (2009) 1.13
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer (2010) 1.12
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system. PLoS One (2009) 1.12
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A (2012) 1.11
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers. PLoS One (2012) 1.10
Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing. BMC Plant Biol (2012) 1.09
Crp-dependent cytochrome bd oxidase confers nitrite resistance to Shewanella oneidensis. Environ Microbiol (2013) 1.09
MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway. J Pathol (2014) 1.08
Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08
Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci U S A (2009) 1.08
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe (2013) 1.06
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer (2012) 1.06
Stem cell biology meets p53. Nat Biotechnol (2009) 1.04